“markedly significant”

18 Moreover, on clinical examination findings Jilani A et al., found hypotonia (p<0.0017) and early visual impairment (p <0.0001) to be markedly significant in patients with a molecular genetic diagnosis of NCL. 12 We also encountered hypotonia as a significant feature (p<0.001) along with early visual loss (p<0.0001) in patients of genetically proven NCL as compared to the patients with no molecular diagnosis.

Indeed, our flow cytometric analysis uncovered apoptosis induction upon Y 2 O 3 -NPs as manifested by the markedly significant ( P < 0.001) increase in early and late apoptosis in MDA-MB-231 cells (Fig. 5 A).

Sincerely, between two subgroups, there were markedly significant differences of BCRFS among training cohort ( p < 0.001), testing cohort ( p = 0.008), and validating cohort ( p < 0.001).

After analyzing viral pairings using Spearman’s correlation test, it was noted that SARS-CoV-2 was negatively associated with all other respiratory viruses, whereas a markedly significant positive correlation ( p < 0.001) was observed for five viral pairings (involving adenovirus/human bocavirus/human enterovirus/metapneumoviruses/rhinovirus).

This association remained markedly significant in the multivariate Cox model after controlling for age, gender, clinical stage, and mismatch repair (MMR) status (HR, 0.41 [95% CI: 0.30–0.57], P < 0.001; Figure 2B ).

Results Receptive and expressive language subscales of the K-BSID-III showed markedly significant correlation with the SELSI scores (p<0.001).

Postoperative pain and photophobia were milder in eyes with BCL compared with those without BCL ( P =0.04 and P =0.003, respectively), with fibrotic healing being markedly significant in the eyes with BCL compared with control eyes ( P <0.001) at 6 months.

Blood transfusion was markedly significant in IPVE (4 units (0–27) vs. 2 units (0–14); p < 0.001).

Figure 8b shows a markedly significant difference in RMS between the CR and PD groups ( p < 0.001).

The extracts olive biophenols showed markedly significant protection of SH-SY5Y cells at all concentrations tested ( p < 0.001) against l -DOPA induced toxicity.

In alignment with the GO analysis, the markedly significant pathways ( p < 0.001) encompassing bacterial ( Staphylococcus aureus ) infection (KEGG Pathway), innate immune response, neutrophil degranulation, immune system, post-translational protein phosphorylation, insulin-like growth factor transport and uptake (Reactome Pathway), and the complement system (WikiPathways) were predominantly associated with immune response (Fig. 3 b, Supplementary Table S5 ).

Comparing the two re-normalized fractional contributions for HeLa-wt and HeLa-APL-R cells, we found that the differences in both, α A and α B , determined for HeLa-wt and HeLa-APL-R cells are markedly significant (p < 0.001), with α B ≫ α A in HeLa-wt and α A ≫ α B in HeLa-APL-R cells, suggesting that APL * -B species seem to be critical for the mechanism of action of plitidepsin, while APL * -A species seems to be more related with cell defense against APL entry into cells.

Monoacylglycerols were the only lipid class displaying a markedly significant ( p < 0.001) decrease in CSF of MA patients as compared to CTRL subjects.

From a total of 120 patients, 64 (53.3%) were hypertensive, 39 (32.5%) had a positive family history and consequently they were markedly significant from selected control (neither hypertensive nor had a negative family history) ( P <0.001) and proving the risk for occurrence of MI.

When comparing the surgical degenerate cohort to the healthy samples, which showed an average 50% cell immunopositivity, a markedly significant difference was observed ( P ≤ 0.001) (data not shown).

The protective effect of glucocorticoids on mortality within 7 days was confirmed to be markedly significant (OR 0.22, CI 95% 0.12–0.38, p < 0.001) in a multivariate model that included age, SARS-CoV-2 infection, diabetes and cardiovascular diseases.

GSI and interpersonal sensitivity were found to be markedly significant (OR 12.87, 95% CI 3.96-41.78, P <.001; OR 23.18, 95% CI 5.35-100.46, P =.001) respectively.

The effect of group was markedly significant ( p < .001, η 2 = .087), but not the influence of CSF Abeta abnormality.

With regards to the average number of secretory granules of submandibular serous acini cells, there was a markedly significant decrease (p < 0.001) in the high-fat diet group (7 ± 2.3) compared to the untreated group (95 ± 4.6).

The relative mRNA expression levels of the Vg gene showed markedly significant differences between the treatment groups and the control groups collected on the days 9 ( F = 156.06 6; df = 3, 11; P < 0.001), 18 ( F = 131.693; df = 3, 11; P < 0.001), 26 ( F = 257.967; df = 3, 11; P < 0.001) and 32 ( F = 376.706; df = 3, 11; P < 0.001).The Vg mRNA expression levels in insects treated with 60 μg/mL Vg protein were 27-, 51-, 6-, and 2.5-fold higher than those of control groups on days 9, 18, 26, and 32, respectively.

NOx levels in PD patients (35.81±5.16 mol/L) were markedly significant compared to healthy subjects (11.27±3.59 mol/L) ( P <0.001) ( Fig. 3A ).

The difference in the percentage of cells displaying at least 5 Cyto-ID positive dots between healthy and RTT fibroblasts was markedly significant (80 ± 4% vs 8 ± 6%, respectively, p < 0.001).

While nonsignificant results were found for individuals with minimal concerns ( b = 0.08; odds ratio [OR] = 1.09, p = 0.791), markedly significant results ( p < 0.001) emerged for those expressing more concerns with b = 1.45 and OR = 4.28.

Furthermore, patients with abnormal levels of ≤2 metals showed a markedly significant ( p < 0.001) difference in overall survival outcomes compared to patients with abnormal levels of >3 metals (median survival: 41.72 vs. 19.13 months; Figure 4B ).

MDA, a primary indicator of lipid peroxidation, showed a markedly significant increase in gill tissue (5.43 ± 1.86 nmol/mg) compared to muscle tissue (4.07 ± 1.63 nmol/mg) ( p < 0.001).