“highly significant”

A clear change in the substitution pattern was observed in the ENVV1/ENVV2 alignment, and a subsequent gene-conversion test [ 29 ] yielded highly significant results (P < 0.00066, Table 1 ).

In fact, permutation test analyses (100,000 iterations) detected highly significant values for П (P = 0.00066) and π (P = 0.00063) in Intermediate Area populations compared to those from the Magellanic Province.

However, after six months (T2), a highly significant change was noted compared to the measurement taken three months prior with a reduction in overjet ( p = 0.00066).

A comparison of ticks feeding on wild-type versus engineered mice revealed a highly significant difference in infection status ( p = 6.9E−4)(Fig. 3B ). 80% of engineered mice previously challenged with a large number of infected ticks were completely free of infection.

We obtained a relatively small but significant effect of exposed ( R 2 = 0.005, P = 0.030), a stronger effect of enveloped ( R 2 = 0.032, P < 10 -5 ), and a highly significant interaction between these factors ( R 2 = 0.012, P = 6.9 × 10 − 4 ).

If the number of pregnancies are grouped so that three or more pregnancies are placed in the same category, as in most previous studies (Byers et al., 1982; McMichael & Potter, 1984; Potter & McMichael, 1983; Weiss et al., 1981), there is a highly significant protective trend with increasing numbers of pregnancies (P = 0.0007) (Table II).

Under R → RB → R and the reverse sequence, RB → R → RB, fitting the g s data to a linear mixed-effects model ( Tables S8 and S9 ) showed a highly significant effect of light (R-RB-R, p=0.0007;RB-R-RB, p=0.0060), but the main effect of species (R-RB-R, p=0.3455; RB-R-RB, p=0.8859) and its interaction with light (R-RB-R, p=0.2055; RB-R-RB, p=0.7486) were not significantly different.

Osteoblasts cultivated on TiN coated material revealed a highly significant increased expression of ITG-β1 (2.22 ± 0.42; *** p = 0.0007) and ITG-α1 (2.36 ± 0.28; *** p = 4.37 × 10 −5 ).

However, concurrent manifestation of all three classic signs of loiasis pruritus, Calabar swelling, and eyeworm, was a highly significant predictor of infection ( p = 0.0007).

A similar pattern was observed for SMS, SMOX and SRM, all of which were associated with poor prognosis in LIHC, while the others did not show any highly significant difference (SMS; HR 1.9, p = 7e−04; SMOX: HR 1.7, p = 0.003; SRM: HR 1.7, p = 0.03).

For the multi-rate stimulus ([1234]; compare filled orange triangles), all participants, with the exception of MED06 and possibly MED05, assigned higher pitch ranks to the LD than to the SD version, and this difference was highly significant at the group level ( t (7) = 5.79, p = 0.0007**, d = 2.0).

Interestingly, IL-27 levels showed a moderate (R = 0.3781) albeit highly significant ( p = 0.0007) correlation with sPD-L1 levels, suggestive of a potential role for IL-27 in PD-L1 upregulation in vivo ( Figure 3 B).

Postoperative visual analog scale score was 4.8 ± 1.12 in Group BN, and in Group BF, it was 3.86 ± 1.04 which was statistically highly significant ( P = 0.0007).

Normo-weighted subjects showed a highly significant decrease in periodontal inflammation (PISA index) (986.99 mm 2 ± 591.47 vs. 477.28 mm 2 ± 542.55, p = 0.0007) after periodontal treatment, shifting from a severe state of periodontitis to a mild state of periodontitis ( Figure 3 ).

Although this was still a highly significant reduction of melanoma cell numbers ( p = 0.0007), the surviving cell fraction increased again after irradiation.

Further the haplotype C/C/C/C/T/1 can be considered as an extended protective haplotype as it was found in 31.9% in the controls when compared to 11.6% in ESRD with highly significant P value ( P = 0.0007) [ Table 3 ].

Friedman ANOVA showed highly significant changes in cortical mRNA expression of all targeted genes—Il1b ( p = 0.0007), TNF ( p = 0.00002), Il6 ( p = 0.0015), TGFb ( p = 0.0098), Panx1 ( p = 0.0001), and CGRP ( p = 0.0039)—at three hours after the injury.

The caffeine–MoCA association remained highly significant in the E3/E3 homozygous subgroup ( n = 45, p = 0.0007), demonstrating robustness to genetic stratification and ruling out confounding by APOE -related differences in caffeine metabolism or cognition.

Functional group richness had a highly significant negative relationships with latitude (P = 0.0007, R 2 = 0.7101, F = 25.49, df = 9).

The differences were highly significant at both 12 (P =0.0007) and 24 (P = 0.0115) weeks between the two groups.

In addition, worse liver activity grade (A2-A3) had a very highly significant association with non-responder HCV patients compared to those with better liver activity grade (A1) (95% confidence: 2.242 - 20.974, P = 0.0007).

Also brain tumors and/or sarcomas were overrepresented in the carrier families (28.6%, Table 2 ); the difference being highly significant when compared to the incidence of these cancers in the analyzed cohorts (5.1%, P = 0.0007, OR 7.4 95% CI 2.7–19.9).

There was a highly significant correlation between HPyV6 DNA PCR and HPyV6 FISH results ( p = 0.0007; Fisher’s exact test).

Post hoc t tests (with Tukey correction for multiple comparisons) revealed that TTX increases in activity were highly significant in both WT (p=0.0007) and TKO (p<0.0001) slices and that TTX produced a significantly stronger increase in the TKO (p<0.0001), while the baseline activity of cells from slices derived from the TKO and WT do not differ significantly (p=0.92).

5 , compared to the vehicle-control group, AAV9-CRISPR/Cas9-treated mice showed a highly significant increase in the number of spontaneous alterations ( p = 0.0007).