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“showed a trend”

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In fact, we demonstrated that the thickness of SC did not change significantly at the different time points analyzed, but showed a trend toward reduction at T1 in the treatment arm, which is against the common belief the moisturizers accumulate in and causes the swelling of SC. 36 , 37 Such a reduction of SC thickness after short‐term treatment was also observed in another study with CRS. 19 This might be due to the increased exfoliation of the superficial SC produced by the mechanical action of the regular moisturizer application.
Notably, the blue module showed a specific high expression in gmsweet15 _24 h, the brown module showed a trend of upregulation after inoculation, but gmsweet15 mutant exhibited a more substantial upregulation, while the turquoise module showed a downward trend after inoculation, contrary to the brown module, and the downregulation in gmsweet15 mutant was more pronounced ( Figures 6A – C ; Supplementary Tables S11A–C ).
[1] for their comments on our study in which we compared the characteristics of the patients hospitalised at our coronavirus disease 2019 (COVID-19) referral centre in Milan, Italy, during the last three waves of COVID-19, and showed a trend towards a reduction in the number of severely ill COVID-19 patients and a progressive increase in the proportion of SARS-CoV-2 positive patients admitted for reasons other than COVID-19 (up to 40% in July 2022, when SARS-CoV-2 Omicron BA.2 and BA.5 began to spread in Italy) [2] .
However, there are controversies about the relationship between CRP and IgAV-related GI involvement 6 , 24 In our study, IgAV patients with GI involvement showed a trend towards an increase in the level of CRP compared to other groups, suggesting elevated CRP level may be related to the development of GI involved symptoms in IgAV.
The global Moran’s I index showed a trend of first increasing and then decreasing, indicating that the spatial agglomeration of the coupling coordinated development of urban and rural water poverty in northwest China first increased and then decreased, and the heterogeneity first decreased and then increased.