Co-stimulation with rIL-2 led to increase of the proportions of functional Tregs in progressive RA patients and controls; in MTX patients, its increase was of borderline significance compared to anti-CD3-stimulated cells.
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“of borderline significance”
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This means that while mortality among HIV-negative men rose slightly (HRR = 1.48; 95%CI: 1.07–2.05), among HIV-positive men, there was evidence of borderline significance to suggest that mortality declined (HRR = 0.72; 95%CI: 0.48–1.06).
The association was of borderline significance when treating total PCB serum concentration as a continuous variable (beta = 0.0689 [SE = 0.0360]).
For three other interactions, conventional p values were of borderline significance: TNRC9 SNP rs3803662 for age at menopause (p heterogeneity =0·02); 2q35-rs13387042 for age at menarche (p heterogeneity =0·04); and 5q-rs30099 for use of HRT (p heterogeneity =0·01).
Table 1 shows the individual HLA alleles that comprise the four supertypes that remained significant or of borderline significance after adjustment for multiple tests.
Correlates of khat use in past year By demographic characteristics, those who used in khat in the previous year were more likely to be male, Muslim and (of borderline significance) day laborers, and less likely to be married and Protestant (Table 3 ).
In our patient population, PCT showed better discrimination than CRP for bacterial infection, albeit the difference was of borderline significance because of the small sample size.
In addition, very recent meta-analysis, paradoxically, showed a significant increase in the risk of myocardial infarction and an increase in cardiovascular death of borderline significance with rosiglitazone, a member of PPAR γ agonists that is widely used as antidiabetic agent [ 49 ].
Differences in the expression of SCARB1 gene across trimesters were of borderline significance, with the highest value in the 2 nd trimester.
Our data broadly confirm this pattern of reduced live birth and increased miscarriage, but refine it by showing that the excess risk is largely concentrated in women with direct sonographic markers: when adenomyosis is defined simply as “any MUSA feature”, the effect on live birth is modest and of borderline significance, whereas focusing on direct markers alone reveals a nearly 60% reduction in the odds of live birth and an almost four-fold increase in miscarriages.
Although we observed no difference in risk estimates for the association between solvent exposure and ALL risk, our analyses have shown that association between paint exposure and ALL risk was statistically significant for cases with chromosomal structural changes in leukemic cells (OR = 1.96; 95% CI, 1.24–3.10) but of borderline significance for those with numerical changes (OR = 1.48; 95% CI, 0.99–2.21).
If not otherwise specified, p values < 0.05 were considered statistically significant, while p values between 0.06 and 0.1 were considered of borderline significance.
Increasing maternal pre-pregnant BMI showed a suggestive association with lower iron stores, of borderline significance, whereas other maternal factors not associated with iron biomarkers in cord samples (Supplementary Table S5 ).
Age was positively associated with autoimmune (aOR 1.01, 95% CI 1.00–1.01; p < 0.01), bacterial (aOR 1.01, 95% CI 1.01–1.02; p < 0.001), and parasitic disease (aOR 0.98, 95% CI 0.97–0.99; p < 0.001), and inversely associated with inflammatory disease (aOR 0.98, 95% CI 0.97–0.98; p < 0.001); associations with allergic and viral disease were small (aORs approximately 1.01) and of borderline significance.
Covariates of viral hepatitis Among HIV-negative MSM, factors associated with ever having HBV infection in multivariable analysis are shown in Table 3 ; age was of borderline significance in relation to HBV infection, while the number of lifetime partners and HBV vaccination remained significantly associated with HBV status.
However, this is not consistent with the absence of a difference in ΔBMI between these 2 groups in the low-stress stratum, where the difference in energy intake was of borderline significance and nearly the same as that observed in the high-stress stratum.
Although there was a trend of increasing risk of a positive score with age, it was only of borderline significance among women aged over 75 years.
As expected, a decrease in proteins involved in fission (Fis1 and Dlp1), and an increase, albeit of borderline significance, of fusion proteins were observed [10] .
Students from Government versus independent schools had a small increase in the odds of current rural practice which was of borderline significance only.
The partial rescue by wnd 3 /Df mutations in hiw ΔN mutants is only of borderline significance (it was more significant when we used higher calcium bathing solution in our first submission).
However, these associations were only of borderline significance, and so need to be interpreted with some caution.
Other studies in Mexican-Americans and Taiwanese Chinese in sample sizes of NPDR/PDR varying from 103 to 437 revealed the association of borderline significance with a few SNPs.[ 37 54 55 56 ] However, all these associations need to be replicated to draw any meaningful biological conclusion.
A PSI-BLAST search with the Thermotoga maritma ASRT ortholog (PDB: 1NC7) against NR database detected segments of putative secreted amidases from certain chloroflexi with e-values of borderline significance (e = 0.013) and then converged.
When all biomarkers were modeled together, associations for hs-TnT and hs-TnI remained of borderline significance ( Figure 3 ), and the associations for pKIM-1 and sTNFR1 were attenuated.
Associations of higher sleep scores with lower HOMA-IR (−0.06 units; 95% CI: −0.11, −0.002) and insulin (−0.21 mg/dL; 95% CI: −0.41, −0.003) were of borderline significance ( Table 2 , Model 2 and Supplemental Table 1 , Model 2).