“highly significant”

We found the effect of rurality to be highly significant ( P < 2.0 × 10 -16 ), but it explains only 28% of the overall variation in log positional error magnitude.

The categorical, as well as the smoothed fixed, effects were all highly significant ( p < 2 × 10 − 16 ).

Data analysis showed a highly significant reduction of the average CpG methylation levels from 13.8% in control animals to 8.3% in KD samples over sixteen million mapped CpGs ( p < 2e-16, Wilcoxon rank sum test; Fig. 4a ).

The regression coefficients for height, weight, age and sex were all highly significant (p<2x10 -16 ) but none of the principal components for ancestry had a significant association.

8(B) ] by the end of D6, which was highly significant (χ 2 = 70.3, df = 1, P = 2.0E −16 , n = 32).

For males both age and puberty score were highly significant in predicting height at age 11 (r 2 = .17, p<2e −16 ) and 14 (r 2 = .23, p<2e −16 ).

As expected, the PY effect was highly significant (P < 2 × 10 −16 ), and the smoking group W5Y remained significant after correcting for PY (P = 0.008).

3 ), with a highly significant genotype effect ( p -value < 2 × 10 −16 ).

The first GLM, which included all values, returned a highly significant relationship between time spent in male germline and the observed substitution rates ( P < 2e-16; odd ratio 1.16, 95% CI: 1.1622–1.1626).

The variance analysis showed a highly significant municipality effect ( p < 2 × 10 −16 ), and the multivariable GLM confirmed strong spatial heterogeneity in TIR. 4.

Indeed, the fit of all points rather than of the medians were poor although the (anti-)correlation was highly significant (R 2 = 0.01, p < 2e −16 in both cases).

Notably, despite the absence of a significant indirect effect through AIP, TG exhibited a highly significant total effect on gout, driven by a strong direct effect independent of the AIP pathway (ADE = 0.1013, p < 2 × 10 −16 ) (Fig. 2 G, H, I, J) (File S1 : Table S13 – S17 ).

Logistic regression analysis showed that the correlation between the proportion of proplatelet-forming cells and RNA and protein levels for TPM4 was highly significant ( P < 2 –16 and < 6.23 –12 , respectively) ( Figure 8A ), demonstrating that the level of TPM4 is rate-limiting for platelet formation.

Females had significantly longer forearms (mean = 61.8 mm) than males (mean = 58.5 mm), with non-overlapping 95% confidence intervals and a highly significant t-test result (t = −12.68, p < 2 × 10 − 16).

In contrast, Sunitinib had a strong and highly significant effect on the fusion index of 54.12 cells at all concentrations tested (p<2 × 10 –16 ).

We observed that the A/I ratio was highly significant and associated with improved outcome (A/I ratio: HR = 0.77, P < 2x10 -16 ), while the total TIL score was associated with poorer outcome (TIL HR = 1.03, P = 0.0137).

To statistically confirm the effectiveness of this discrimination, we also conducted an ANOVA test, which showed a highly significant separation among the groups (F 2, 117 = 355.6, p < 2e –16 ).

The variation in ancestry seen in the admixture maps of Figure 1 also result in highly significant correlations of the three ancestries with altitude of birthplace (p-values <2×10 −16 for the three ancestries): African and European ancestry decreases with altitude (r of −0.24 and −0.39, respectively), while Native American ancestry increases (r = 0.48).

All p -values for the correlation coefficient are highly significant ( p -value < 2.0 × 10 −16 ).

Of these 316 genes, 81.5% (256) were found in our original list, a highly significant overlap ( P < 2 × 10 -16 , Fisher's exact test), demonstrating the reproducibility of our methodology.

The Shetland Sheepdog ranked second in all models, and both Collies and Shetland Sheepdogs were highly significant according to the logistic regression model ( p < 2 × 10 −16 ).

A model without interaction showed a highly significant effect of voxel on spectral quality ( Fig. 3 a ; F (1,79.12) = 183.73, p < 2 × 10 −16 ), with LO linewidth broader than EVC.

The differences between transdifferentiation factors and all other TFs are highly significant (one-sided Kolmogorov-Smirnov (KS) test, expression p-value<2*10 −16 ; H3K27me3 p-value<2*10 −16 ).

Distance to the sea is also highly significant (R 2 = 0.47, p <2e -16 for Tajima’s D).

All other pairwise comparisons were highly significant ( p < 2e-16 ).