“highly significant”

7C ), of which 558, or 90.6%, a highly significant proportion ( P = 6 × 10 −23 , hypergeometric test), were associated with OLIG2 binding sites within one or more of the CREs defined in this study, suggesting that OLIG2 acts as a transcriptional activator for some of its functions in NS cells.

S3), as well as a highly significant negative genetic correlation between c-intensity and age at menarche (rg = − 0.52, P = 6.72 × 10 −23 ), indicating that genetic determinants of later pubertal onset also favor a slower tempo of growth.

While increasing the pull speed slightly reduces the modulus of the baseline APA (estimate −223.7, p = 0.0472), the massive and highly significant interaction term (estimate 4015, p = 7.04 × 10 −23 ) reveals that combining high draw speeds with high LCP concentrations dramatically increases the overall stiffness of the extrudate.

When comparing these two gene lists we observed extensive overlap (N = 263) that was calculated to be highly significant (p < 7.130e-23)( Supplementary Table S1 ).

Among them, we focused on SNHG15 due to its highly significant upregulation in tumors ( p value =7.5e-23) and also the highest correlation with poor survival of patients ( p value = 4e-5) (Fig. 1 b).

Survival analysis confirmed the highly significant impact of IL-6 (P = 8.56e−23) on the survival of COVID-19 patients and also identified a nominally significant effect of IL-2R on survival (P = 0.0003, Figure S1 , Table S1 ).

The genetic principal component PC4 was highly significant log(HR) = 3.4 × 10 −2 , p = 9.2 × 10 −23 .

Moreover, as anticipated, differences between the mean pH values of the n = 6 participants included in this phase of the study were indeed very highly significant ( p = 9.42 × 10 −23 ), with ranges in their mean values being 5.49–6.37.

This difference was highly significant (Wilcoxon rank-sum test, p = 9.46 × 10^-23).

Cuzick’s test for linear trend showed that these median LRS values were linearly related to the T2D status and highly significant ( p < 1.0x10 −22 ).

This difference is highly significant ( t -test, p -value < 10 −22 ) and clearly demonstrates the improvement of the pop-out recombination step or the counterselection step with 6-MP. 3.5.

Strikingly, we found that 41.9% (1328 out of 3173 sites) were edited at significantly higher levels in the brain than in non-brain tissues ( P < 0.05, Wilcoxon test), which represented a highly significant enrichment for brain-specific editing compared to various negative controls (see ‘Materials and Methods’ section) ( P < 1 × 10 −22 , Fisher’s test) (Figure 5H and Supplementary File S1 ).

The enrichment for suspected translationally repressed transcripts among the dysregulated proteins of the P clag - cdpk1-gfp was highly significant (p < 10 −22 ).

Statistical validation of these compositional shifts using chi-squared tests revealed highly significant alterations across all comparisons ( p < 10–22), with effect sizes ranging from moderate to very strong (Cramér’s V = 0.29–0.56).

Both effects remained highly significant after spike rate equalization ( Supplementary Fig. 3b,d online; P < 10 −22 , Wilcoxon signed-rank test, n = 166 neurons from 19 experiments).

In the final combined analysis, there was highly significant evidence for association with MS in this region ( p = 1.1e− 22).

Friedman tests consistently ranked FW-CAGIN first (mean rank = 1.0 across all features and datasets; Appendix B , Table B6), with highly significant differences (χ 2 = 73.73–105.21, p < 1.18e−22; Appendix B , Tabke B4).

First, an analysis of expression levels using RNA-seq data from the Maize Gene Atlas [30] reveals a small (∼20%) but highly significant depletion of low-expressed genes (p = 1.30×10 −22 by Mann-Whitney test and ≈0 by Kolmogorov-Smirnov test) ( Fig. 6 ).

Correlation analysis using TCGA database (N = 1,082) across all breast cancer subtypes revealed a highly significant association between ErbB2 and BLVRB expression (ρ = 0.291, p = 1.30 × 10 −22 , Fig. 6 L).

The significant association between assessment patterns with readiness to feed was demonstrated by a highly significant χ 2 test result, which was 95.68 and p < 1.35 e − 22 for 2 clusters (ready to feed vs. not ready).

To validate our networks, we determined whether our NBIA-containing modules are composed of the same genes as those in publicly available caudate nucleus networks ( Oldham et al., 2008 ) and identified a highly significant overlap between these two basal ganglia networks (e.g. our brown module vs their M16C module: p = 1.38 × 10 − 22 ; our green module vs their M9C module: p = 2.69 × 10 − 166 ).

This revealed a highly significant relationship between the level of methylation of the CASP1 promoter and CASP1 mRNA expression in ALL cells (p = 1.4 × 10 −22 ; Fig. 1F , Supplementary Fig. 2 panels A–C ).

This overlap is still highly significant, although less striking than in SAT (p = 1.6 × 10 -22 ; Fisher's exact test assuming that 20,000 different genes were tested).

The DML overlap between the two cohorts was highly significant ( p = 1.71 × 10 −22 , 8.17 × 10 −33 and 3.13 × 10 −44 in B cell, memory T cell and Naïve T cells, respectively, by hypergeometric tests).

Among the IFN -inducible genes, HLA-DPA1 , PSMB8 , PSMB9 , TAP1 and TAP2 were proximal to rs3129750, a highly significant genetic variant associated with TB ( P = 2.51e-22), providing genetic support for these genes as potential host targets.