“highly significant”

Hub genes from PPI network Key targets were imported into the STRING database to construct a PPI network comprising 236 nodes and 3,711 edges, with highly significant enrichment ( p < 1.0 × 10 −16 ).

Cruise-specific calibrations of shipboard fluorometers, nephelometer/optical backscatter, and oxygen sensors yielded highly significant ( P <10 −16 ) linear relationships between all discrete and calculated concentrations of chlorophyll- a , SPM and DO ( Fig. 3 ).

The trend is weaker in lincRNAs compared with protein-coding genes (rho = 0.2 and 0.28, respectively) but both correlations are highly significant (from Spearman: P < 10 − 16 ).

These results show that all four topological measures provide highly significant ( p -value < 1e-16) enrichment in pathogen targets, with betweenness and clustering coefficient displaying highest enrichment, thereby demonstrating the added value of incorporating PPI data into inferred networks for a generalizable approach to identify target regulatory nodes within networks.

A highly significant correlation (half-life: Spearman's r = 0.67, P ≤ 1e -16 ; decay rate: r = 0.64, P ≤ 1e -16 ) was obtained, supporting the initial finding that RNA stability becomes more pronounced with increasing distance from the promoter.

Protein-protein interaction (PPI) analysis using STRING ( Szklarczyk et al., 2019 ) revealed that the hub proteins, including MSN, EZR, C1qa, a key component of the complement cascade, and GFAP, belong to a PPI network with highly significant interactions (p-value = 1.0e-16) ( Figure 4 B).

Initial mapping using an imputed genotype matrix for 2029 accessions (Togninalli et al ., 2018 ) revealed a highly significant peak associated with symptom score and total SA levels (−log 10 ( P ) = 15.96 and 10.64, respectively) spanning over 10 Kb on Chromosome 2 (Figs 1 , S2 for SA) and one marker reaching significance on Chromosome 3 (−log 10 ( P ) = 7.59) that is only associated with symptom score.

The M3 from the Japanese cohort wholly covered all the genes involved M11 from the TCGA cohort, which is highly significant overlap (n=41, hypergeometric test, P < 1.1e-16, Figure 2 g).

AgeAccelGrim remains a highly significant predictor of lifespan after restricting the analysis to never-smokers (N=3,988, meta analysis P=1.1E-16, Supplementary Fig. 9 ) or to former/current smokers (P=3.5E-33, Supplementary Fig. 3A ).

Irrespective of clades, all strains treated with 4 wt%Ag/TiZSM-5 zeolite and Ag-silicalite-1-nanomaterial showed highly significant inhibition for both biofilm [(24 h; F = 57.4079 and p = 1.1102 × 10 −16 ) (48 h; F = 43.3833 and p = 1.1 × 10 −16 ) and planktonic C. auris, compared to the control conditions.

It was found that the level of significance was highly significant ( P = 1.1102e-16).

The enrichment of SRCAP variants in the Caribbean Hispanic patients with LOAD was highly significant at p = 1.19e-16.

During the active period with lights off there was a highly significant difference between males and females (p = 1.3E-16) and also some difference between sites (p = 1.1E-3) with a significant interaction between site and sex (p = 3E-6) ( Fig 6a and 6b ).

As shown in Table 1 , the pMHCs that induced higher contact areas also induced more rapid initial spreading, although the initial spreading rate displayed only 1.8-fold variation depending on stimulation peptide, but peptide discrimination remained highly significant ( p = 1.3 × 10 −16 ).

This up-regulation was highly significant on meta-analysis (Fisher’s combined P = 1.4 × 10 −16 , Fig. 2C ).

Highly significant increases in median nFLAIR, CNI, and CCrI were observed for NAV→NEL ( p = 1.5 × 10 –16 , 2.4 × 10 –15 , 2.8 × 10 –16 , respectively) voxels compared to stable NAV voxels, while increases in median nADC also reached a statistical significance of p = 0.0009.

In the univariate model, PIP (chosen to represent all other heart rate fragmentation measures) demonstrated a highly significant ability to predict mortality (p = 1.71E-16).

After accounting for the general tendency for each participant to report higher or lower GAD-7 scores (Model 2), and adjusting for other covariates (Model 3), highly significant dose-response trends were evident (p < 2e-16 for each), adding 2–3 additional points to GAD-7 scores in highest categories of exposure ( Table 3 and S4 Table ).

However, the overlap between these two very different approaches is highly significant (Fisher's exact test, p < 2 × 10 −16 ), and the functional enrichments they identify are similar (see below).

Vials of APSA stored on ice in the fridge for up to 22 months and then sampled at a dilution factor of 1/250,000 (DF 250,000) prior to assay showed extreme sample to sample variation in enzyme activity and a trend to lower OD values over time with a highly significant effect of the storage time on the detection limit (ANOVA p ≤ 2E-16, Regression p < 0.043) ( Fig. 2 A).

The difference in this distribution was highly significant ( χ 2 p-value<2e-16).

Finally, LASSO analysis was not adjusted for age due to its high correlation with diagnosis (Pearson r = 0.74) and strong potential for solely predicting diagnosis, indicating a highly significant association (logistic regression estimate = 0.225, p < 2e‐16, Akaike information criterion [AIC] = 124,231).

The molecular essence of all samples was consistent between measurements on the solariX and scimaX systems, with ANOVA revealing highly significant differences among sample groups ( p < 2 × 10 –16 ).

We found 1341 of 4404 that passed QC in our own study (30.4%) were nominally associated with ethnicity (p<0.05), which represented a highly significant (p<2×10 −16 ) enrichment.

Evolutionary niche shift in response to the mean salinity The mean salinity experienced during evolution had a highly significant effect on acclimated tolerance surfaces ( P < 2 × 10 –16 , likelihood‐ratio test—hereafter LRT—between models with vs. without effects of salinity mean).