Association of intra-tumoral TILs with pCR reached borderline significance at Day14 ( p = 0.053, Fig. 2H ), while TIL dynamics between baseline and Day14 were not more informative (Supplementary Fig. 5G, H ).
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Moreover, consistent with the PRP pattern, differences in the expression levels of miR-223 and miR-320a in PPP reached borderline significance ( p = 0.053 and p = 0.055, respectively).
The CRG score ( P = 1.80E-09) and lymph node status ( P = 3.03E-06) were independent prognostic factors, while age reached borderline significance as an independent prognostic factor ( P = 0.055).
For DCM patients, there was an improvement in LVEF for both stage B ( P = 0.004) and C patients ( P < 0.001; Figure 3 C ) and a reduction in LVIDd for stage C patients ( P = 0.002), which reached borderline significance in stage B patients ( P = 0.056; Figure 3 D ).
Cases with a low KI-67 proliferation index had a higher HPV percentage than those with a high KI-67 index, but this only reached borderline significance (p = 0.056).
The improved accuracy reached borderline significance ( p = 0.057).
In the control group, when comparing the beginning to the end of this study, the decrease from 70% to 20% in “preparation of gluten-free plates before the other food preparation” reached borderline significance ( p = 0.057).
Sex, age, ASA classification were independent risk factors for DFS (HR 1.563, 95% CI 1.021–2.394, P = 0.040; HR 1.034, 95% CI 1.015–1.052, P < 0.001; HR 2.228, 95% CI 1.386–3.584, P < 0.001, respectively), and the prognostic effect of PNI on DFS reached borderline significance (HR 1.583, 95% CI 0.985–2.545, P = 0.058) (Table 3 ).
Studying the whole population, a negative association was demonstrated between the achieved percentage of expected maximum heart rate (% max HR) and mHY stage 5±2 years after motor onset (rho = –0.51, p = 0.0011), and reached borderline significance in relation to LEDD (rho = –0.29, p = 0.058).
HLA‐A*02:01 is a common allele that, in our study, was associated with increased CB ( p = 0.008) and reached borderline significance with increased median CD ( p = 0.059).
This difference was not observed in women without ovulation ( P = 0·18; d rm = 0·57), but it reached borderline significance in women with ovulation ( P = 0·06; d rm = 0·79).
However, histology and smoking status reached borderline significance with odds ratio (OR) =0.33; 95% CI: 0.10–1.12; P=0.06 and OR =0.59; 95% CI: 0.33–1.07; P=0.08, respectively.
The association still reached borderline significance in Model III (HR = 1.033, 95% CI: 0.998–1.070, P = 0.064).
The Kaplan-Meier curves (Figure 3C ) illustrate that the time to surgical intervention in these groups reached borderline significance ( P = 0.065).
The analyses of the BIS subscales showed that this differential effect was particularly attributable to motor impulsivity (i.e., acting without thinking), where the group*time interaction reached borderline significance ( p = .066, see also Table S4 in Supplement) and post hoc tests indicated a highly significant improvement in the active group ( p = .005) but no significant change in the sham group ( p = .58).
Interestingly, although assessment mode did not significantly affect the mean length of utterances in words of the Arabic-speaking children, this reached borderline significance ( p = 0.067), with a medium effect size.
The prognosis analysis in GSE39582 (see Supplementary Table 4 for baseline characteristics) revealed that the APX3330-resolution score were significantly associated with an increased risk of recurrence in the univariate Cox regression (HR = 1.148, 95% CI: 1.054–2.081, P = 0.024) but only reached borderline significance after adjusted for other clinical factors (HR = 1.388, 95% CI: 0.976–1.974, P = 0.068) (Fig. 6 C-D).
4 ), and as indicated, despite all point-estimates favoring WPM, only the VAS score for “How hungry do you feel?” for the lunch meal was significantly lower with WPM by the conventional p < 0.05, while several reached borderline significance, e.g., during breakfast (Feeling of fullness (p = 0.069) and amount you think you could eat (p = 0.056)) and lunch (satisfaction (p = 0.054), desire to eat (p = 0.084), CAC score (p = 0.054)).
QPCR showed a trend of reduced Slc46a1 transcript levels in KO compared to WT antNPCs that reached borderline significance ( P ≤ 0.07), supported by a Western blot analysis that revealed notable loss in PCFT protein expression in Tet1 KO cells (Fig. 6C,D ).
Median time to discharge after initial positivity reached borderline significance at 34 days for cases (IQR, 15–47) compared with 15 days (IQR, 8–24) for controls (95% CI, 0.97–2.49; P = .07).
The association between HPV 16 lineage A and staging reached borderline significance (p = 0.07).
However, it reached borderline significance (p = 0.07) in the Black African and Black Caribbean ethnic groups (see Supplementary Files, S8 ).
However, in univariate Cox regression analysis where the aspect of survival time is included, FSV/LVM only reached borderline significance ( P = 0.07) for predicting survival in ATTR.
The infiltration level of CD8 + lymphocytes was significantly higher in the dual therapy group than those in other 3 groups (dual therapy vs control, 12.88% ± 7.89% vs 1.36% ± 0.93%, P = .008; dual therapy vs PD-1, 12.88% ± 7.89% vs 1.90% ± 1.03%, P = .010; dual therapy vs Reparixin, 12.88% ± 7.89% vs 3.01% ± 0.87%, P = .017) ( Figure 12 J ) The infiltration of CD8 + /PD-L1 + cytotoxic lymphocytes was also higher in the dual therapy group but just reached borderline significance (dual therapy vs control, 8.43% ± 8.68% vs 0.90% ± 0.90%, P = .071; dual therapy vs PD-1, 8.43% ± 8.68% vs 1.46% ± 0.84%, P = .090; dual therapy vs Reparixin, 8.43% ± 8.68% vs 2.39% ± 1.20%, P = .133) ( Figure 11 D ).
Although the difference reached borderline significance, there was a trend towards more rapid thinning of the RNFL in the pseudophakic eye group ( P = 0.074).