In the subgroup meta-analysis by the number of participants in each trial, vitamin or antioxidant supplements showed a trend toward a decreased (but not significant) risk of major cardiovascular events (relative risk 0.97, 95% confidence interval 0.94 to 1.01; I 2 =40%) in the subgroup meta-analysis of trials with <10 000 participants, while those supplements showed an increased (but not significant) risk of the major cardiovascular events (1.02, 0.99 to 1.04; I 2 =39%) in the subgroup meta-analysis of those with ≥10 000 participants (table 4).
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Surprisingly, however, musicians showed a trend toward over-estimation of the temporal interval in both the between -group and within -group conditions.
The data showed a trend towards diminished SSAO activity in the lysates of VAP-1Δ3-co-transfected cells when compared to the control transfected cells, even though the results did not reach statistical significance ( Figure 5C ).
Indeed insertions in this exact location have been shown to activate Jdp2 expression, 34 and consistent with this, qPCR on RNA from tumours containing insertions in Jdp2 showed a trend towards having higher expression levels of Jdp2 and lower expression levels of Trp53 , relative to Trp53 +/− tumours with no insertions in Jdp2 (randomly selected from mice on this study that had not lost the Trp53 allele by mitotic recombination; Figure 3d ).
The estimated cumulative HIV-1 incidence curves in the vaccine and placebo groups illustrate VE for two genotypes (K169 and I181X) and no efficacy for the opposite residues ( Supplementary Figure S2 ) (diagnostic tests did not show significant evidence of violation of the proportional hazards assumption) – and the cumulative HIV-1 incidence curves showed a trend toward waning vaccine effect on genotype over time, analogous to the temporal effect on efficacy seen in RV144 1 , 12 .
Levels of Aβ 42 measured using conventional immunoassays showed a trend in the opposite direction as has been well described, including in the current population [ 15 , 20 ].
Patients with baseline ferritin levels <100 ng/ml showed a trend to achieve a median Hb ≥11 g/dl earlier (week 4) than those with baseline ferritin ≥100 ng/ml, who achieved Hb ≥11 g/dl by week 6 (Figure 1 C).
Most of these genes were lowly expressed in both benign and malignant meningiomas ( Table S1 ); however, five genes ( ADCY3 , GAS7 , LAG3 , LRR32 and SPON2 ) showed a trend of elevated expression (>3 fold in mean values) in malignant meningiomas.
1F ) showed a trend to be lower in CR WT mice, and this trend reached statistical significance in TgTERT mice after 12 months of CR diet compared to the corresponding cohorts under a control diet ( Fig. 1F ; p = 0.006 ) .
Patients with negative nuclear ADA3 staining or positive cytoplasmic ADA3 staining in tumors showed a trend toward shorter DMFS; however, the association was not statistically significant ( p = 0.063 and p = 0.050, respectively) (data not shown).
Three schizophrenia and one epilepsy study used MEMS, and all showed a trend towards higher adherence rates with less frequent dosing regimens.
Although not significant, fish trained at constant-velocity showed a trend towards higher survival than fish trained at either short or long intervals.
These patients also showed a trend for shorter PSA-free survival (Figure 3 ).
On the other hand, G-Red ( Figure 5D ) showed a trend of increase with the polyphenol treatments.
Glycemic control HbA 1c , fasting glucose, 2-h OGTT glucose, maximum OGTT glucose, and area under the OGTT glucose curve showed a trend to increase in the CON group, while fasting insulin significantly increased ( P < 0.05) ( Table 1 ).
Whereas non-proficient CI users benefitted from the combined AV-mode, proficient CI users only showed a trend toward better speech perception scores.
Similarly, Kaplan Meyer curve analyses revealed that patients with high miR-150 levels showed a trend towards a better ICU prognosis ( Figure 4 B).
Imipramine showed a trend toward a significant increase in TC levels after 4 weeks and a significant increase in this parameter at the eighth week.
Similarly, newly emerged females showed a trend towards lower levels of defensin expression in comparison to pupae (Figure 2 ).
In cell culture, all CPXVs grew as efficiently as the reference strain CPXV-BR and, albeit CPXV-AUS1999-867 showed a trend of slow growing phenotype, this was not significant ( Figure S1 ).
It showed a trend to an increased return of spontaneous circulation (ROSC) rate (LUCAS = 40% vs. manual = 32%) despite interruptions for rhythm analysis and a median (± SD) of 13.1 ±7.2 min to start of mechanical chest compressions from estimated time of cardiac arrest [ 16 ].
Patients receiving verum showed a trend towards lower TSS compared to placebo-treated patients (Additional file 3 : Figure S1B).
In Table 1 , we did not find significant correlations of the medical status with genotypes ( P >0.05 for all comparisons), though DN showed a trend in association with the C-allele carriers.
The study found that while both therapies showed a trend toward Efficacy, botulinum toxin resulted in a statistically significant improvement in RLP at 1 month, which was sustained over the 6-month study period.
Three studies [ 27 , 29 , 31 ] reported on the effect of a combined intervention on the incidence of caesarean section, and all showed a trend toward decreased prevalence but this was not large enough to be statistically significant.