“nominally significant”

However, the ADL scale had a nominally significant ( p ‐value <0.05) association with total cerebellar volume and cervical spinal cord CSA (Table S4 ).

As a matter of fact, only 10% of SNPs from the Candidate Set 1 had nominally significant p -values < 0.05, while 42% of SNPs from Set 2 were nominally significant at the same α.

In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant ( p < 0.05) and retained the same positive direction, suggesting persistence of associations.

Epigenome-wide association study of Frailty Index Testing 723,029 lsBINs in 50 FI discordant MZ twin pairs (Gr1) implementing paired t tests revealed overall N D = 27,485 bins that showed nominally significant associations ( P < 0.05), and of these, the top 20 association signals were ranged P = 7.01 −5 to 2.17 −6 .

While only nominally significant at p < 0.05, there was preliminary indication of differential methylation of genes involved in GTPase activity (GO ID:0090630) and cell-cell adhesion (GO ID:0098609) (See Supplementary material).

Step 5: We generate a ranked list of drug repositioning candidates and MOA categories that show enrichment of nominally significant ( p < 0.05) gene-based associations (MAGMA and S-PrediXcan) across compounds within each category.

At nominally significant levels ( p < 0.05) for both threshold levels, HVEM (herpesvirus entry mediator) on naive CD8 + T cells (MFI) was suggested as a protective factor for NT1.

As an exploratory study, we also indicated associations that are nominally significant with a P-value <0.05.

However, six (6) plasma proteins were observed to be nominally significant ( P < 0.05).

None of these were nominally significant in the full UKBB dataset ( p -value > 0.05).

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

To be included as a training feature in the outer loop, we required that a given functional connection exhibit at least one nominally significant behavioral correlation ( p < .05) across all folds of the inner loop.

Larger magnitude nominally significant (p<0.05) genetic correlations were also found with depression-related phenotypes (range of r g 0.46–0.52), self-reported osteoarthritis ( r g = 0.63), and ICD-10-defined osteoarthritis ( r g = 0.49) phenotypes.

The enrichment for the nominally significant association ( p < 0.05) was evaluated by a 10,000‐permutation test.

The results, including exploratory p ‐values ( p ‐values < 0.05 are regarded as nominally significant), were interpreted descriptively.

However, nominally significant ( p < 0.05) associations were found for 15 pairs, 14 of which involved small or very small VLDLs and CpG sites in either SREBF1 or CPT1A .

In subsequent analyses stratified by genotype, we observed nominally significant associations in both homozygous major and homozygous minor allele carriers ( p < 0.05).

Several genes that were part of this network were also nominally significant ( p < 0.05) in the PGC-AD and UKBB-AC GWAS (Fig. 1d ).

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

Of these 20 metabolites, only five showed nominally significant univariate differences between ME/CFS cases and controls (indole-3-propionic acid, aminomalonate, ornithine, leucine, and succinic acid; all p < 0.05), while the majority—including proline and indole-3-lactate, the constituents of the top-ranked interaction term—did not reach univariate significance in isolation ( p = 0.777 and p = 0.237, respectively).

Lastly, we classified the sex-mQTLs with FDR-adjusted P diff < 0.05 into one of the following three categories: (i) concordant effect: association found to be FDR-significant in one sex and nominally significant ( P < 0.05) or FDR-significant in the other sex with a consistent effect direction but different magnitude; FDR-adjusted P diff < 0.05.

To reduce the multiple testing burden, candidate TFs were tested for interaction with a given gene only if their marginal association with the target probe set was nominally significant ( p <0.05).

Overlap of 5,604 nominally significant SCZ–associated genes (MAGMA gene–wise P <.05) was observed within the top expression specificity decile of the four cell populations of the white matter implicated in the disorder.

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

Although several GO categories showed nominally significant enrichment ( P -value < 0.05), none of these categories survived FDR correction ( q > 0.05 in all cases; Table S7 ).