Barely Significant
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“showed a trend”

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In the literature

coli O111:B4 serotype, a known stimulator of nitric oxide synthase (NOS) in human hepatocytes [ 27 ], significantly decreased the expression of miR-181a, whilst treatment with 100 ng/ml showed a trend towards decreased expression of miR-181a and both 10 ng/ml and 100 ng/ml non-significantly decreased miR-21 expression.
Although exploratory analysis showed a trend towards lower leptin levels after an incomplete course of steroids, this did not reach statistical significance, and it is unclear if the association could be related to an acute suppressive effect of the initial steroid dose on placental leptin transfer and/or a stimulatory effect of >24 hour steroid exposure on adipocyte leptin production.