“trending towards significance”

For P4HA2, changes in expression levels did not reach significance, but MCF7 conditioned lung fibroblasts were trending towards significance for downregulation in P4HA2 as compared to MCF12A conditioned lung fibroblasts (Fig. 1 C).

4B ), albeit the latter correlation was only trending towards significance.

GPX2 drives shifts in TIME and impacts ICI response In three independent experiments ( figure 5 , online supplemental figure 13 ), tumors grown subcutaneously from MOC1 overexpressing GPX2 in immunocompetent C57BL/6J mice had significantly fewer overall percentage of T cells and decreased percentages of M1-macrophages, with reduced levels of CD8 +T cells significant in 2/3 experiments and trending towards significance in a third replicate experiment.

The relationship with PT (and the association with occupational therapy trending towards significance, likely reflecting the small number of claims) may indicate that patients with more severe pain require several approaches to pain management.

Associative learning ( N = 29 individuals) and reversal learning ( N = 29 individuals) were significantly repeatable, but spatial memory ( N = 30 individuals) and inhibitory control ( N = 32 individuals), although trending towards significance, were not ( table 2 ).

Baf A1 treatment across the genotypes revealed increased p62 levels in the ataxin-3 84Q cells compared to the empty vector control and trending towards significance when compared to the ataxin-3 28Q cells ( Figure 1 D).

The chosen model (Model B) revealed, after stepwise selection, two complement proteins, C3 and C4, as significantly different between the FEP and control groups, with four complement analytes (C5, TCC, C1 inhibitor and FHR125) trending towards significance and strengthening the model.

Patients with accidents of unknown speed were trending towards significance.

As the vast majority of children in Canada (80%; Golberstein et al., 2020 ) did not have a mental health problem pre-pandemic, the association of virtual school in high school, with effects trending towards significance replicated in younger grades is an important one, especially since findings appear to be driven by worsening mental health among children without a previous mental health diagnosis.

Of the 11 genes identified in that study as significantly mutated and eight trending towards significance, nine and five, respectively, were identified as harbouring somatic mutations across 13 of our 16 cell lines ( Fig. 1 D).

Further, while we did obtain interesting results within our subgroup analyses, including 10 Hz of rTMS and single-session of rTMS trending towards significance, our small sample size may have been underpowered to detect true effects, and more studies are required to ascertain the optimal stimulation parameters to treat craving in AUD.

As can be seen in Fig 4 , the lack of effect for incongruent stimuli might be due to the SM versus NSM difference in the AVI condition was trending towards significance, but remained below threshold when assessed in isolation.

We considered differences significant when P < 0.05 and trending towards significance when P was between 0.05 and 0.10.

Patients who were younger at disease onset (r = 0.38, p = 0.054) and had a higher T1-weighted lesion volume (r = −0.32, p < 0.10) had lower accuracy on the GNG task, trending towards significance.

First, as evidenced by the change in passive range of motion for shoulder flexion trending towards significance, and given the smaller effect sizes of changes observed after tenotomy, the sample size was plausibly too small to detect the difference; in any event, this cohort study should be used to power future investigations.

The placebo group had higher CAPS and MADRS scores and reported greater disability at baseline, with differences trending towards significance.

The results for the 31-35 BMI group demonstrated lower scores when compared to the ≤ 30 BMI group but this was only significant with the Oxford scores and trending towards significance with the HAAS scores.

Significance for post hoc tests was set at p < 0.0125, and p < 0.05 was considered as trending towards significance.

The original study observed nominally or trending towards significance for some variants in a Dutch validation cohort of 76 POP cases.

However, in both studies, personal political party was trending towards significance ( p Study 1 = 0.094, p Study 2 = 0.055).

All statistical tests were two-tailed with p < 0.05 considered significant and p < 0.10 as trending towards significance.

Additionally, none of the interaction terms were significant (first-time parent status interaction: p = 0.391; education interaction: p = 0.365); however, the interaction between pregnancy planning and prenatal mental healthcare utilization was trending towards significance, in that those who endorsed planned pregnancies and prenatal mental healthcare utilization had more severe depressive symptoms compared to those with unplanned pregnancies and prenatal mental health utilization (β = −2.48, 95% CI [−5.01, 0.05], p = 0.055).

Furthermore, performance of the PDxBR clinical versus PDxBR AI-grade model was not statistically different ( p = 0.076), although trending towards significance.

A caveat to these analyses is that the sample size is small, and additional rank order splits of the data were only trending towards significance, but similar to what has been seen before for large numbers of large scale changes [26] , [27] , tumors with the most numbers of changes tended to show worse survival.

Despite the fewer differentially regulated proteins in the LC dataset 17 of these had very similar fold changes in both LC and ME/CFS datasets (supplementary Table S7 ), despite only some meeting the statistical criteria for significance, with the others trending towards significance.