Tibolone was associated with significantly greater improvements in sexual interest than transdermal E2/ NETA, and showed a trend towards greater improvement in sexual function 8 .
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The averaged GO semantic similarity of mouse and human genes showed a trend similar to that of the yeast genes (Figure 4C ), with the top-100 pairs exhibiting the tightest functional connections (Additional file 1 , Figure S3).
Furthermore, super-responders showed a trend for less asynchronous LV segments (1.1 ± 1.6) than average responders (2.0 ± 1.2) at follow-up.
Similar to a study that showed a trend in reduced MDA-MB-435 mammary tumor volume in response to dietary genistein [ 16 ], we report decreased tumor growth from mice on the genistein diet compared to vehicle controls.
Patients with the cutaneous limited form of the disease showed no statistical difference in CEC and EPC numbers compared to the patients with the diffuse cutaneous form, even if FACS analysis showed a trend towards an increased number of CECs and EPCs in patients with the diffuse cutaneous form (data not shown).
Heterozygous FVL mice showed a trend towards factor XIII depletion as compared with WT mice, but this was not statistically significant ( P = 0.41).
The intervention also showed a trend to reduce the birth weight-adjusted mean BMI at 4 years of age.
Xanthine also showed a trend of decreasing in CF cells, although its p value narrowly missed the 0.05 cutoff.
Preliminary studies showed a trend towards weaker response to interferon mono-therapy in the presence of occult HBV.[ 2 , 33 ] However, these were followed by several studies which differed in their views and emphasized a minimal role for occult HBV in occult contamination in response to interferon mono-therapy or its combination with ribavirin.[ 28 , 40 – 43 , 45 ] Due to the differing results obtained in various studies, and the absence of prospective controlled trials, it becomes imperative to perform such trials to clarify the role of occult HBV infection and its impact on anti-HCV treatment.
While the male Fto Δ/Δ mice remained behind throughout adulthood, the females showed a trend of catching up in weight later on ( Figure 3D ).
Overall RFS and OS also showed a trend toward better prognosis in the NPM1 mut group ( Fig. 1B ).
Glutarylcarnitine also showed a trend of increases in a dose-dependent manner at day 4, although the p values were slightly beyond the significance cutoff of 0.05.
Additionally, cytologic findings showed a trend toward improvement in the tamoxifen group.
However, insomnia showed a trend to increase after RT (Table 4 ).
Z-360 was safe, well tolerated, and showed a trend towards reduced pain in phase Ib/IIa clinical study patients with advanced pancreatic cancer when used in combination with gemcitabine and analgesics, such as opioids [ 6 ].
The SSE-supplemented group also showed a trend towards a lower malondialdehyde-modified-LDL autoantibody titer at 12 weeks from baseline.
However, when limiting analysis to individuals without previous ill-health and with adequate energy intake reports, most of the risks instead showed a trend towards protective effects.
Although no single measure was found to be sufficiently predictive to help target candidates appropriately, the 6 MWT showed a trend to significance.
Nevertheless, cancer genes tend to expand across large genomic regions [30] , and examination of eight genes likely involved in breast cancer through low-penetrance mutations– CASP8 , COX11 , ESR1 , FGFR2 , LSP1 , MAP3K1 , RAD51L1 and TOX3 [2] – [6] , [13] , [14] –showed a trend for larger genomic loci (mean ( ) genomic extension = 211 kilo bases (kb) and standard deviation (σ) = 283 kb; compared to = 66 kb and σ = 128 kb for all annotated genes in the CGEMS GWAS rank).
Low Ecstasy users revealed a trend to the faster Alpha subband, whereas high Ecstasy users showed a trend to lower Alpha subband.
59 Elderly patients treated in the pooled randomised trials showed a trend towards better adjusted outcomes (score on modified Rankin scale 0-2 v 3-6) than those who did nor receive thrombolysis (1.8, 0.73 to 4.3; n=137). 59 Previous studies have shown findings consistent with our results but on small datasets. 20 58 60 61 62 63 64 Despite these points, treatment allocation in our study was not randomised.
It is interesting to note that the SNP tested at the CCR5 locus which is associated with both T1D and CeD, also showed a trend towards association with RA.
Clinical features of Heberden's nodes and joint deformity showed a trend towards significance.
Testing BNI activity in exudates collected from plants of increasing age (21, 28, 35, 50 and 70 days; Experiment 2) showed a trend of decreasing BNI activity in older roots (Table 1 ).
scapularis saliva showed a trend to increase CD86 expression of bone-marrow derived DC stimulated with LPS, while it inhibited IL-12 and TNFα protein expression in culture supernatants [ 32 ].We did not observe changes in IL-10 or TNFα mRNA expression at R. microplus SGE concentrations tested in RAW 264.7 cells.