showed a trendP = 0.097
In multivariable Cox analysis adjusting for age, NRS2002, Burn Index, and the five most significant biomarkers from univariable analysis (NK cells, TRF, CD4/CD8 ratio, NB, and PA), none of the biomarkers retained independent prognostic significance, although NK cells showed a trend toward protection (HR = 0.97, P = 0.097) ( Table 4 ).