“nominally significant”

Several associations related to what was observed in the NKCC1 patients were found to be nominally significant ( P < 0.05) in this analysis, including dyshidrosis, chronic bronchitis, and intestinal obstruction (see Table 4 ).

One hundred sixty of 282 (56.73%) of nominally significant associations ( P < 0.05) were reproduced with the original effect direction.

Tests of differences in estimated cell-type composition between trisomic and disomic organoids indicated nominally significant differences ( p < 0.05 by Welch’s t -test before multiple hypotheses correction) for three cell-types—glial progenitor cells, cortical neurons, and interneuron—but after Bonferroni-correction these were no longer statistically significant, with p ≥ 0.23 for all cell-types (see Supplementary Table 1 ).

While the vast majority of schizophrenia-associated DMPs remained at least nominally significant (n = 1003, 95.7%; p<0.05) between schizophrenia patients and controls; among those that did not, 25 (2.39%) had a significant effect associated with TRS status.

Nevertheless, in the Breslow–Day test, we detected that only two (rs72854462 and rs1438898 mapped to TEX41 gene) of the 821 tested SNPs were nominally significant ( p < 0.05), signaling heterogeneity in the odds ratios (OR) of these variants between Mexico and Colombia (see Supplementary Table 3 ).

Seventy CpGs (in 41 genes) showed nominally significant associations ( P < 0.05) with AD-ND codependence in both AAs and EAs.

In addition, two SNPs within this gene and one SNP within the nearby THRA were nominally significant (p < 0.05, Table 1 ).

To be included as a training feature in the outer loop, we required that a given functional connection exhibit at least one nominally significant behavioral correlation ( p < .05) across all folds of the inner loop.

5 ; p < 5 × 10 −8 ) were also at least nominally significant in the other niche ( p < 0.05), consistent with our and previous findings that tongue dorsum and salivary microbiome communities exhibited high levels of similarity 45 , 46 , especially in the micron-scale structure of oral niches 36 , 47 .

Nominally significant association ( P <0.05) was found with 18 SNPs, in three main clusters across three adjacent genes SLCO3A1 , ST8SIA2 , and C15orf32 ( Table 1 ).

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

None of these were nominally significant in the full UKBB dataset ( p -value > 0.05).

At a nominally significant level ( p < 0.05), 319 DEGs were found (164 genes expressed at higher levels in LS; 155 lower) (Additional file 5 : Table S2).

Furthermore, when applying a sequential analysis approach in an N-of-1 framework, we were able to determine that 13 of the 15 individuals with nominally significant systolic blood pressure changes, and 14 of the 18 individuals with diastolic blood pressure changes over six months demonstrated this trend (p < 0.05) by the fifth month of their study enrollment.

Among the 38 genes in the TRAIL pathway, seven genes achieved nominally significant association with hip OF ( p <0.05); the TNFSF10 ( TRAIL ) gene obtained the most significant p value ( p = 1.70×10 −4 ).

In subsequent analyses stratified by genotype, we observed nominally significant associations in both homozygous major and homozygous minor allele carriers ( p < 0.05).

Given this is a conservative threshold, if no proteins pass this threshold in all participants (APOE+ and APOE–), nominally significant proteins ( p < 0.05) will be considered for MR analysis based on an assessment of their association strength (e.g., how close to Bonferroni threshold) and consistency (e.g., association across subgroups).

Larger magnitude nominally significant (p<0.05) genetic correlations were also found with depression-related phenotypes (range of r g 0.46–0.52), self-reported osteoarthritis ( r g = 0.63), and ICD-10-defined osteoarthritis ( r g = 0.49) phenotypes.

Parsing the proteins from the genome-wide significant cis-pQTL dataset by whether or not an ITIM/ITAM domain was present, and then examining whether the associated SNP is nominally significant ( p < 0.05) for AD association, found a significant overrepresentation of ITIM/ITAM encoding genes with nominal AD associations.

However, nominally significant ( p < 0.05) associations were found for 15 pairs, 14 of which involved small or very small VLDLs and CpG sites in either SREBF1 or CPT1A .

The enrichment for the nominally significant association ( p < 0.05) was evaluated by a 10,000‐permutation test.

Out of 14 shared knowns that had genome-wide significant associations in OE, 7 had nominally significant ( p < 0.05) and directionally consistent associations in MCDS.

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

Lastly, we classified the sex-mQTLs with FDR-adjusted P diff < 0.05 into one of the following three categories: (i) concordant effect: association found to be FDR-significant in one sex and nominally significant ( P < 0.05) or FDR-significant in the other sex with a consistent effect direction but different magnitude; FDR-adjusted P diff < 0.05.

Of these 20 metabolites, only five showed nominally significant univariate differences between ME/CFS cases and controls (indole-3-propionic acid, aminomalonate, ornithine, leucine, and succinic acid; all p < 0.05), while the majority—including proline and indole-3-lactate, the constituents of the top-ranked interaction term—did not reach univariate significance in isolation ( p = 0.777 and p = 0.237, respectively).