“nominally significant”

None of these were nominally significant in the full UKBB dataset ( p -value > 0.05).

Comparisons were reported as nominally significant if they were p<0.05 but failed statistical significance due to the type I error control strategy.

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

To be included as a training feature in the outer loop, we required that a given functional connection exhibit at least one nominally significant behavioral correlation ( p < .05) across all folds of the inner loop.

Larger magnitude nominally significant (p<0.05) genetic correlations were also found with depression-related phenotypes (range of r g 0.46–0.52), self-reported osteoarthritis ( r g = 0.63), and ICD-10-defined osteoarthritis ( r g = 0.49) phenotypes.

Nominally significant three-way interaction terms ( p < 0.05) were identified for s-methylcysteine, alpha-aminobutyric acid, and asparagine.

The enrichment for the nominally significant association ( p < 0.05) was evaluated by a 10,000‐permutation test.

However, nominally significant ( p < 0.05) associations were found for 15 pairs, 14 of which involved small or very small VLDLs and CpG sites in either SREBF1 or CPT1A .

In subsequent analyses stratified by genotype, we observed nominally significant associations in both homozygous major and homozygous minor allele carriers ( p < 0.05).

Lastly, we classified the sex-mQTLs with FDR-adjusted P diff < 0.05 into one of the following three categories: (i) concordant effect: association found to be FDR-significant in one sex and nominally significant ( P < 0.05) or FDR-significant in the other sex with a consistent effect direction but different magnitude; FDR-adjusted P diff < 0.05.

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

No significant group differences in BMI trajectories during the pandemic were observed (F(2,392) = 0.43; P = 0.65, η p 2 = 0.002); a nominally significant increase in BMI was observed in the participants at low risk for eating disorder (pre-PD < LD2, P < 0.05) but not in those with higher eating disorder risk ( Fig. 5(d) ).

Of these 20 metabolites, only five showed nominally significant univariate differences between ME/CFS cases and controls (indole-3-propionic acid, aminomalonate, ornithine, leucine, and succinic acid; all p < 0.05), while the majority—including proline and indole-3-lactate, the constituents of the top-ranked interaction term—did not reach univariate significance in isolation ( p = 0.777 and p = 0.237, respectively).

To reduce the multiple testing burden, candidate TFs were tested for interaction with a given gene only if their marginal association with the target probe set was nominally significant ( p <0.05).

Four SNPs were nominally significant (p ≤ 0.05) in Cohort 1 and all replicated (p < 0.05) in Cohort 2.

All associations were performed in non-diabetic individuals and were statistically nominally significant at a level of P < 0.05 and adjusted for age, sex and ln BMI.

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

We assessed enrichment for nominally significant GxE interactions ( P < 0.05) in top vQTL and GWAS associations for BMI ( Dataset S3 and Methods ).

Overall, 11/17 (65%) associations were nominally significant at p<0.05, 9/17 (53%) at p<0.001.

Further, five additional SNPs were nominally significant ( P < 0.05).

For instance, rs10986600, significantly associated in EUR on chromosome 9, was nominally significant ( P < 0.05) with same effect direction in AFR (0.04) and AMR (0.03) and significant in the multi-ancestry meta-analysis.

Regardless of the Bonferroni correction, the term “nominally significant” refers to genes with Fisher’s exact test P values ≤ 0.05.

The nominally significant p -value was defined as 0.006 ≤ p < 0.050, indicating suggestive evidence for potential causality.

Mendelian randomization analysis For sex hormones, the MR IVW estimates for total T [-0.09 (-0.16, -0.01)] in men and bioavailable T [0.13 (0.03, 0.23)] in women were nominally significant ( p <0.05), but they did not pass the significance level of p < 0.0071 after Bonferroni correction.

Polymorphisms in IL-8, HIF1A, NR1l2, and VEGFA showed nominally significant association ( P ≤ 0.05) with PFS when compared with the wild-type genotypes.