“trend toward significance”

However, the trend toward significance is worthy of note and where the sample size is increased might be clinically relevant.

The small, significant correlation between kasina and practice frequency may explain the trend toward significance as regular meditation practice positively influenced mental health in other research [ 5 , 50 ].

3 h–m) with significance or trend toward significance; these HSP47 gene expression changes were not observed in other tissues, including liver, heart, and pancreas tissue (Supplementary Fig. 4a –l).

Chi-squared test revealed a p -value of 0.066, which was not statistically significant though did trend toward significance.

However, our analysis suggests the necessity of vigilant, continuous monitoring and highly individualized treatment plans, particularly as there was a noticeable trend toward significance in adverse events associated with less frequent dosing during therapy.

Although there were no significant results at the a priori threshold level, the data suggest that correlations may trend toward significance with a larger patient cohort.

There was an increasing trend toward significance in the mesenchymal subtypes in LMD group, although there was no statistical significance ( P = 0.06).

The trend toward significance in family communication satisfaction suggests potential variations in the support systems and communication dynamics within families of patients on different dialysis modalities.

However, many of the differences we report are quite stark, with p values that trend toward significance.

Furthermore, the significant linear contrast in the predicted direction and trend toward significance is supportive that memory is being manipulated in a systematic way according to task instruction.

Notably, age < 55 years demonstrated a borderline association in the multivariable model (adjusted OR = 6.13, 95% CI 0.97–38.87, p = 0.054), suggesting a potential trend toward significance ( Table 3 ).

Despite the marginal trend toward significance, the frequency of RB1/BRCA2 co-deletion was even lower (~5%, 2/41) in GISTs analyzed by MLPA, indicating independent alterations of either gene in a subset of primary GISTs.

Similar to the ML, in the PCL there was a sex trend toward significance for the volume fraction of the whole microglia ( Figure S3E )) and microglial processes ( Figure S3F ), but not microglia soma ( Figure S3G ), with females having higher volume fractions than males, an effect which did not reach significance.

Significance was set at 0.05 and trend toward significance was set at 0.10.

3.4 Correlation between leptin and imprinted genes in the adipose tissue Linear correlation analysis indicated that adipose leptin expression was positively correlated with the expression of H19 , Igf2r , Plagl1 , and Kcnq1ot1 in juvenile F1 males and females; negatively correlated with the expression of Kcnq1ot1 in adult F1 males, with a negative trend toward significance for the Cdkn1c expression; and positively correlated with the expression of Plagl1 in adult F2 females, with a positive trend toward significance for the Kcnq1ot1 expression ( Figure 5 ).

The significant findings of model 1and trend toward significance in model 2 are consistent with two studies in school-age children [ 26 , 27 ].

However, this conclusion is not definitive, as there was a noticeable trend toward significance with p -values approaching 0.05.

Given the trend toward significance in the pre meal condition, and our intention to evaluate for meal related effects, we examined whether there was evidence of a differential panic rate at individual doses.

Moreover, although there were no differences between tolperisone groups and placebo in fingers to floor distance or ODI total scores, certain subcategories of the ODI did trend toward significance for the tolperisone 200 mg TID group at day 14.

Additionally, many of the data trend toward significance, suggesting that these trends might potentially reach statistical significance in a larger population.

Results with p values between 0.05 and 0.10 were interpreted as showing a “trend toward significance,” whereas p values of 0.10 or greater were considered to be nonsignificant.

As more and higher-quality trial data emerges, this difference may also trend toward significance.

Because of rifaximin's small effect size and the large number of OTUs for which we had to correct for multiple hypothesis testing, tests for the effect of study arm interacting with time trend toward significance at the OTU level did not reach a 10% FDR threshold.

Given the trend toward significance, we performed an exploratory analysis in which we dichotomized the patients who were discharged without a ventriculoperitoneal shunt into a group with a “good” COVES (defined as COVES of ≥10, 31 patients) and 15 patients with a “bad” COVES score (defined as COVES of ≤9).

Our cohort of combined DBS‐LCIG therapy revealed improvement across most domains of PDQ‐39 with trend toward significance in activities of daily living, mobility, social, and body discomfort (Fig. 1 , Table 4 ). 17 , 18 LCIG can be entertained as a potential therapeutic option for the management of refractory fluctuations in PD patients following DBS.