“nominally significant”

To identify metabolomic biomarkers independent of conventional risk factors including DKD, metabolites remaining nominally significant ( p <0.05) after further adjusting for CKD and severely increased albuminuria were assessed for the prognostic value.

The case-to-control correlation difference network includes nominally significant links ( p < 0.05), whenever correlation was significant in cases and/or controls ( p < 2 × 10 –5 ).

Fourteen out of twenty-eight selected SNPs showed nominally significant associations at p <0.05 with different dimension-specific quantitative assessments of psychotic experiences but each failed to meet statistical significance post correction for multiple testing ( p <0.0008; one-tailed).

Of the 174 lead SNPs identified in the discovery cohort, 145 (83.3%) remained nominally significant ( P < 0.05) in this replication dataset.

Improvements in MADRS total score at Day 15 were observed in all 5 studies and were nominally significant (p < 0.05) versus placebo in 4 studies ( Fig. 1 ).

These correlations remained nominally significant (p < 0.05), aside from DunedinPACE and Horvath age acceleration. 3.3.

Pearson correlation and group-based comparisons identified ten compounds with nominally significant associations associated with CDH2 expression ( p < 0.05) ( Figure 10 ).

According to BADGERS, the reference panel comprises 1738 traits from the UKB 17 , selected on the basis of nominally significant SNP-based heritability ( P < 0.05).

However, four other genes-ureA, ureC, gdh_k15371, and nosZ-which showed nominally significant differences in raw p - values (all P < 0.05), did not retain statistical significance after FDR correction (all q > 0.05).

Tier 1 findings included putative causal associations from the main analysis, which were directionally consistent, at least nominally significant in all analyses and showed no evidence of pleiotropy, that is, the Egger intercept P value >0.05, whereas tier 2 included the remainder of putative causal associations from the main analysis.

These analyses identified 3,436 genes with nominally significant differential expression in any contrast related to sex and play ( p < 0.05).

Among the pAIDs examined where the SNP- h 2 estimates were at least nominally significant ( P <0.05), T1D and juvenile idiopathic arthritis (JIA) were the most highly heritable ( Fig. 1b ).

Associations of Gut Fungi with Postprandial Glycemic Responses to Dietary Intervention We found 12 nominally significant associations between the above-identified gut fungi and glycemic metrics ( p < 0.05, Supplementary Tables S8 and S9 ).

While these results were nominally significant (p < 0.05), they did not maintain statistical significance after Hochberg correction.

Discussion In a population with chronic mental illness, various SNPs in 10 candidate genes ( PPP1R1B , BDNF , DRD3 , DRD2 , HTR2A , HTR2C , COMT , MnSOD , CYP1A2 , and RGS2 ) reached nominally significant (p≤0.05) associations with drug-induced movement disorder.

The higher relative abundance for these taxa was nominally significant in carriers ( P ≤ 0.05), but non-significant after correction for multiple testing which is not unexpected given the small sample size.

Nevertheless, the sign and estimates of the effect sizes were all consistent, and most of the relevant associations were found nominally significant (P < 0.05).

In contrast, the waiting group exhibited nominally significant within-group longitudinal changes in FC for 10 channel pairs before FDR correction (paired t -tests: 0.01 < p < 0.05), visualized in Figure 5 C.

For each gene, the genotype score for a randomly chosen common SNP (common variant genotype score, CVGS) was regressed on the unweighted sums of genotype scores for all rare SNPs in the gene (sum of rare variant genotype scores, SRVGS), and the frequency of nominally significant ( P < 0.05) regressions was recorded.

Gene set enrichment analyses Enrichment analyses of Gene Ontology (GO) terms [ 45 ] and Reactome pathways [ 46 ] were performed in g:Profiler [ 47 ] with nominally significant ( p < 0.05) genes derived from the cross-ancestry, gene-based meta-analysis.

A list of observed DNA variants and their effect on the hepatic copper score is presented in Table 1 . The five nominally significant variations ( P ≤0.05) were genotyped in an independent cohort of 59 Labrador retrievers ( Table 1 ; Table S1 ).

As most results were nominally significant (P < 0.05) but did not meet the stringent corrected threshold (P < 0.005), they are cautiously interpreted as indicating potential trends in the discussion of our findings.

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

Of the nominally significant single‐cell SMR associations ( P <0.05), >75% (Figure 2E ) were not detected in the corresponding GTEx brain tissue SMR analyses.

The strongest haplotype effects were observed on HDL-C, followed by ApoB, comprising 19 and 18 nominally significant ( P <0.05) global P -values, respectively ( Supplementary Table 11 ).