Barely Significant
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“showed a trend”

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A clinical trial in 2011 revealed that vitamin D supplementation could improve the disposition index and insulin secretion, associating vitamin D supplementation with improved pancreatic β-cell function in adults at high risk for type 2 diabetes, and it showed a trend toward reducing the rise in HbA1c ( 31 ).
Similarly, PTOR infants showed a trend of having a higher Z -score for birth weight (0.15 ± 1.50) than control infants (−0.21 ± 0.94), with a p -value of 0.56. 3.3 Child dental home establishment, oral health conditions, and microbial detection Forty percent of children in the PTOR group had established a dental home by the age of 1 year ( Figure 4A ).
Three significant clinical trials have been conducted in patients with stage II CRC, including the QUASAR clinical trial, which showed a 3.6% survival benefit within 2 years of surgery 27 ; the National Surgical Adjuvant Breast and Bowel Project (NSABP; studies C-01 to C-04), which compared surgery alone to chemotherapy in stage II and stage III colon cancer and found that chemotherapy decreased risk of recurrence regardless of risk status 28 ; and the phase III MOSAIC trial (Multicenter International Study of Oxaliplatin/5-FU/LV in the Adjuvant Treatment of Colon Cancer) showed a trend for better disease-free survival in patients with stage II colon cancer. 29 In a meta-analysis, 30 5-year disease-free survival was found to be 81.4% for patients with stage II colon cancer who underwent resection without adjuvant chemotherapy and 79.3% for patients receiving adjuvant chemotherapy.
179 , 180 However, a few studies found that women showed a trend toward higher levels of amyloid in post mortem neuropathological data. 181 , 182 Further, some studies suggest that higher levels of Aβ may appear during the age of menopause relative to age‐matched males, suggesting lower resistance to amyloid in women. 183 , 184 6.2 Resistance to tau By contrast, several studies showed higher levels of tau pathology in women, as evidenced by PET imaging, 185 , 186 , 187 , 188 , 189 and post mortem data 181 , 182 , 189 implying that women may have lower resistance to tau pathology.
The apoptosis level of PASMCs from yaks stably transfected with PDK1-OEcon showed a decreasing and then an increasing trend ( Figure 7 A–D,I), which was consistent with the expression trend of the anti-apoptosis indicator Bcl-2/Bax ratio ( Figure 7 K,L), and the apoptosis level of PASMCs from yaks stably transfected with PDK1-OE showed a decreasing trend ( Figure 7 E–H,J), and the expression of anti-apoptosis indicator Bcl-2/Bax ratio showed a trend of first increase and then decrease ( Figure 7 K,L); meanwhile, the expression trend of apoptosis gene Caspase3 was consistent in both ( Figure 7 M).