Although the results of our KM survival analysis failed to achieve statistical significance, the direction of these results showed a trend for cuproptosis-C2 to be associated with a poor prognosis ( Figure S4B ).
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Furthermore, over the course of the maintenance phase (W10 versus W2), the Observed and Chao1 alpha-diversity indices (richness) showed a trend of decrease in both groups, while the Shannon and Inv-Simpson indices (evenness) significantly decreased in the control group (Fig. 4 F and Supplementary Table S14), but the intergroup difference was not significant.
The conductivity of both roots and stems showed a trend of increasing and then decreasing, with the lowest conductivity in September and a peak in January for roots.
SGRQ and ACQ‐5 scores also showed a trend for improvement with mepolizumab vs placebo in all groups (Figure S1 ; Table S4 ); the improvement from baseline with mepolizumab exceeded the minimum clinically important difference (MCID) of 4‐points for SGRQ total score and 0.5‐points for ACQ‐5 score in all groups (Table S4 ). 8 , 9 In addition, mepolizumab vs placebo reduced blood eosinophil counts from baseline by 80%‐87% and reduced eosinophil cationic protein and eosinophil‐derived neurotoxin levels in all groups (Table S6 ).
Both showed a trend of increasing first and then decreasing, and the optimum RHA content is also the same, 2%, 4%, and 6% respectively.
In inter-group comparison of all quartiles (I–IV), patients with higher deterioration in SGRQ score reported more often an increase of medication ( P =0.035) and more frequent hospitalizations ( P =0.036), while the need for corticosteroids ( P =0.077) and antibiotics ( P =0.394) only showed a trend.
To this regard, even though S100B did not reach statistical significance it showed a trend similar to NSE.
PEG-MNPs also showed a trend in that the zeta potential shifted positively as the pH value decreased.
In four trials, GLP-1 RAs were effective in reducing rates of peripheral revascularization, gangrene, and DFU compared with placebo [ 3 , 6 , 13 ]; however, the REWIND trial showed a trend toward increased rates [ 1 ].
27 Another study showed a trend toward higher complication rates with LD reconstructions compared with abdominal flaps; however, the data were underpowered and did not achieve statistical significance. 29 With considerably higher patient numbers and longer patient follow-up, we found no difference in initial complication rates between the 2 reconstructive cohorts but significantly higher rates of additional surgery in the LD with implant-based reconstructions.
Even though other adverse events did not show significant differences, the composite outcome of adverse events showed a trend towards an increased risk in patients with intensive control (BP < 120/80 mm Hg) and optimal BP control (120–129/<80 mm Hg) compared to patients with BP levels of 130–139/80–89 mm Hg. 4.2.
The AD group showed a trend towards being less accurate than the control group and was significantly slower ( t = −2.0, p = .051 and t = 3.2, p < .005, respectively). 3.1.1.1.1.
Those not yet under treatment showed a trend of a consistently low global quality of life score in the 12-month follow-up; they started with the second best scores (81.3) and they ended the follow-up with the worst scores (80.4).
CvHsp40 , CvHsc70 and CvHsp70 showed a trend of sex-specific differences of transcript abundance in the adult stage.
The directions of the correlations were opposite: a high score on the avoidant dimension correlated with a low score on the free factor, and a high score on the anxiety dimension showed a trend toward significance with a high score on the free factor.
LKB1-positive expression showed a trend toward a better prognosis.
INH-B level in all groups showed a trend similar to that of AMH ( Table 2 ).
Catechin showed a trend towards activation but did not reach significance ( p = 0.07). 4 Discussion Max Samter's1968 paper [ 3 ] on AERD noted that, in addition to aspirin, various substances produced reactions.
Overall, expression of activation and adhesion markers on LN CD4 + T cells showed a trend toward recovery following T-MSC administration in DNCB-treated mice, although these changes did not reach statistical significance ( Fig 5E ).
The donor CHIP group showed a trend toward lower incidence of 3-year cGvHD.
The subgroup analysis showed a trend towards a slightly higher overall survival during the five-year period after certification for the patients from hospitals with a basic or priority level of medical care, without significance ( p = 0.750; p = 0.638).
From 1 to 35 dpi, the level of viral shedding in infected chickens showed a trend of first increasing and then decreasing.
Notably, patients treated with HCQ showed a trend toward reduced neutrophil ROS and decreased serum levels of the NET marker (citH3), consistent with previous clinical observations ( Figure 5 c and Figure S6 ) [ 33 ].
By comparing DSB repair efficiency in the stomachs between the control and mental stress groups, we surprisingly found that mental stress significantly suppressed NHEJ efficiency by 47.4%, while HR efficiency also showed a trend of decline, although not significant, in stomachs ( Figs. 2H , 2I and S5L ).
In the absence of ROSE, FNB showed a trend toward better diagnostic adequacy, which, however, fell short of statistical significance ( p = 0.06).