Barely Significant

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Interestingly, a decreasing trend of resistance was recorded for imipenem in the studied period, suggesting a reduced circulation of carbapenem-resistant Enterobacteriaceae in pet animals, even though these bacteria have been increasing rapidly worldwide [ 68 , 69 ] and are considered priority pathogens for which new antibiotics are urgently needed by the World Health Organization [ 70 ].
Although our literature analysis revealed an increasing trend in welfare-focused published studies, it also indicated that as a percentage of total articles published since 1950, a higher percentage of articles focused on marine mammal welfare feature in Welfare and Ethics as opposed to in Aquatic journals (1.2% vs. 0.04%).
As displayed in Figure 2 , a decreasing trend of leptin concentration was found in mares belonging to Group A starting from the prepartum period until the postpartum period, whereas serum UCP1 showed decreased values during the prepartum period following by a rise until the second week after parturition ( p > 0.0001).
Although the hazard of developing LR was statistically different only between tumor-free and infiltrated margins, a tendency towards significance was found also when comparing CbCM with tumor-free margins, with a three-fold increase in the risk of LR in dogs with CbCM versus tumor-free margins.