“narrowly missed statistical significance”

When pooled, the overall HR was 0.88 (95% CI: 0.78–1.00), indicating a trend favoring ADCs over chemotherapy, although the result narrowly missed statistical significance ( p = 0.06).

4.2.3 ARNI in HFpEF The PARAGON-HF trial evaluated Sacubitril/valsartan vs valsartan in 4822 patients with HFpEF, and found reduced rates of the composite primary outcome of total hospitalisations for HF and death from cardiovascular causes (rate ratio 0.87), albeit this narrowly missed statistical significance (95% CI 0.75–1.01; p = 0.06) [ 29 ].

Local control was better in the TRT group, but the difference narrowly missed statistical significance (20% vs. 8.1%, p = 0.06).

The severe desmoplasia group also included a higher proportion of N1b patients, but this narrowly missed statistical significance ( χ 2 = 3.32; P = 0.06).

Additionally, in patients with compensated cirrhosis (MELD 10–17), autologous monocyte-derived macrophages demonstrated a favorable safety profile and clinical promising trends, including a reduction in MELD scores at day 90, a lower incidence of liver-related SAEs, and favorable anti-inflammatory cytokine changes, though the primary endpoint narrowly missed statistical significance (ΔΔMELD –0.87, p = 0.06).

Notably, two of the HFHC solvents (Calypsolv and EcoSolv) showed IL-8 dose–response curves strongly resembling ethanol’s pattern ( r ≈ 0.93), although correlations narrowly missed statistical significance ( p = 0.066), indicating a highly similar, though not conclusively identical, inflammatory response.

Although the primary composite outcome of all-cause mortality and heart failure events narrowly missed statistical significance (HR, 0.71; 95% CI, 0.49–1.03; p = 0.066), ablation-based rhythm control led to marked improvements in left ventricular ejection fraction, NT-proBNP levels, exercise capacity, and quality of life metrics compared to rate control [ 213 ].

Multivariate analysis further supported this trend, showing an AOR of 3.5 for SSI associated with staple use, though the result narrowly missed statistical significance (p = 0.07).

GPT4 Omni non-CE narrowly missed statistical significance ( p = 0.07) and showed considerably reduced sensitivity ( Table 3 ).

1.2%), but the difference narrowly missed statistical significance ( p = 0.073).

When including data from participants administered task order 2 also, there was a similar pattern of results although the relationship between temperature and age narrowly missed statistical significance (p = 0.08) (Supplementary Information S4 ).

A history of cancer also narrowly missed statistical significance (after PSM: OR 3.0, 95% CI 0.9–10.4, P = 0.08).

Compared to the minimally affected 2 MBq group, the 1 MBq group had significantly lower survival ( p = 0.0042), although it narrowly missed statistical significance compared to the 3 MBq group ( p = 0.808).

The moderating effect seemed bolstered when maternal negative IWMs of the child at both 16 months and at 3 years were high, although the difference in effects narrowly missed statistical significance, ΔB = 0.013, SE = 0.012, 95% CI [−0.002, 0.049].

The S 2 TOP-BLEED score at baseline was associated with more severe bleeding in both univariate and multivariate analyses, whilst the S 2 TOP-BLEED score on treatment was associated with more severe bleeding in univariate but narrowly missed statistical significance in the multivariate model.

Though it narrowly missed statistical significance, on multivariate analysis women were 16% more likely to receive a late diagnosis than men (95%CI OR0.84 (OR0.70 to 1.00).

3 In PARAGON-HF, which enrolled patients with HF and preserved ejection fraction, sacubitril/valsartan narrowly missed statistical significance for its primary end point. 4 However, a subgroup analysis suggested potential benefits in subjects with below-normal left ventricular ejection fraction.

The trial narrowly missed statistical significance for its primary endpoint of a composite of total hospitalizations for HF and death from cardiovascular causes ( Solomon et al., 2019 ).

In the subgroup without tophi, however, the reduction in SU narrowly missed statistical significance.

The latter group experienced improved outcomes, with a reduced rate of a composite outcome of death, MI and repeat revascularization, driven primarily by the latter two endpoints, both of which narrowly missed statistical significance on their own.

However, the obvious difference in patency rates narrowly missed statistical significance (Log-rank p = 0.071, Fisher exact p = 0.194), which was most likely due to the low number of grafts. 3.1.4.

Furthermore, our data show lower pyramidal symptom prevalence among the male subjects with the rs1801157 TT genotype when compared with the other genotypes, although the results narrowly missed statistical significance, possibly due to the rarity of this genotype in our sample.

However, the correlation with 1 year post‐discharge mortality narrowly missed statistical significance (log‐rank P = 0.066).

These associations narrowly missed statistical significance, and warrants further investigation.

5 In terms of clinical outcomes, two moderately sized randomized trials published prior to HEART‐FID (Ferric Carboxymaltose in Heart Failure with Iron Deficiency) demonstrated a reduction in HF hospitalizations and cardiovascular deaths in both hospitalized and stable patients which narrowly missed statistical significance. 6 , 7 The HEART‐FID trial further substantiated these results; thus, consideration of iron replacement in eligible patients with HF and ID is warranted. 8 , 9 The efficacy and safety of intravenous ferric carboxymaltose (FCM) has previously been demonstrated in multiple disease states (e.g. chronic kidney disease [CKD], inflammatory bowel disease, heavy uterine bleeding, postpartum period) including HF. 7 , 10 , 11 Prior studies with FCM have shown transient, asymptomatic hypophosphataemia.