“showed a trend”

While MEKiAUTO ( NCT04214418 ) showed the combination of mitogen-activated protein kinase kinase inhibitor (MEKi) cobimetinib, HCQ, and PD-L1 inhibitor Atezolizumab demonstrated limited tolerability and efficacy in patients with advanced KRAS-mutated pancreatic ductal adenocarcinoma, clinical benefit was observed in 36% of patients, while all of whom achieved stable disease as their best response; and patients with KRAS G12R mutations showed a trend toward improved overall survival (OS) compared to those with KRAS non-G12R mutations ( 77 ).

The multiple comparison of the time spent in close interaction during the social novelty phase showed a significant preference for the new unfamiliar mouse compared to the familiar one in HTZ adult females, whereas WT females showed a trend toward preference for the new unfamiliar mouse (100.1 ± 10.0 s HTZ with unfamiliar; 60.1 ± 6.6 s HTZ with familiar; 62.3 ± 5.2 s WT with unfamiliar; 41.5 ± 3.5 s WT with familiar; two‐way ANOVA, F (1.44) = 20.19, p < 0.0001 for cylinder effect, F (1.44) = 17.47, p = 0.0001 for genotype effect and F (1.44) = 2.016, p = 0.1627 for genotype × cylinder interaction; Sidak's post hoc test: WT familiar vs. unfamiliar p = 0.19, HTZ familiar vs. unfamiliar p = 0.0008, WT unfamiliar vs.

Notably, the ORs of the sarcopenia-obesity group showed a trend of “decreasing and then increasing” (4.206→2.667→3.368), suggesting that the risk of this phenotype is driven by the synergistic effect of body composition abnormalities and metabolic disorders.

Monitoring of the intestinal fungal burden via fecal pellet culturing showed a trend in decreasing fungal recovery from the antifungal-treated group ( Fig. 4B ).

17 Furthermore, because this study showed a trend toward improvement in HbA1c levels, we assume that the inhibition of NAFLD progression due to improvement in insulin resistance also contributed to the improvement, in addition to the above mechanism.

As depicted in Figure 3B and C , PCoA and NMDS analyses demonstrated significant separation between the Con and the Mod groups, while MagO group showed a trend toward convergence with the Con group.

An ad-hoc analysis of our sample showed a trend toward better balance relative to gait speed in individuals with upper limb loss when compared to those with lower limb loss, as indicated by a lower Speed/Balance Ratio.

Albeit not significant, our skin biopsy analysis showed a trend towards acutely reduced dermal innervation.

Another multicenter RCT showed a trend toward shorter resection time, such as procedures performed by non‐expert operators, suggesting that TDs may offer procedural advantages under selected conditions [ 30 ].

The delayed mobilization group showed a trend of decreasing tendon thickness over time, suggesting maturation and functional remodeling of new tissue, ultimately achieving or approaching the anatomical state of normal tendon [ 13 ].

However, as the milling position gradually approached the top of POT, both the vibration amplitude and curvature values showed a trend of gradual reduction.

Our results showed a trend of improved inhibitory control only at the post-training periods in both ICNIC group (SSRT; visual: 111.54 ± 23.09 ms, auditory: 102.23 ± 50.96 ms) and non-training control group (SSRT; visual: 101.62 ± 29.72 ms, auditory: 93.74 ± 36.90 ms) when compared within groups.

In PANC1 cells that were not treated with gemcitabine, PLAUR silencing showed a trend toward inhibiting cell migration; however, the results did not achieve statistical significance ( p = 0.07).

Although not significant, sGFAP also showed a trend towards higher baseline values in relapse patients.

Thirteen transcripts showed a trend of higher expression in high‐elevation birds.

Accordingly, control PASMCs exposed to recombinant WFDC2 showed a trend toward increased expression levels of FOXM1 , BIRC5 (also called Survivin), and IL1 β ( Supplemental Figure S3 ), all of which are critically involved in pulmonary vascular remodeling in PAH. 27 , 28 , 29 In addition, although not statistically significant, exposure of control PASMCs to the prohypertensive factors TNF-α or PDGF-BB increased expression of WFDC2 ( Supplemental Figure S3 ).

In addition, the forest plot showed a trend toward association with higher PRETEXT group (IV) and positive PRETEXT annotation factors (VPEFM).

elsdenii exposure also showed a trend toward enhanced proliferation, but the levels were lower than those observed for P. timonensis , in line with the observed clustering.

The median PRSS22 mRNA expression levels showed a trend of gradual increase across TNM stages: 0.003 (stage I), 0.006 (stage II), 0.005 (stage III), and 0.012 (stage IV) mRNA copies/18S rRNA unit.

72 Intriguingly, the subgroup of patients who had increased bone turnover at 6 mo (CTx > mean reference-range) showed a trend for greater BMD gains on treatment, and despite a second dose of zoledronic acid, lost 5% BMD at spine and alarmingly 10% of this group experienced VFs. 29 Conversely, achieving CTx below this threshold 6 mo after an initial zoledronic acid dose was a reliable indicator for subsequent BMD preservation.

1 B analysis demonstrated that SLC16A3, SLC16A4, SLC16A5, SLC16A7, SLC16A8, SLC16A9, and SLC16A12 showed a trend of high expression in HBV negativepositive HCC patient.

The non-HIV group showed a trend toward more ( n = 3) participants with SLCO1B1 c.388A>G (*1b) single nucleotide polymorphism (SNP) homozygous variant (AA genotype), as the ART group had none ( P = 0.09).

While cortical bone thickness was not affected by treatment ( P treatment = 0.2926; Figure 7D ), mice treated with CH-223191 showed a trend for increased polar moment of inertia ( P treatment = 0.0823; Figure 7E ).

845 47 While this study showed a trend towards a protective effect of HCQ against TE, it was not statistically significant.

In this cohort, SRH showed a trend towards predicting mortality or hospital care days when comparing the best ratings of health with the worst ratings; however, intermediate ratings demonstrated less discriminatory abilities.