“nominally significant”

Fourteen out of twenty-eight selected SNPs showed nominally significant associations at p <0.05 with different dimension-specific quantitative assessments of psychotic experiences but each failed to meet statistical significance post correction for multiple testing ( p <0.0008; one-tailed).

Of the 1,291 adult BMI variants compared, 395 variants (31%) were nominally significant ( p < 0.05) and 949 (74%) displayed directionally consistent associations with childhood BMI, which was far greater than would be expected by chance ( p < 0.001) ( Table S6 ).

All loci identified here were directionally consistent, nominally significant with “rapid3” and/or “CKDi25” (one-sided P<0.05) and two were genome-wide significant for rapid3 or CKDi25 ( UMOD - PDILT , PRKAG2 - GALNTL5 ).

Given the exploratory nature of the study, p-values were considered nominally significant at p < 0.05 without correction for multiple comparisons.

Pearson correlation and group-based comparisons identified ten compounds with nominally significant associations associated with CDH2 expression ( p < 0.05) ( Figure 10 ).

63 inferential comparisons were evaluated; 38 were nominally significant at p < 0.05, and 35 remained significant after Benjamini–Hochberg FDR correction (q < 0.05).

Tier 1 findings included putative causal associations from the main analysis, which were directionally consistent, at least nominally significant in all analyses and showed no evidence of pleiotropy, that is, the Egger intercept P value >0.05, whereas tier 2 included the remainder of putative causal associations from the main analysis.

However, each of the experiments revealed 100–400 genes with nominally significant changes in gene expression ( p < 0.05).

We reported genetic associations that were nominally significant ( P < 0.05) and directionally consistent with observational findings.

Among the pAIDs examined where the SNP- h 2 estimates were at least nominally significant ( P <0.05), T1D and juvenile idiopathic arthritis (JIA) were the most highly heritable ( Fig. 1b ).

Results from PrediXcan 30 (in blood) supported our hypothesis that parents would have higher predicted gene expression than their children when testing dominant and recessive DD genes containing putatively damaging PTVs, but this result was only nominally significant and did not pass multiple testing correction ( p < 0.05) (Supplementary Fig. 9 ).

Nevertheless, the sign and estimates of the effect sizes were all consistent, and most of the relevant associations were found nominally significant (P < 0.05).

While these results were nominally significant (p < 0.05), they did not maintain statistical significance after Hochberg correction.

Discussion In a population with chronic mental illness, various SNPs in 10 candidate genes ( PPP1R1B , BDNF , DRD3 , DRD2 , HTR2A , HTR2C , COMT , MnSOD , CYP1A2 , and RGS2 ) reached nominally significant (p≤0.05) associations with drug-induced movement disorder.

Differential abundance analysis identified 98 metabolites with nominally significant differences ( p < 0.05), though none survived FDR correction (0.238 < q < 0.296), likely reflecting the modest sample size.

To identify metabolomic biomarkers independent of conventional risk factors including DKD, metabolites remaining nominally significant ( p <0.05) after further adjusting for CKD and severely increased albuminuria were assessed for the prognostic value.

Similarly, urinary DAP metabolite concentrations, including DEP, DETP, DMDTP and DEDTP, showed nominally significant associations ( p < 0.05) with at least one of these two outcomes.

Including the quadratic age term as an additional confounder further reduced the t 0 -MD correlation ( r = 0.13, p = 0.05, df = 225), but somewhat strengthened the g F-MD correlation ( r = −0.20, p < 0.01, df = 221), and also made the DSS -MD correlation nominally significant ( r = −0.15, p < 0.05, df = 196).

Of the nominally significant single‐cell SMR associations ( P <0.05), >75% (Figure 2E ) were not detected in the corresponding GTEx brain tissue SMR analyses.

Plasma NFL alone (Pathway 3) showed nominally significant mediation effects for ADAS13, CDRSB, MEM, and LAN (total indirect effect: all uncorrected P < 0.05) ( Figure 2IV .A, B; Table S9); however, after FDR correction, only the mediation effect on MEM remained significant ( P < 0.05).

Gene set enrichment analyses Enrichment analyses of Gene Ontology (GO) terms [ 45 ] and Reactome pathways [ 46 ] were performed in g:Profiler [ 47 ] with nominally significant ( p < 0.05) genes derived from the cross-ancestry, gene-based meta-analysis.

Based on the criteria aforementioned (Table 1 ), most of the main associations (87%) showed nominally significant results ( p < 0.05).

Most local edges were consistent, though the edge between fruit and vegetable intake and aerobic physical activity showed a nominally significant difference at α = 0.05 level ( p < 0.05).

We found that 18 of the 108 proteins investigated were influenced by storage time (Supplementary Table 1, nominally significant, p < 0.05), and one protein (Cancer antigen 125; CA-125 also known as Mucin 16) remained statistically significant after correction for testing of multiple hypotheses (Bonferroni, p < 0.05/108 = 4.6 × 10 − 4 ).

We found that four SNPs showed nominally significant associations at P <0.05 for rs26232 ( C5orf30 ), rs2073838 ( SLC22A4 ), rs11676922 ( AFF3 ), and rs7528684 ( FCRL3 ).