Barely Significant
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“showed a trend”

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Conclusions With application of best practice as known by the time of the first three waves of the pandemic, our study failed to identify a significant improvement in mortality rate when comparing the different waves of the COVID-19 pandemic, notwithstanding, the sub-analyses showed a trend in mortality reduction in the third wave.
It is noteworthy that the subgroup of patients with prematurely terminated isoflurane, and in particular those experiencing an elevated P aCO 2, had a significantly higher peak inspiratory pressure, lower lung compliance, and showed a trend towards higher ventilator minute volume in the period -24 h to -1 h prior to the implementation of the ACD when compared with the patients with continued isoflurane sedation ( Table 5 , Supplementary Table S1 ).
Statin therapy showed a trend for reducing the risk of all-cause mortality in patients with high-risk profiles, such as older ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\ge$$\end{document} ≥ 65 years old) patients, female patients, those with multiple comorbidities (such as patients with diabetes, CHF and a higher CCI value).