Excerpts

Furthermore, a multicenter nationwide study conducted using asymptomatic Korean adults between 2015 and 2016 showed that although there was a decreasing trend of HP seropositivity from 1998 to 2015, the HP seroprevalence was still higher than 50% of the population [ 41 ].

ALK-positive patients showed a trend toward improved median PFS when receiving bevacizumab as part of either the pemetrexed–platinum combination or maintenance therapy (9.5 versus 5.5 months without bevacizumab; p = 0.087).

When adjusted for CD4+ count and HIV load, the odds of having oral warts for those on HAART + NNRTI alone showed a non-significant association, but for those on HAART + PI there was a highly significant association, which also suggested that HAART use increased oral warts [ 8 ].

In other cell types, we also observed a positive trend between higher expression of the 18-gene signature and lower sensitivity to navitoclax, but this reached statistical significance only in lung cancer ( N = 107 cell lines) ( Figure 7 C and S6C ). 2.8.

These findings suggest that independent of socioeconomic or environmental factors, there may be significant variations in the underlying tumor biology and differential mechanisms by which endometrial cancer propagates.

All methods revealed a definite trend to rising CTC counts with advancing tumour burden.

Regarding 12-months OS rate, the RIT group shows a clear trend for a better OS.

Significant inverse association was observed between total plasma carotenoid concentrations and oxidative stress measured by urinary 8-hydroxy-2’-deoxyguanosine (8-OHdG) while only modest significance was shown for 8-iso-prostaglandin F2α (8-iso-PGF2α).

Treatment with mevalonate alone showed a trend toward further tumor growth relative to the control group; the addition of mevalonate to metformin treatment induced a significant increase in tumor growth compared to metformin treatment alone, indicating that mevalonate could reverse the tumor-suppressing effect of metformin ( Figure 4 B–D).

From our data, BRAF mutation showed a trend towards poor DFS, despite not statistically significant ( Table 2 ).

Neither blast count nor TP53 mutation remained informative for these patients; the only highly significant variable associated with OS and PFS was H19 expression.

We detected the significant induction of multiple genes in early MDS, whereas there was an apparent trend of reduced gene expression along with disease progression.

The expression of Snail and E-cadherin in the colon tumor mass also was assessed using immunohistochemistry, and the results showed a trend similar to those seen in the Western blot analysis ( Figure S4 ).

proposed a spatial immuno-oncology index based on TIL and macrophages proximity analysis to tumor buds to provide highly significant combinatorial risk model for stage II CRC patient stratification [ 31 , 32 ].

The differences between LEM-I and LEM-IV [ 85 , 86 ], LEM and Kanai model [ 87 , 88 ], and between the current models used in clinics and those under development [ 81 , 89 ] are quite significant.

In comparison to 24 h incubation, the cytotoxicity shows an increasing trend when cells were incubated with the drug for longer durations at 48 h and 72 h.

In the crude model, we observed a statistically significant or marginally significant trend in all sites of cancer.

Univariate analysis showed no differences according to gender, blood pressure status or vigorous physical activity, but subjects with tobacco use ( p = 0.076) and obesity ( p = 0.058) showed a trend to develop RCys.

The low Tid1 gene-expressing gastric cancers showed a trend of lower disease-free survival (DFS) rate than high Tid1 gene-expressing gastric cancer patients, although this difference was not statistically significant difference ( Figure 1 C).

In fact, there has been a clear trend in recent years towards an increase in the percentage of patients diagnosed with localized NSCLC, from 16.6% in 1988 to 23.6% in 2015 (SEER database) [ 3 ].

Moreover, in a systematic literature search on the co-occurrence of NETs, and adenocarcinomas in the same segment of the gastrointestinal tract, a highly significant association was found [ 79 ].

While no changes were observed for U1692 on 18S rRNA and U4975 on 28S rRNA ( Figure S6 ), an increasing trend in Ψ1445 on 18S rRNA was found in DKC1 OE cells (shown in Figure 4 C).

G3 tissue also showed a trend toward increasing MICA mRNA levels compared to G2 tissue, suggesting that other post-transcriptional mechanisms are involved in the regulation of MICA expression in G3 specimens ( Figure 1 C). 2.2.

With regard to PFS, those patients with longer GMI showed a trend toward a better median PFS when compared to those with GMI 0–1.33 (median PFS from trabectedin 10.2 months (95% CI 0.1–20.3) vs. five months (95% CI 3.1–6.9) ( p = 0.093)), as seen in Figure 4 . 3.

Correlation of expression between lncRNA and each miRNA was also calculated: a negative trend was observed for all miRNAs, except for miR-3191-3p, in 92.1 cells, and for miR-143-3p and miR-199a-5p in MEL270 cells ( Table 1 ).