“highly significant”

Another clone (5B3, from pool F, Mm8 Chr16: 91155139–91157882), containing an insert located 57 kb downstream of 5A5, similarly induced expression in the trigeminal ganglion ( Figure 2 ), although in this case the penetrance of the phenotype was lower (41%, n = 22), albeit highly significant (p = 8×10 −4 ).

Weaker correlations, but highly significant, were found between vertical jumps in adulthood and gross motor skills in childhood ( ρ ( n =168) = 0.26, p = 0.0008), body perception ( ρ ( n =166) = 0.29, p = 0.0002), and social skills in childhood ( ρ ( n =168) = 0.25, p = 0.0009).

The 6 months results of HRQoL, sleepiness, depression, cognition, disability and walking speed were all highly significant (p<0.0008–0.0001) and consistent with the results at 12 months (data not shown).

The distribution of hypermethylation and hypomethylation loci among comparison pairs was highly significant (χ 2 (2-df) = 14.17, P = 0.0008).

The coefficient for PC1 is positive β ^ PC1 = 1.00 and highly significant ( p = .0008).

These differences were found to be highly significant ( p = 0.0008) with a Fisher’s Exact test.

A linear test-for-trend based on the log-rank test (Tarone, 1975) yielded a highly significant P value (x2= 11.2, P=0.0008).

This overlap is highly significant (OR = 2.0, p = 0.0008, Fisher’s exact test).

Mantel tests [ 27 ] of the significance of correlations between matrices of (i) pairwise population differentiation at the LWS locus, (ii) pairwise difference in water transparency, and (iii) pairwise geographical distance, revealed a highly significant positive correlation between LWS divergence and transparency (cross matrix correlation 0.80, p = 0.0008), but only a weak correlation between LWS divergence and geographical distance (0.55, p = 0.04), and an even weaker correlation between transparency and geographical distance (0.42, p = 0.08).

The increased association of the Firre locus with the nucleolus surface in female versus male cells was highly significant ( P = 0.0008 by one-sample t-test).

While healthy participants showed a highly significant intervention effect on change in global cognition, t (86) = 3.48, p = 0.0008, Cohen’s d = 0.54, participants with MCI, t (108) = 1.45, p = 0.15, Cohen’s d = 0.19, and dementia, t (25) = 0.14, p = 0.89, Cohen’s d = 0.04, did not show a significant improvement.

After 5 weeks of peptide stimulation a highly significant ( P = 0·0008) Bax-specific response was observed from patient R6A8R89 (Fig. 1a ).

Since the point values of the tests each deviate in a highly significant manner from normal distributions (Shapiro-Wilk tests: all p <0.0008), the data were subjected to a multivariate Box-Cox transformation [ 1 ].

A pooled analysis of all data showed a highly significant effect of colony environment on aggression (analysis of z-scores: whole model: F 18,982 = 2.43, P < 0.0008, foster colony aggression level: F 1 = 17.3, P < 0.0001, worker genotype: F 17 = 1.6, P < 0.069; the interaction term was non-significant and so excluded).

The differences between CASK -mutant and control neurite arbors were highly significant statistically, with magnitudes suggestive of biological significance: total neurite length (-35%; p = 0.0008), territory area (-48%; p = 0.0004), higher-order branch number (-30%; p = 0.0023) and branch density (+ 39%; p = 0.0006).

The protection was highly significant, with p = 0.0008 for both treatment groups compared with the controls.

Arthralgia was found to have a highly significant association (p < 0.0008) with stress scores.

We chose asthma nonetheless for its status as the most prevalent atopy in SIgAD patients (19.1%) [ 18 ], its highly significant GPS test statistic (p = 0.0008), and our access to a highly-powered asthma GWAS for use as an auxiliary data set ( Supplementary Table 1 ).

The combination of buparlisib and RT in UT-SCC-15 showed the greatest growth delay and the combination was highly significant (p = 0008) compared to RT alone.

We identified three highly significant module-trait correlations (|AverageCorr | > 0.5, p -value < 8e-4), with each linked to DLB and Control, and composed of CpGs ranging from 39 to 157 (Supplementary Data 2 ).

Highly significant differences were observed for bone marrow, mature bone, immature bone, and residual graft material, with all adjusted p-values ≤ 0.0008.

2A to D ), and the highly significant ( P = 0.0008) reduction in bacterial resistance to some antibiotics from IIS to WWE ( Fig. 2B ), reinforces the need for adequate water treatment for all and preventing natural environmental surface waters having similar community profiles to untreated wastewater.

A highly significant difference was observed between the maximum stress value for the RC scaffolds versus XYP scaffolds when the deposition time was 45 min ( p = 0.0008, F = 81.55, and critical F = 7.71); however, no significant difference was observed for the elongation at break ( p = 0.24, F = 1.89, and critical F = 7.71).

For the SPHLJ positive SARS-CoV-2 RT–PCR tests, the period from June 2020 to May 2021 showed a highly significant Granger causality association ( p = 0.0008), indicating that Ct values effectively predicted changes in this metric.

In the Kaplan-Meier curve of the external dataset, we observed a highly significant association between the high- and low-risk groups and survival time ( p -value = 0.00082), providing strong evidence for the suitability of our model in prognostic prediction. 3.3 Multivariate cox regression analysis and TF-target gene network construction To explore other additional factors affecting CRC, a total of 317 samples, including phenotypic data, were subjected to Cox single-factor regression analysis for age, sex, pathological stage, lymphatic invasion, and risk score.