Barely Significant
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“showed a trend”

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In the literature

Although less than 30% of the AZA patients completed the planned 12 cycles, the study showed a trend toward improvement in RFS in the patients receiving more AZA cycles. 101 Maintenance with CC-486, a novel oral AZA formulation that allows extended dosing and prolonged activity, has also been explored, although with limited data on frequency of prior therapy with HMAs. 98 Thirty patients in CR after alloSCT received CC-486 once daily for 7 or 14 days in a 28-day cycle for up to 12 cycles and among these, 9 had received AZA prior to transplant.
When the authors compared treated patients with historical controls as in our study, they showed a trend towards a treatment benefit on time to reach EDSS 6.0 (relative risk 0.77, CI 0.58 to 1.02), which is comparable with our results considering they had a much smaller treated cohort (n=868 vs 4986) with shorter follow-up time (mean 5.2 and median 5.1 years vs 8.7 and 10 in our study).
coli O111:B4 serotype, a known stimulator of nitric oxide synthase (NOS) in human hepatocytes [ 27 ], significantly decreased the expression of miR-181a, whilst treatment with 100 ng/ml showed a trend towards decreased expression of miR-181a and both 10 ng/ml and 100 ng/ml non-significantly decreased miR-21 expression.