Wilcoxon tests revealed significant differences in DNA methylation levels between the AF and SR groups at Site_1, Site_3, and Site_M (mean of the three sites) ( P < 0.05), while Site_2 showed non-significant but near-significant differences ( Figure 3G ).
We used a threshold value of 0.1 as exclusion criteria, which resulted in maintaining near-significant variables showing p-values between 0.05 and 0.1 in the model.
CD86 expression in primary CRCs showed no consistent associations with clinicopathological parameters, with only isolated near-significant findings.
Patients’ medication-related concerns did not contribute significantly to subgroup membership, whereas a near-significant association was found between patients’ beliefs about medication necessity and their membership of the benefit-driven subgroup (RRR: 1.12, 95% CI: 1.00–1.23).
It has been shown that greater adherence to LLDS is associated with lower systolic blood pressure and, in overweight and obese adults, a near-significant reduction in triglyceride levels, suggesting a protective effect against metabolic syndrome ( 7 ).
A near-significant relationship with surf zone SST was present for the body sizes of the largest males and females of E . braziliensis ( Fig 5F ) ( Table 1 ).
Similar patterns were observed for PROMIS pain interference, with greater improvements in the sublaminar group at the 2-week and 6-month time points, and a near-significant difference at three months.
Baseline regimen heterogeneity yielded no prognostic disparities except borderline biphasic dyskinesia modulation, with levodopa monotherapy patients showing enhanced post-switch gains; multivariable modeling confirmed PD duration as a near-significant covariate.
In addition, near-significant reductions in the per capita requisition of PC and per capita consumption of FFP were observed in this study.
This standard ensured that all significant and near-significant results were reported, and also that all other SNPs were known by the reader to be non-significant.
We also observed a near-significant increase in class-switched B220SP B2 cells in the brain, along with a decrease in naive B cells ( Figure 3H ).
However, when these SNPs were tested in the Follow-up group for replication, only three, PIP4K2A , FTO , and rs3846601, demonstrated significant or near-significant associations with consistent effect directions.
Constant peaks enriched for constant genes with a higher but near-significant p-value (P cons = 0.195) likely due to the low power arising from the small total number of genes and peaks within this trajectory.
In particular, our (near-significant) results regarding the analysis of adjuvant systemic treatment, as well as those of the separate analysis of subcohorts with different counts of treated metastases, could both benefit from larger sample sizes, in order to clearly define the potential influence of these factors on PFS and OS.
Although not statistically significant, the near-significant trend with cardiometabolic health aligns with emerging evidence linking poor oral health to systemic inflammation and cardiovascular risk [ 50 ].
Additionally, we performed a multivariate logistic regression analysis; the results indicated that while there was no significant effect of sex on the BA profiles, age may have an influence, as suggested by a near-significant difference(Table S4 ).
In this study, a near-significant difference in the use of colloid solutions was observed between the two groups, despite comparable total intraoperative fluid volumes and no statistically significant differences in intraoperative hemodynamic events.
On the other hand, a near-significant association with adjuvant mitotane use is indicative for drug-related genetic response.
There was a significant positive association between alpha power and GOS-E scores, and a near-significant negative association between delta variance and GOS-E, although the latter disappeared after accounting for clinically relevant covariates, such as age, sex, and sedation level.
No significant differences were found in AVLT measures of short-term memory span (the first trial), learning process (sum of tests 1–5), or general index of encoding and retrieval (correct answers in delayed free recall trial), which suggests that the 2 groups do not differ in episodic memory, although some near-significant subtle differences were observed.
With correction for main effects, PGMDR reports a different near-significant two-locus model involving rs2275703 in CASQ1 and rs1028583 in HNF4A .
Among the interaction terms, the most notable result was observed in Table 3 , where the T×ppm interaction contributed 23.83% to the model and had a p -value of 0.057, indicating a near-significant effect.
A statistically significant or near-significant difference in the number of attendees was observed in three of the thirteen themes.
Although the numbers were small, we were able to see near-significant differences between the PFS of MRD-negative cases and those who did not achieve or sustain MRD-negativity.
Demographic analysis revealed that sex ( p = 0.09) showed a near-significant difference, with more females receiving crisis counseling (67%) compared to males.