“showed a trend”

In the LU299 model, the combination of rogaratinib (50 mg/kg) and docetaxel showed a trend towards superior tumor growth inhibition compared to treatment with docetaxel alone (Figs. 6 a –6 b ).

We demonstrated that targeted nanovehicles efficiently decreased the viability of LFs in vitro, but in vivo analyses showed a trend of accumulation into alveolar macrophages after long-term inhalatory treatment of rodents [ 8 ].

The low concentration diagnostic histograms showed a trend of rising, falling, and rising again, and the accuracy at 10 nm was peak value.

In a recent phase 2a study in 23 patients with IPF (FLORA study), GLPG1690 600 mg once daily reduced plasma LPA C18:2 levels by at least 50% over 12 weeks; in the same treatment period, FVC showed a trend for a decline in the placebo group (mean change from baseline in week 12, ‐70 mL [95%CI, ‐208 to 68]) but remained similar to or greater than baseline values in the GLPG1690 600‐mg once‐daily group (mean change from baseline in week 12, +25 mL [95%CI, ‐75 to 124]). 21 This provides support for the concept of targeting the autotaxin‐LPA axis via inhibition of autotaxin to ameliorate IPF.

Individuals with ever‐use of aspirin showed a trend toward a slightly reduced risk of developing cutaneous SCC versus nonusers, although this was not statistically significant (RR = 0.88 [95% CI 0.75–1.03]).

Results Our project showed a trend for the increased use of low-flow anaesthesia within the department.

The K-Ras ASO phenotypic impact showed a trend to improvement when compared to the unrelated control oligo but this did not achieve significance due to the scatter of the in vivo data.

Furthermore, UC-82B showed a trend of decreasing lycopene and total antioxidant capacity with increasing salt concentration, whereas no changes in these parameters were observed in the landraces under 60 mM NaCl.

The presence of ascites before surgery ( p = 0.083) and macroscopic residual tumor after surgery ( p = 0.067) showed a trend to reduced platinum-sensitivity.

In a study of Grambaite and colleagues, a non-memory measure—as inhibitory control—showed a trend in correlation with the CSF biomarkers, and they suggested that this could be an early neuropsychological marker for detecting a subtle decline in these SCD individuals [ 91 ].

In human datasets, sortilins showed a trend to be down-regulated in the HD iPSC Consortium dataset ( Figure 2 C, Supplementary Table S3 ), in the Labadorf dataset ( Supplementary Table S6 ) and in the Lin 2016 dataset ( Supplementary Table S7 ).

However, only 13 patients among the cohort received antibiotics and the results showed a trend toward a negative influence of antibiotic use.

This discrepancy might be explained by the observation that CLS curves showed a trend of increasing measurement values with an increasing time of CLS wear [ 30 ].

IGF-II and adiponectin showed a trend to decrease with time, which concurs with the assumption that IGFs and protein share common determinants or are directly associated [ 34 ].

In the univariate analysis, one radiological variable (vertical involvement of the anterior commissure) showed a significant association with LC and one radiological variable (horizontal involvement) showed a trend towards lower LC ( Table 1 ).

On the phylum level, ASD patients showed a trend of lower relative abundance of TM7 bacteria ( Figure 2 D, Figure S4 ).

Further analysis showed that high MMP8 levels in plasma correlated with tumor stage IV and showed a trend (statistically not significant) towards favorable outcomes [ 77 ]. 2.1.2.2.

The postbiotic groups showed a trend of lower mortality as compared with other treatments.

In line with this, our previous report also showed a trend of a decrease in hepatic lipogenesis mRNAs (i.e., Srebf1 , Fasn , and Dgat2 ) in female IDH2 KO mice [ 17 ].

Advanced RAI-refractory DTC in adults has also shown promising results in a recent phase II trial of vandetanib (hazard ratio 0.63) though preliminary results of a phase 3 trial merely showed a trend favoring vandetanib and were not statistically significant [ 116 ].

On the contrary, quantitative analysis of post-operative cfDNA was always feasible and showed a trend with the clinical history of the patients, supporting the use of cfDNA to monitor therapy response also in advanced HCC.

Triple mutation of NPM1, DNMT3A and IDH1/2 showed a trend towards inferior overall survival in our discovery dataset, and was significantly associated with reduced OS in a large independent validation cohort.

However uncorrected results showed a trend of higher T1‐w image intensity in AD patients in the inferior parietal lobule, angular gyrus, precuneus, and superior parietal lobule.

The OPA‐15406 1% group was superior to the vehicle group in terms of the incidence of success based on the Investigator Global Assessment score at week 4 ( P = 0.0328), which was the primary end‐point, while the OPA‐15406 0.3% group showed a trend toward improvement in the primary end‐point.

Measurements of wound size showed a trend toward accelerated wound healing with Oleogel‐S10 but this was not statistically significant.