“nominally significant”

Of these 20 metabolites, only five showed nominally significant univariate differences between ME/CFS cases and controls (indole-3-propionic acid, aminomalonate, ornithine, leucine, and succinic acid; all p < 0.05), while the majority—including proline and indole-3-lactate, the constituents of the top-ranked interaction term—did not reach univariate significance in isolation ( p = 0.777 and p = 0.237, respectively).

To reduce the multiple testing burden, candidate TFs were tested for interaction with a given gene only if their marginal association with the target probe set was nominally significant ( p <0.05).

In subsequent analyses stratified by genotype, we observed nominally significant associations in both homozygous major and homozygous minor allele carriers ( p < 0.05).

To observe overall genetic control of gene expression in a disease context, we intersected all cis-eQTL results with the nominally significant GWAS SNPs ( p < 0.05) [ 8 ] and plotted the p values from the two sets (Fig. 2 ).

A total of four measures – all involving social and conduct problems – had connectivity fingerprints divergence scores with nominally significant elevations above 0 ( p < .05 uncorrected, Figure 2b ).

Here, we restricted the GRSs to index variants from the previous study 21 that were not only GWAS significant for at least one trait, but also nominally significant ( p -value < 0.05) for the remaining traits.

By fitting a linear mixed-effects model, we identified a total of 497 genes with nominally significant difference (p< 0.05) in viral infection response between asthmatic and non-asthmatic groups ( S6 Dataset ).

However, a nominally significant (i.e., unadjusted p < .05) group difference was found in average thalamic radiation MD bilaterally (TBI < OI).

We contrasted polygamous and monogamous evolutionary regimes at each age class and report comparisons both nominally significant ( P < 0.05) and significant after Bonferroni correction ( P < 0.01).

Regardless of the Bonferroni correction, the term “nominally significant” refers to genes with Fisher’s exact test P values ≤ 0.05.

The resulting p -values were considered nominally significant at p < 0.05 level.

These loci remained at least nominally significant (p < 0.05) in all five iterations (online Supporting Information Table S14 ).

Using TDT, we identified eight nominally significant associated SNPs ( p =<0.05).

The nominally significant p -value was defined as 0.006 ≤ p < 0.050, indicating suggestive evidence for potential causality.

In the primary MR analysis, 24 lipid metabolites showed nominally significant associations ( p < 0.05) with the risk of ER+ breast cancer ( Table S3 , Figure 2(a) ), while 23 metabolites were similarly associated with ER− breast cancer ( Table S4 , Figure 2(b) ).

Here we found that among 118 genes/transcripts with transcription start sites within 500 kb of rs7594852, there were five nominally significant ( P < 0.05) cis-eQTL associations (Supplementary Table 4 ).

To further explore these regions, we applied more relaxed criteria and detected two nominally significant eQTLs ( P < 0.05) in the NJMU lung eQTL database: MTAP at 9p21.3 and TCF7L2 at 10q25.2 (Additional file 2: Fig.

Mendelian randomization analysis For sex hormones, the MR IVW estimates for total T [-0.09 (-0.16, -0.01)] in men and bioavailable T [0.13 (0.03, 0.23)] in women were nominally significant ( p <0.05), but they did not pass the significance level of p < 0.0071 after Bonferroni correction.

BNC2 rs10756819 was not genome-wide significant but showed a consistent and nominally significant effect in all studied cohorts ( p value <0.05); this therefore replicated our previous finding from a candidate gene study (Jacobs et al. 2012 ) suggesting that BNC2 influences subtle variation in skin color.

Index SNPs in 19 of the 21 loci exhibited interactions with alcohol as evidenced by either a suggestive 1 df interaction test or a significant/suggestive joint 2 df test in conjunction with a nominally significant ( p < 0.05) 1 df interaction test; two PP loci (represented by rs4953404 and rs12292796) appeared to be driven by main effects only (1 df interaction tests have p -values > 0.3 as shown in Table 3 ) and will be excluded from further discussion (see Figures S8 – S14 for the regional association plots for all the significant and suggestive loci).

We also found evidence of enrichment of positive effects of OCAA on both risk factors (81.1%) and disease (73%), with 43.3% and 22.3% being nominally significant (one sided p<0.05), respectively.

Instrumental Variable Analysis We identified at least nominally significant ( p <0.05) causal estimates for the effect of BMI (IV estimators) on ever and incident heart failure, ever hypertension, ever and incident T2D, ever dyslipidemia, and ever metabolic syndrome ( Table 2 ).

Additional post hoc analyses show that these SNVs remain suggestively significant ( p < 5 × 10 −5 ) when not covarying for APOE and the HRs remain in the same direction and nominally significant ( p < 0.05) when using models that include APOE ε2 and ε4 separately in dominant and additive models (Table S4 in supporting information). 3.2.2 APOE analyses Next, in Cox proportional hazard (PH) models, carriers of ε2/ε4, ε3/ε4, ε4/ε4 had an elevated HR (Cox PH HR > 1) for earlier conversion to amyloid positivity compared to ε3/ε3 homozygotes. ε2/ε3 carriers demonstrated a lower risk ratio (Cox PH HR < 1; Table 3 ).

All discovery SNP-CpG associations ( n = 497,689) were nominally significant at baseline ( P < 0.05), and 99.5% ( n = 497,443) were nominally significant during the course of the disease ( P < 0.05).

Of the 1,965 DEGs identified in our pilot study 14 , 749 (38.18%) were at least nominally significant ( P = 0.05) in our larger sample set.