We found FBXW11 to be significantly enriched in binding site mutations in colon adenocarcinoma (FDR < 0.1), and of borderline significance in glioblastoma multiforme (FDR = 0.104) ( Figure 4 ).
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“of borderline significance”
In the literature
Exclusion of those patients from the analysis resulted in persistent elevations of free-T4 and TSH levels in patients with EOM enlargement, although the differences in mean TSH became of borderline significance (mean free-T4 42.4 ± 1.9 versus 52.3 ± 3.9 pmol/L ( P value 0.034); mean TSH 0.021 ± 0.006 versus 0.008 ± 0.003 mIU/L ( P value 0.054)).
It seems unlikely that differences in the results observed between the two surveys could derive from actual changes in working conditions occurred during this period, given the relatively short time elapsed, but rather to chance, also considering that interactions between gender and organizational model in 2010 for other work exposures and for health conditions were mostly of borderline significance.
As anticipated, serum aldosterone was significantly elevated in both HFpEF and HFpEF + AOF groups: AOF alone led to an increase of borderline significance ( Fig. 8 A ).
Differences in the expression of SCARB1 gene across trimesters were of borderline significance, with the highest value in the 2 nd trimester.
The means of the other markers (hsCRP, sIL-6R, IL-18, ICAM-1, and OPG) were not significantly different or of borderline significance in both groups.
DBP decreased significantly in 9 of the 13 patients, 1 additional patient showing a small decrease of borderline significance, while the other 3 patients had no significant change in DBP.
Specifically, temporal trends displayed a distinct pattern: the association with all‐cause mortality was of borderline significance before adjustment, this association strengthened significantly after covariate adjustment.
The association between maternal prenatal MBzP concentrations and diagnosis of not current asthma among those with a history of the asthma-like symptoms was of borderline significance in the linear model: RR 1.17 (95% CI: 0.98, 1.41) per ln-unit increase ( Figure 3 ).
When patients were treated with IL‐19‐IL‐2 combined with dacarbazine, a median overall survival of borderline significance was seen at 419 days post‐treatment, relative to 325 days in patients treated with dacarbazine alone.
We also found exposure to SHS increased odds of e-cigarette use among traditional school students, but this correlation was of borderline significance among vocational school students.
Assessing monounsaturated fatty acid and oleic acid consumption as continuous variables, there was evidence of an inverse association, but these associations were of borderline significance (Table 3 ).
There was a significant effect of the interaction term Strain×Week, while none of the main effects, Strain or Week were significant although Strain was of borderline significance ( Table 2 ).
Additionally, because of the study design, in which the decision to perform revascularization or deferral is at the discretion of the operator, the operator may be more likely to avoid deferral of a stenosis in the LAD than in the RCA or LCx, especially when the FFR or iFR values are of borderline significance.
Two-sided P values less than 5% were considered statistically significant and P values less than 10% were considered of borderline significance.
In our study correlation analysis reveals a relationship of borderline significance between exercise limitation and mean linear intercept, RV weight, and norepinephrine concentration.
The prevalence of hypertension was higher in the non-poorest quintiles but was only of borderline significance, which is consistent with findings of other studies that cardiovascular risk factors are associated with the economic development and where the mean level of population blood pressure is not correlated, or only weakly correlated, with economic factors ( 25 ).
The study is underpowered to consider possible difference between groups of borderline significance (see mineralocorticoids receptor antagonists).
Treatment with nitroprusside and nitroglycerin were associated with a higher mortality, but this was of borderline significance and likely confounded by bias with regard to choice of agent.[ 38 ] One study by Immink et al . compared labetalol with nitroprusside in their effects on cerebral hemodynamics in the treatment of malignant hypertension.
found higher levels of mean 24 h urinary testosterone levels in a sample of 39 nights workers, but the differences were of borderline significance [ 35 ].
Other studies evaluating IL-1 RA genetic polymorphisms in psoriasis found no association (25) or a decreased frequency of IL-1RN allele 2 in patients with late onset psoriasis (age of onset > 40 y), but the finding was only of borderline significance.[ 25 26 ] Essentially, all these studies (including the present study) have demonstrated that an anti-inflammatory IL-1β genotype is more likely to be associated with psoriasis.
However, in cases of borderline significance, we also assessed the effects with males and females combined.
Conclusions In conclusion, the effect of gene variation rs41318021 in the human SLC7A1 on blood pressure was of borderline significance at the age of 35 years, and masked by environmental factors by the age of 50 years in the TAMRISK study.
The effect of HFOV on CLD in survivors at term equivalent gestational age was inconsistent across studies and the reduction was of borderline significance overall.
The lower rate of ischaemic heart disease in vegetarians was of borderline significance when adjusted for all potential mediators simultaneously (0.90, 0.81 to 1.00; supplementary table 4).