“nominally significant”

We detected 34 nominally significant differentially methylated regions (DMRs) ( p < 0.05, methylation difference > 10%), that included both hyper- and hypo-methylated loci ( Supplementary File S5 ) ( Figure 9 A).

Common variants associated with Alzheimer’s disease were not enriched in genes with high expression specificity for any hippocampal subregion, showing nominally significant enrichments (uncorrected p < .05) only in the choroid plexus and white matter.

None of the individual SNPs in the CCT-GRS were associated with OAG after correction for multiple testing, however 10 SNPs were nominally significant ( P < 0.05 uncorrected for multiple testing; Supplementary Table S5 ).

Linear regression analysis revealed nominally significant association ( P < 0.05, without multiple testing correction) between SNPs in the 20 kb region flanking ARC and the visuospatial ability subset, delayed episodic memory, and episodic memory (Table 4 ).

Furthermore, for the single variants within these genes that were nominally significant ( p <0.05) in the FinnDiane WES/WGS meta-analysis, we tested for replication in the FinnDiane, THL Biobank, FinnGen GWAS and TOPMed WGS data.

In patients with moderate or severe DED ( n = 53), PL9643 treatment demonstrated either nominally significant ( P < 0.05) or trending ( P < 0.1) improvement over placebo in mean change from baseline at week 12/day 85 in several sign endpoints, including fluorescein staining in inferior, superior, corneal sum, and total sum regions; Lissamine Green staining in temporal, nasal, conjunctival sum, and total sum regions; and tear film breakup time.

While the breast cancer pathway was significantly enriched (FDR < 0.05) in all other tissue types, it was only nominally significant in breast tissue (unadjusted P < 0.05).

All loci identified here were directionally consistent, nominally significant with “rapid3” and/or “CKDi25” (one-sided P<0.05) and two were genome-wide significant for rapid3 or CKDi25 ( UMOD - PDILT , PRKAG2 - GALNTL5 ).

Overall, 11/17 (65%) associations were nominally significant at p<0.05, 9/17 (53%) at p<0.001.

For the new AF data, we used the same IVs as in the discovery analysis, and finally 4 of the 10 proteins (COF2, RAB1A, TNF12, and COFA1) showed significant associations with AF risk ( P <0.05/10), and 2 proteins (ANXA4 and QSOX2) showed nominally significant associations with AF risk (0.05/10< P <0.05) (Table S7 ).

Examining genes nominally significant ( p -value < 0.05) in only one myocardial layer indicates distinct regional responses.

Some nominally significant correlations (uncorrected p < 0.05) were also observed in AN and BN groups (details in the Online Supplementary Material, Tables S1-S3).

From the 20 potential loci identified from the secondary posterior effects analysis, 75% of these (15/20 loci) displayed a concordant direction of effect in the independent replication set, three of which were nominally significant (p < 0.05): 2p25.3, 11q13.1 and 12p12.1.

Gene-Level Enrichment Analysis via MAGMA Using the FUMA platform with MAGMA for gene-based analysis, we identified 3727 nominally significant genes (P < 0.05).

Of the 174 lead SNPs identified in the discovery cohort, 145 (83.3%) remained nominally significant ( P < 0.05) in this replication dataset.

To identify metabolomic biomarkers independent of conventional risk factors including DKD, metabolites remaining nominally significant ( p <0.05) after further adjusting for CKD and severely increased albuminuria were assessed for the prognostic value.

Variants with FDR < 0.05 in at least one source were confirmed as nominally significant ( p < 0.05) with consistent effect direction in the other available data sources.

Fourteen out of twenty-eight selected SNPs showed nominally significant associations at p <0.05 with different dimension-specific quantitative assessments of psychotic experiences but each failed to meet statistical significance post correction for multiple testing ( p <0.0008; one-tailed).

Considering only the biological N of 2 (two independent grow-ups of each strain, distinct from those initially screened in microarrays), and not the technical duplication of assays for each of those, 10 of the 18 genes assessed showed allele-dependent changes that were nominally significant ( P ≤ 0.05), whereas no more than one would be expected by chance (Table 3 ).

In contrast, the waiting group exhibited nominally significant within-group longitudinal changes in FC for 10 channel pairs before FDR correction (paired t -tests: 0.01 < p < 0.05), visualized in Figure 5 C.

Baseline abundances of Bifidobacterium genera and species ( Bifidobacterium longum and Bifidobacterium bifidum ) tended to be higher in participants with the greatest improvements in letter retrieval scores with FBB supplementation (nominally significant, P < 0.05) .

Pearson correlation and group-based comparisons identified ten compounds with nominally significant associations associated with CDH2 expression ( p < 0.05) ( Figure 10 ).

Out of 27 SNPs, correlation with absolute latitude was nominally significant (p < 0.05) for 13 of them.

Among the pAIDs examined where the SNP- h 2 estimates were at least nominally significant ( P <0.05), T1D and juvenile idiopathic arthritis (JIA) were the most highly heritable ( Fig. 1b ).

Of the 1,291 adult BMI variants compared, 395 variants (31%) were nominally significant ( p < 0.05) and 949 (74%) displayed directionally consistent associations with childhood BMI, which was far greater than would be expected by chance ( p < 0.001) ( Table S6 ).