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“showed a trend”

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Furthermore, over the course of the maintenance phase (W10 versus W2), the Observed and Chao1 alpha-diversity indices (richness) showed a trend of decrease in both groups, while the Shannon and Inv-Simpson indices (evenness) significantly decreased in the control group (Fig. 4 F and Supplementary Table S14), but the intergroup difference was not significant.
SGRQ and ACQ‐5 scores also showed a trend for improvement with mepolizumab vs placebo in all groups (Figure S1 ; Table S4 ); the improvement from baseline with mepolizumab exceeded the minimum clinically important difference (MCID) of 4‐points for SGRQ total score and 0.5‐points for ACQ‐5 score in all groups (Table S4 ). 8 , 9 In addition, mepolizumab vs placebo reduced blood eosinophil counts from baseline by 80%‐87% and reduced eosinophil cationic protein and eosinophil‐derived neurotoxin levels in all groups (Table S6 ).
In inter-group comparison of all quartiles (I–IV), patients with higher deterioration in SGRQ score reported more often an increase of medication ( P =0.035) and more frequent hospitalizations ( P =0.036), while the need for corticosteroids ( P =0.077) and antibiotics ( P =0.394) only showed a trend.
27 Another study showed a trend toward higher complication rates with LD reconstructions compared with abdominal flaps; however, the data were underpowered and did not achieve statistical significance. 29 With considerably higher patient numbers and longer patient follow-up, we found no difference in initial complication rates between the 2 reconstructive cohorts but significantly higher rates of additional surgery in the LD with implant-based reconstructions.