“nominally significant”

In the prelimbic cortex, there was a nominally significant difference in Gdap1 DNAm ( F (1,29) = 4.92, p = 0.035, mean ± SD DNAm AUD = 4.07% ± 0.41%, mean ± SD DNAm Ctrl = 3.66% ± 0.59%, Figure 6 E).

The difference in the proportions of patients with ≥1 TEAE (10.3%; 95% confidence interval, −0.3% to −21.0%) was nominally significant ( P = .0355).

Furthermore, a positive correlation between the 5-year mean IGF-1 SDS and the duration of GHRT was nominally significant (r = 0.421, p = 0.036).

PLEKHA1 showed a nominally significant MCI versus CN difference (T = 2.11, P = 0.036, FDR P = 0.225), and TBK1 did not reach significance ( Supplementary Table S28 ).

In contrast, the TimePeriod × Sex interaction was not consistent: it was not significant for PC1–PC5 or PC1–PC8 but became only nominally significant when additional low‐variance PCs were included (PC1–PC10 and PC1–PC12; p = 0.036 and 0.044) (Table S9 ).

The inverse variance weighted (IVW) analysis indicated a nominally significant association between genetically predicted depressed affect and DKD (OR: 2.452; 95% CI: 1.061–5.671; p = 0.036), while the weighted median method also yielded a statistically significant estimate (OR: 3.709; 95% CI: 1.146–12.003; p = 0.029).

For phylum Euryarchaeota (id.55), weak but nominally significant associations with dysmenorrhea were observed in the IVW analysis (β = −0.409; 95% CI: −0.793∼−0.025; P = 0.036), with directionally consistent estimates across IVW, MR-Egger, and Weighted Median.

Lateralization analysis Our lateralization index (LI) analyses revealed a nominally significant association between insight propensity and leftward FA asymmetry in the dorsal composite (β_std = 0.323, p = 0.036), however this effect did not survive FDR correction ( q = 0.216).

In the forest plot summary ( Figure 4 G), the IVW estimator yielded a nominally significant association ( p = 0.0361), with an OR of 0.9961 (95% CI: 0.9925–0.9997).

A nominally significant association with bleeding risk persisted only for rosuvastatin (OR = 2.189; 95% CI: 1.039–4.612; p = 0.037), but this finding should be interpreted with caution and regarded as exploratory. 3.4.

The only nominally significant result that survived qPCR confirmation was detected for a duplication on chromosome 15q11.2 affecting up to five genes, including NIPA1 and CYFIP1 ( P = 0.037).

A nominally significant interaction effect was observed in patients with hypertension ( P = 0.037) and in those with wide QRS ( P = 0.003) ( Table 6 ).

For the previously reported SNP rs9939609 identified by GWAS for obesity phenotypes [9] , [10] , [11] , we only detected nominally significant association with spine BMD in the Chinese sample 1 ( P = 0.037).

Of ten transcripts, only HAND2 showed a nominally significant reduction in APL+ women (median ΔCt −2.04 vs. −1.30; p = 0.037; rank-biserial r = −0.47); this signal did not survive Benjamini–Hochberg correction (q = 0.372).

The linear effect for Existence was nominally significant, b = −0.107, p = .037, but was not significant after FDR correction, p FDR = .130.

The combined haplotype GGT, consisting of all three risk alleles, was associated with PEX (p=0.037, nominally significant), conferring a 1.8-fold of increased risk of the disease (OR=1.8, 95% CI=1.03–3.28; Table 3 ).

Perhaps in line with this idea, we did see a nominally significant benefit of vitamin D on biological age ( p = 0.037) before correcting for multiple testing.

For primary anxiety response, those defined as responders at follow-up showed a small increase in SERT methylation during the treatment period (from pre- to posttreatment, +1.1%) at CpG site 4, whereas nonresponders showed a larger decrease in methylation (nominally significant;−5.9%, t (91)=2.114, P =0.037, d =0.499; see Figure 1a ).

An initial synthesis of the volume data from the left and right habenula using a paired samples t ‐test also supported this point: no significant interhemispheric differences for either the healthy samples ( t (24) = 1.443, p = .162, Cohen d = 0.289), or the patients with SCZ ( t (4) = −0.550, p = .612, d = −0.246); there appeared to be a nominally significant difference in MDD subgroup ( t (10) = 2.403, p = .037, d = 0.725), but it did not survive correction of multiple testing.

Similarly, the conditional multivariable MR association of IL-6 on AN is only nominally significant (OR = 0.96, [95% CI = 0.93–0.99], P = 0.037).

In contrast, the probabilities of transitioning from other PL states to PL state 3 were all increased, with the transition from PL state 4 to PL state 3 also showing a nominally significant difference (uncorrected p = 0.0376, Cohen’s d = 0.5201).

MR pleiotropy residual sum and outlier (MR-PRESSO) test identified 5 outliers for IBD, 1 for RA and 2 outliers for vitiligo ( Table S10 ), whereas exclusion resulted in a nominally significant association for vitiligo (OR, 95% CI: 0.827, 0.691–0.989), p -value = 0.038; Figure 4 a).

Longitudinal stratification of the CIPN phenotypes to examine links for neuropathy, identified nominally significant protective associations with the GSTM* null allele ( p -value = 0.038, OR = 0.55) and the presence of pain at month 2 of treatment, as well as a risk factor for pain related month 2 of treatment for individuals with the GSTT1* null allele ( p -value = 0.030, OR = 1.64).

When tested individually, both di- and tetranucleotides showed at least nominally significant signals (two-sided z -proportion test P = 0.038 and P = 3.7 × 10 –38 , respectively), but trinucleotides did not ( P = 0.95).

PERMANOVA analyses identified nominally significant effects of Age within the ONT dataset at the phylum (R2 = 0.204, p = 0.038), family (R2 = 0.154, p = 0.020), and genus (R2 = 0.139, p = 0.029) levels, whereas no nominally significant effects were detected in the Illumina dataset (Supplementary Table S2).