“nominally significant”

While these results were nominally significant (p < 0.05), they did not maintain statistical significance after Hochberg correction.

All the nominally significant genes ( P < .05) of differential expression with BMD in Chinese are summarized in Table 2 .

We detected 34 nominally significant differentially methylated regions (DMRs) ( p < 0.05, methylation difference > 10%), that included both hyper- and hypo-methylated loci ( Supplementary File S5 ) ( Figure 9 A).

Only behavioral measures showing a nominally significant association ( p < 0.05) with the same PRS factor in all three analytical scenarios (primary, updated GWAS, and PRS‐CS) were carried forward to the mediation analysis.

Enrichr analysis Zebrafish genes identified in the RNA-seq analysis that showed nominally significant ( p < 0.05) expression change between WT and mgt −/− samples were converted to their human orthologues using the HUGO Gene Nomenclature Committee (HGNC) HCOP tool and the ZFIN database [ 45 ].

The effect of p-tau 181 on the volume of the right hippocampus remained significant ( β = −0.23, P = 4.23e-04, P FDR = 0.053), but no interactions were nominally significant ( P > 0.05; Supplementary Table 7 ).

A list of observed DNA variants and their effect on the hepatic copper score is presented in Table 1 . The five nominally significant variations ( P ≤0.05) were genotyped in an independent cohort of 59 Labrador retrievers ( Table 1 ; Table S1 ).

We found that 18 of the 108 proteins investigated were influenced by storage time (Supplementary Table 1, nominally significant, p < 0.05), and one protein (Cancer antigen 125; CA-125 also known as Mucin 16) remained statistically significant after correction for testing of multiple hypotheses (Bonferroni, p < 0.05/108 = 4.6 × 10 − 4 ).

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

The following criteria were used to determine the differential abundance of proteins in the septic/aseptic group: (i) proteins that were identified in at least 60% of the samples in at least one group and (ii) for which a nominally significant difference in protein abundance was observed between conditions (unadjusted p < 0.05).

Differential gene expression analyses of CD11b + cells in VAT and SAT from individuals with obesity revealed nominally significant differences in the gene expression profile (FDR p < 0.05, absolute fold change > 1.5; Figure 1A,B ).

Although there was a nominally significant main effect of instruction, t (25.96) = 2.09, p = .05, there were no significant interactions involving instructions.

We found that four SNPs showed nominally significant associations at P <0.05 for rs26232 ( C5orf30 ), rs2073838 ( SLC22A4 ), rs11676922 ( AFF3 ), and rs7528684 ( FCRL3 ).

Gene set enrichment analyses Enrichment analyses of Gene Ontology (GO) terms [ 45 ] and Reactome pathways [ 46 ] were performed in g:Profiler [ 47 ] with nominally significant ( p < 0.05) genes derived from the cross-ancestry, gene-based meta-analysis.

Of the nominally significant single‐cell SMR associations ( P <0.05), >75% (Figure 2E ) were not detected in the corresponding GTEx brain tissue SMR analyses.

Of the 21 loci, 13 were nominally significant (p<0.05) in UKBB, including one variant (rs4388642 in CFH, p=1.82×10 -17 ) reaching Bonferroni-corrected significance (Supplementary file Table S3).

Pathway analysis performed in Metaboanalyst using all nominally significant metabolite changes ( P ≤ 0.05, FDR < 0.2) after loss of frataxin revealed effects on arginine biosynthesis, alanine metabolism, TCA cycle, taurine metabolism, and glutathione metabolism with many of the changes common among the heart, cerebellum, and mitochondria ( Supplemental Table 2A ).

The rs1046322 and rs9457 polymorphisms showed nominally significant ( p < 0.05) association in all three (type 1, type 2 and combined) analyses, which remained significant in all cases after FDR correction for multiple testing.

For this purpose, we extracted information on CpGs from each study that met methylome-wide significance as defined by that study’s criterion (e.g., Bonferroni, false discovery rate or FDR) or were nominally significant (p < 0.05).

Although the FHV-I-FPV pair had the highest odds ratio (OR = 2.93) and the corresponding Fisher’s exact test yielded a nominally significant p value ( p < 0.05), after Bonferroni multiple testing correction (correction factor k = 6), none of the pairwise pathogen co-infection associations remained statistically significant (adjusted p > 0.05).

In total, 28 genes in the European-American sample and ten genes in the African-American sample were nominally significant (i.e., the observed test statistic differed from neutral expectations at p < 0.05) in one or more tests of the allele frequency distribution ( Figure 1 ).

Although no striatal gene expression changes reached significance following FDR correction (FDR <0.1) in HTT-ASO-treated YAC128 mice at the 6-month time point, we identified 105 downregulated and 148 upregulated genes that were nominally significant ( p < 0.05) in response to treatment ( Table S2 ).

We note that although APOE has previously been identified as a AD TWAS gene in microglia 83 , we did not highlight it in our scTWAS results because it did not pass Stage 1 screening, despite nominally significant Stage 2 associations in proliferate, surveilling, and reacting microglia (nominal p -values < 0.05).

However, within specific strata, exploratory observations showed nominally significant negative correlations ( P < 0.05) in participants with/without health insurance, among Other Hispanic individuals, and in those with low neutrophil counts, low SII/AISI scores, or pre-frailty/frailty status, both before and after adjusting for age, household education, and PIR (Table S4).

Both these SNPs were nominally significant (p<0.05) within males and females, however sex did not modify the association.