“highly significant”

The difference between these two slopes was highly significant ( t (72) = −11.5; p = 6.1×10 −18 ).

Approximately 40% of downregulated genes in Platr22 4*PA KI mESCs are also downregulated in ZFP281 KO cells, and the overlap is highly significant ( P = 6.18E−18; Figure 4B ).

Whereas, RNA M of newly reported Chinese isolate YNKM-2 had one highly significant recombination event ( P -value = 6.586 × 10 − 18 ) spanning from 3111 to 3811 bp (without gaps), detected by seven algorithms i.e., RDP, GeneConv, Bootscan, MaxChi, CHIMAERA, SisScan, and 3SEQ.

16p13.3 has a cis -effect on MLST8 and possibly PGP Our cis -expression QTL study shows that rs30986 has a highly significant positive correlation with the expression levels of MLST8 in at least 9 brain regions (meta-analysis P =6.9 × 10 −18 , Fig. 2b , Supplementary Fig. 7b ) including the cerebellum (meta-analysis P =4.9 × 10 −5 , see Fig. 2b and Supplementary Table 4 ), temporal cortex, hippocampus and substantia nigra.

81 compounds were shared, and this finding is highly significant ( p = 7 × 10 − 18 , two-sided Fisher’s Exact Test) (Fig. 5 c).

However, by zone 3 the PC of chromosome III was paired in 90% of wild-type nuclei, but only in 48% of s pd-3(me85) mutant nuclei ( Figure 3B ), and this difference is highly significant ( p = 7E-18).

Notably, there was highly significant overlap ( p <7.2 × 10^−18; Fisher’s exact test) between general essential genes identified by our study and those previously reported [ 15 ] (Figure S1c in Additional file 2 ).

The comparison ATA + versus ACA + and ARA + subgroups was highly significant ( P = 9.06 × 10 −18 , P = 2.88 × 10 −9 ), emphasizing C4A impact in ATA + patients (Figure 1 ).

Marker-trait association analysis of RphC in the CI 9214/Stirling DH population using 4,500 DArT-seq markers identified a highly significant (−log 10 Pvalue > 17) single peak on the long arm of chromosome 5H (5HL).

We found highly significant evidence of positive selection acting on Avian GSTA2 ( p < 10 −17 ; M8 PAML, Supplementary Table 9 ) and identified with high statistical confidence (posterior probabilities >0.99) several GSTA2 sites targeted by this acceleration in evolutionary rates ( d N / d S = 3.50; Fig. 4a ).

Out of the 25 highly significant oil-associated DNA variants (23 SNPs and 2 InDels with p ≤ 1 × 10 −17 ), a 321-bp InDel showed the most significant association ( p = 6.17 × 10 −24 ) (Fig. 1a ).

Regression coefficients were highly significant for both attraction coefficient (0.36, t = 12.7, P < 1 × 10 −17 ) and AR (0.18, t = 6.5, P < 1 × 10 −9 ).

Spearman’s correlation analysis (Supplementary Table 5 ) revealed moderate (−0.476 and −0.610) but very highly significant ( p < 1 × 10 −17 ) associations between the level of locomotor activity and two conditions (18 °C and DD, respectively).

Because the persistence-length data did not satisfy normality (Shapiro–Wilk p = 0.002), differences between force fields were assessed using a Wilcoxon rank-sum test, which showed a highly significant effect of force field ( p -value ≈ 10 −17 ), whereas no significant differences were detected across chain lengths, suggesting that the persistence length is largely independent of chain length over the range considered.

Given this probability, the fact that we retrieved only 9 (24%) is highly significant (P < 10 −17 from binomial test; P < 1/3001 from simulation test accounting for uncertainty in the retrieval probability, text in S1 File ).

The whole model was highly significant ( p < 10 −17 ; R 2 = 0.27).

Blood glucose concentrations at each time were subjected to RMANOVA examining for the main effects of time and treatment and the time × treatment interaction; after demonstrating a highly significant time × treatment interaction ( p = 1.2 × 10 −17 ), blood glucose concentrations at each time were subjected to RMANOVA followed by Tukey’s test, as described above for AUC.

Using this approach, we found that the positive association between CAI and logPPR was highly significant ( G = 72.977, df = 1, P = 1.31e-17).

However, the effect, while highly significant ( p < 1.33 × 10 −17 ), is visibly small relative to the noise resulting in a small Cohen’s d effect size of 0.185.

The changes in AUC-ROC were not statistically significant (DeLong p -values of 0.922, 0.902, and 0.750 respectively); however, the McNemar test was highly significant ( p = 1.39 × 10 −17 , 5.23 × 10 −30 , 2.25 × 10 −24 ).

While platelet counts were positively associated with the PM (β = 0.29; P value = 8.23 × 10 –30 ; Additional file 6 : Table S5), the association between rs1354034 and the PM was still highly significant when conditioning on platelet counts (β = −0.33; P value = 1.40 × 10 –17 ).

This analysis yielded a highly significant positive relationship (P = 1.4 × 10 −17 , Fig. 6D ).

This statistical model was highly significant ( p = 1.468 × 10 -17 ).

A statistical comparison between pre-operative and 6-month follow-up Lysholm Scores using a paired t-test revealed a highly significant difference (t = 62.88, P < 0.0000000000000000154/P < 1.54 × 10 -17 ), indicating that the observed improvement in knee function was statistically significant.

(b) Comparing individual miRNAs in the training versus pseudo-training groups, 206 of 257 miRNAs on plate A (100 of 125 miRNAs on plate B) were expressed at higher levels in the training group; this was statistically highly significant ( P = 1.6×10 −17 ).