“highly significant”

Educational Resources also presented a highly significant effect ( p = 2.8 × 10 −22 ), with a moderate degree of association between categories ( φ c = 0.439), and the same was true for ESAR Facets ( p = 5.15 × 10 −16 ; φ c = 0.366).

Restricting to individuals with Asian or European ancestry, we confirmed a highly significant increase in EGFR mutation rate in tumors from individuals with Asian ancestry (18% in samples of European ancestry; 57% in samples of Asian ancestry; p = 3 × 10 −22 by logistic regression).

Firstly, there is a highly significant correlation between the measured binding data and the predicted homophilic binding strength (Pearson’s r = 0.86, p ≅ 0 and Spearman’s r = 0.81, p = 3.03e-22, Additional file 2 : Table S3).

Analyzing the same brain regions from another group of mice using our custom array platform revealed another highly significant CpG to be hypomethylated in the Q175 group (probe cg12389415 on the custom array, mouse chr5:34795955) also within the Htt locus (meta-analysis p = 3.2 × 10 −22 ; Supplementary Fig. 25 ).

This highly significant result ( P < 4 × 10 −22 ) and the differentially expressed pattern of fshrx ( Figure 3 ) are compatible with the observation of Dor et al.

The analysis for DtxR cells showed significant downregulation of BChE with a Log 2 FC of −12.3, a highly significant p-value (p = 4.35 × 10 −22 ), and a false discovery rate (FDR) of (8.81 × 10 −21 ).

We detected a highly significant difference (heteroscedastic t -test, t 38 = 20.4, P = 4.5 × 10 −22 ) in estimated copy number between 119S/S (mean ± 95%CI = 4.75 ± 0.32) and 119G/G (mean = 1.12 ± 0.09) individuals (Fig. 5 A).

Combining p -values across all datasets again yielded highly significant differences ( p = 4.7 × 10 −22 for Fisher's combined probability).

This is a highly significant enrichment (p = 4.85×10 −22 , one-sided hypergeometric test) compared to 12.9% of background AS genes showing developmental regulation.

There was a highly significant difference between geographical locations in both the allele frequency ( X 2 = 127.7, DF = 11, P-value = 4.97x10 -22 ) and frequency of homozygosity ( X 2 = 142.3, DF = 22, P-value = 1.33x10 -19 ).

Relative to the average in syntenic regions, SNPs within ASCs showed a highly significant shift toward lower frequencies ( P = 5 × 10 −22 ) ( Fig. 1C ; Supplemental Note 2), indicating that mutations in ASCs are more deleterious than mutations at random genomic locations.

2014 ) knockout embryos and found a highly significant overlap ( P = 5.9156 × 10 −22 , hypergeometric test) between the genes up-regulated in Ehmt2 −/− and Dnmt3b −/− at E8.5 (Supplemental Fig.

Interestingly however, when compared with the HER2+ subgroup only the Georgia set showed a highly significant increase ( p = 6.00 ×10 -22 ) in MMP7 .

The Figure shows a highly significant correlation between duplicates (R = 0.83, p = 6 × 10 (−22) , Pearson correlation) with a slope of 0.86.

Consistent with this hypothesis, there was a moderately strong, but highly significant, correlation (Spearman rank correlation = 0.47, p < 7.2 x 10 −22 , S5 Fig ) between the ConSurf score for a residue and the median yeast assay score for substitutions at that site, with more conserved residues displaying lower median growth.

The median follow-up for T-DXd was 16.2 months; the median PFS was 6.8 months for the T-DM1 groups, while the median PFS had not been reached for the T-DXd group, with a highly significant difference (HR of 0.28, 0.22-0.37, P = 7.8 × 10 -22 ).

As expected, the coefficient corresponding to stimulus number was negative (i.e., higher performance was observed for displays with fewer stimuli), and highly significant for all monkeys (regression analysis, subject EL: p = 7.9 × 10 −22 , subject NI: p = 0.0197; subject DA: p = 0.0011, subject CA: p = 1.98 × 10 −9 ).

In terms of correlation analysis, the Pearson correlation coefficient was 0.959, demonstrating a very strong positive correlation between ADRRPs and phoropter measurements ( p = 8.13 × 10 − 22 , highly significant), while the Spearman correlation coefficient was 0.878, also indicating a strong positive correlation ( p = 2.03 × 10 − 1 3 , highly significant).

2 inset), a highly significant difference (p = 8.62×10 −22 , Fisher's exact test) suggesting that introducing the epigenetic mechanism enabled networks to evolve a strongly increased capacity for adding new input/output states.

This pair is highly significant based on all 5 DPA methods as well as the OffSides database (rr= 2.75000000015865, p value < 8.67518006759968e-22).

Results confirmed that the use of ACE-I was a significant protective factor for COVID-19 in-hospital mortality (Hazard Ratio: 0.61; 95% CI: 0.38–0.98; p = 0.04) with a highly significant model ( p = 9.99E-22; n = 444) ( Table 3 ). 4.

371 of these were within a central cluster representing highly significant overlap (p<1e-21; 1.55-fold enrichment).

However, in this present study, when the tRNA genes were considered as a concatenated sequence, the lack of transposon insertions was highly significant ( P -value = 10 −21 ), thus supporting their essentiality.

Results With all possible fMRI contrast parameters, the three-factor models were highly significant ( p < 1.0 x 10 -21 ).

The rate of dS and dN substitutions between BMPR1BBY and BMPR1BB is 0.12 and 0.07, respectively, yielding a dN/dS ratio of 0.58, a dramatic and highly significant ( P < 10 −21 ) increase compared with dN/dS ratios of 0.01 to 0.02 in other branches of the tree ( Fig. 2 B and SI Appendix , Fig.