“nearly significant”

The above nearly significant interaction, when comparing the 50 vs. 100% treatments, is marginal in comparison to the differences in density across weeks ( z = −16.916, p < 2e-16).

We run a GWAS Cox model, with the first 10 PCs, age, age 2 , sex, period of infection and patient series as covariates and we found one variant (rs117011822) associated with survival at P -value < 5.0 × 10 −8 (genome-wide significance level) and another one (rs7208524) nearly significant ( P -value = 5.19 × 10 −8 ).

Interestingly, the OS genome-wide analysis identified 10 nearly significant variants (p value=6.3× 10 −8 ) on chromosome 2, in complete LD with each other ( figure 2 ).

Results Among pediatric subjects with WGS data, we identified a significant intronic variant in EDIL3 (rs149378, P = 1.9 × 10 −8 ) and a nearly significant intronic variant in LHX4 (rs79008224, P = 7.2 × 10 −8 ).

In addition, a large 1.4 Mb region at chromosome 17q21.31, coextensive with a known inversion polymorphism, 42 harbored 101 nearly significant SNPs (all P 's<10 −6 ; top SNP, rs916888, P =8.18 × 10 −8 ).

Two imputed SNPs (rs115231074: p = 1.3 x 10 −10 and rs35079132: p = 3.8 x 10 −8 ) achieved genome-wide significance, and one adjacent genotyped SNP was nearly significant genome-wide (rs4321864: p = 8.8 x 10 −8 ).

For example, there were significant associations between PTVs in PSAP and increased progranulin ( GRN ; P = 5.5 × 10 −17 ; β = 2.60; 95% CI, 1.99 to 3.21) and cathepsin B ( P = 1.2 × 10 −11 ; β = 2.10; 95% CI, 1.49 to 2.70), and a nearly significant association with increased cathepsin D ( P = 9.0 × 10 −8 ; β = 1.61; 95% CI, 1.02 to 2.20) (Supplementary Table 8 ).

For AMD, we identified one genome-wide significant locus in 18q22.2, rs12956753 (OR = 1.71, p = 3.76 × 10 −8 ), and another nearly significant locus in 15q14, rs138597498 (OR = 1.75, p = 1.02 × 10 −7 ), located near the genes DOK6 and DPH6 , respectively ( Figure 1 B).

27 Although the published FSHB promoter polymorphism was not the strongest signal in this region, it was genome-wide significant for association with LH in our data ( P= 4.84 × 10 −9 ), and nearly significant for FSH ( P= 2.31 × 10 −7 ) ( Supplementary Table 11 ).

Device and catheter type: multi-seal mechanism devices: ICE significantly shortened duration (MD = −3.46, P < 0.00001), whereas single-seal mechanism had superior TEE (MD = 2.56, P = 0.0002), with a significant between-group difference between devices ( P < 0.0001); SoundStar catheters: ICE significantly shortened duration (MD = −4.90, P < 0.00001), other catheter types had insignificant or nearly significant differences, with significant differences between groups ( P < 0.00001). 3.4.2.4 Summarize security results A total of 16 studies were included, containing 1,673 patients in the ICE group and 5,266 patients in the TEE group.

After collecting the candidate genes that were genome‐wide significant or nearly significant, we extracted SNPs with a GWAS p < 1 × 10 −5 and within 25 kb upstream or downstream of these genes.

Another haplotype located just 5′ to MSRA showed nearly significant over-transmission to individuals with MI, indicating that it conferred risk for MI (59 informative families, raw P = 1.99×10 −5 ; Bonferroni P = 0.057).

Among the 1509 successfully imputed SNPs in the SNCA locus, the strongest association was with rs2301135 (chr4:90,758,389, p = 5.68 × 10 −5 , OR = 1.40, minor allele C) and remained nearly significant after correction (threshold p < 3.3 × 10 −5 ) using conservative multiple test assumptions of independent SNPs.

For falling number, a nearly significant region was found on chromosome 7B ( p -value = 4.3 * 10 −5 ) with an allele frequency of 89% for the advantageous allele (Figure 5D ).

Among these, CD2 and CD80 , which contain nearly significant ( P <1.00×10 -4 ) SNPs ( rs13904539 , rs13904683 and GGaluGA032608 ) for the antibody response to NDV, belong to the cell adhesion molecules pathway (gga04514), which involves the major histocompatibility complex (MHC) and T cell receptor genes.

In each group, the mean IOP decreased significantly after Needling, except in the NPDS-Phakic group, which was nearly significant (Phaco-NPDS p<0.0001, NPDS-IOL p<0.0001, and NPDS-Phakic p=0.06).

The nearly significant correlations were obtained between miR-9 and miR-205 (r = 0.13, p-value < 0.0001), between miR-9 and miR-192 (r = 0.08, p-value < 0.0001) and between miR-192 and miR-205 (r = 0.71, p-value = 0.001) in the serum samples of the precancer groups.

In this group, mToT, mPFS, and mOS were 151, 199, and 578 days, respectively, compared to 258, 322, and 748 days in the RDI below 85%, respectively; these differences were significant or nearly significant in all studied endpoints ( p < 0.0001; 1 yr ToT OR 0.20 (95% CI: 0.12–0.34), p = 0.0002; 1 yr PFS OR 0.38 (95% CI: 0.26–0.56), and p = 0.0728; 2 yrs OS OR 0.58 (95% CI: 0.39–0.85), respectively).

A post hoc test found no significant differences between NA males and females or CR males and females reared in either season, though the difference between CR males and females was nearly significant in autumn (Kruskal–Wallis χ 2 = 38.67, df = 7, p < .0001, Dunn test with Bonferroni correction, NA: p = .88, p = 1.0, CR: p = .48, p = .08, summer and autumn, respectively).

Although the p values for F IS in the seven populations were not significantly different from zero after adjusting according to the nominal level ( p = 0.00036), the p values for F IS in five populations (LHG, NLG, WGG, YLG, and ZTG) were nearly significant ( p = 0.0004).

Moreover, this parameter was significantly higher in PLNKO than in WT and nearly significant in SDKO myocytes versus S2814D myocytes, reaching significant levels when compared by unpaired Student’s t test (P = 0.0006), as expected by ablation of PLN ( Luo et al., 1994 ).

Multinomial regression demonstrated the impact of nPCR at each level of increment of albumin of 0.1 g/dl from 1.9 to 4.1 g/dl when fever, days in hospital, bacteremia, and dry weight change, age (decile), sex, phosphorus, and WBC counts, the factors shown by Pearson correlation to be significant or nearly significant, were taken into account (p < 0.001).

At least one difference in allele frequency between groups was significant, or nearly significant, for the PNPLA3, TM6SF2, and KLF6 variants ( p < 0.001, p < 0.05, and p = 0.06, resp.), and a risk score based on these SNPs was generated.

A comparison between the groups showed significant differences in the strength of the effects between the CG and the TCG for work engagement [CG: β = 0.86, p < 0.001, TCG: β = 0.59, p < 0.01, p(∆χ 2 ) = 0.011] and emotional exhaustion [CG: β = 0.82, p < 0.001, TCG: β = 0.60, p < 0.01, p(∆χ 2 ) = 0.037] and a nearly significant difference between the CG and the TG for emotional exhaustion [TG: β = 0.68, p < 0.001, p(∆χ 2 ) = 0.065].

Two-way repeated analyses of variance (ANOVAs) with within-participant factors of target distance and trajectory for each target type revealed significant or nearly significant main effects of distance for all target types (T: F 1,9 = 42.27, p < 0.001, η G 2 = 0.041; VT: F 1,9 = 11.21, p = 0.009, η G 2 = 0.040; V: F 1,9 = 4.11, p = 0.073, η G 2 = 0.028) and trajectories (T: F 1,9 = 4.79, p = 0.056, η G 2 = 0.013; VT: F 1,9 = 4.10, p = 0.073, η G 2 = 0.006; V: F 1,9 = 10.16, p = 0.011, η G 2 = 0.021).