“nominally significant”

On the other hand, among the 986 SNPs with estimated PPR >99%, 47% were nominally significant with p < 0.05 in the replication cohort 23andMe, and 79% with consistent direction of effects.

The differences in allele and genotype frequencies between ALL cases and controls were nominally significant (P < 0.05) for 20 SNPs.

The criteria for a highly suggestive association were met if: P < 10 −6 , >1000 participants, and largest study in the meta-analysis presenting nominally significant estimate (i.e., P < 0.05).

A total of 19 HLA alleles had nominally significant maternal and/or fetal effects on BW ( P <0.05; Supplementary Table S7 , available as Supplementary data at IJE online); 13 of the 19 alleles had evidence for a maternal effect only, four alleles primarily had evidence for a fetal effect only and two alleles had evidence of both.

To determine if any annotations were enriched in both mouse and human, even though individual genes were not shared, separate lists of genes nominally significant in human (915 genes p ≤ 0.05) and human homologues of the 42 mouse genes with p ≤ 0.05 were entered into DAVID.

The sentinel variant rs62040020, which resided within an intron of Jupiter microtubule associated homolog 2 ( JPT2 ) on chromosome 16 (effect allele frequency (EAF)=10.6%), was measured in all six studies with a high imputation quality (r 2 >0.88 across all six studies) and was nominally significant (p<0.05) in four of the six studies ( supplementary table 2 and figure 4 ).

To observe overall genetic control of gene expression in a disease context, we intersected all cis-eQTL results with the nominally significant GWAS SNPs ( p < 0.05) [ 8 ] and plotted the p values from the two sets (Fig. 2 ).

Finally, we used the excess significance test to evaluate whether the observed number of studies in the meta-analysis that presented a nominally significant result ( P -value < 0.05) was different from the expected number of studies with significant results [ 22 ].

However, four other genes-ureA, ureC, gdh_k15371, and nosZ-which showed nominally significant differences in raw p - values (all P < 0.05), did not retain statistical significance after FDR correction (all q > 0.05).

While only nominally significant at p < 0.05, there was preliminary indication of differential methylation of genes involved in GTPase activity (GO ID:0090630) and cell-cell adhesion (GO ID:0098609) (See Supplementary material).

All these effects survived Bonferroni correction – additional, nominally significant results ( p < 0.05 threshold) are flagged in Table 3 .

Results A total of 214 SNPs from the PIP2 hydrolysis pathway had nominally significant ( P < 0.05) POE on T2D, among which rs199684931 (RR m /RR p = 0.28, P interaction = 0.03), rs4750491 (RR m /RR p = 4.67, P interaction = 0.04), rs1090705 (RR m /RR p = 0.21, P interaction = 0.04), rs9663645 (RR m /RR p = 4.75, P interaction = 0.04), and rs200488869 (RR m /RR p = 4.75, P interaction = 0.04) from PRKCQ exhibited POE–BMI interactions.

Fisher’s exact test showed a significant overlap in the eGenes identified by either method when we considered nominally significant (p < 0.05) results, suggesting that these methods each detect similar cell-type-specific signals from bulk expression data.

The cranial base width (14q21.1), intercanthal width (1p13.3) and upper facial depth associations were at least nominally significant (p < 0.05) in both datasets.

Eleven were nominally significant for ADFI ( P < 0.05) and two were significant after Bonferroni correction.

Given the known prior association with AAA, we used a nominally significant P <0.05 to declare significance.

The case-to-control correlation difference network includes nominally significant links ( p < 0.05), whenever correlation was significant in cases and/or controls ( p < 2 × 10 –5 ).

Weak evidence: nominally significant associations (p < 0.05); v.

Among 204 exploratory pairwise correlations tested, 10 were nominally significant (p < 0.05).

However, we also observed nominally significant ( p < 0.05 uncorrected) positive associations between 5-HI and the left and right frontal poles, left insula, right caudal-middle frontal, right lateral orbitofrontal, and right lingual areas in patients with schizophrenia ( p = 0.03–0.004), whereas the right lateral occipital region had a nominally negative association with 5-HI ( p = 0.05) (Supplementary Table 4 ).

This revealed one additional independent signal (rs4786811 on chromosome 16p13.3) at a significance threshold of P <10 –5 that hadbothanacceptable clusterplotand also support from a closely correlated SNP. The clusterplots for these SNPs can be found in the online supplement, as can a list of all SNPs (online Table DS2) showing nominally significant association ( P <0.05).

All 18 metabolomic associations reported in the main analysis remained nominally significant after adjusting for diet quality and energy intake ( p < 0.05) (Additional file 1 : Table S3), and 10 metabolomic associations remained significant after multiple testing correction, including 1-docosahexaenoyl-GPC (22:6)*, pyridoxate, uridine and DHA metabolites later on used in the downstream epigenome-wide association analysis.

These 25 marks were tested for association with prostate cancer, and nominally significant associations (p < 0.05) with aggressive prostate cancer were found for all 9 marks near VTRNA2-1 (Table 1 ), with most remaining nominally significant after dichotomising (Supplementary Table 2), (as previously reported, based on the same datasets [ 5 ]).

Sex-specific SI Trends during Growth The interaction effect of categorical age (<6 or ≥6 years) and sex on SI was nominally significant ( p = 0.05).

We found that four SNPs showed nominally significant associations at P <0.05 for rs26232 ( C5orf30 ), rs2073838 ( SLC22A4 ), rs11676922 ( AFF3 ), and rs7528684 ( FCRL3 ).