Excerpts

A trend toward significance was found between high GII and CTH, an association already reported [ 49 , 52 ].

However, recent meta-analyses demonstrated a nonsignificant trend in overweight and obese children [ 58 , 63 ] ( Table 3 ).

Apart from BxPC-3 cells, tested PDAC cell lines demonstrated either a significantly higher sensitivity to protons than photons or showed a trend towards higher sensitivity to protons that resulted in reduced tumoroid growth ( Figure 1 D).

All other endpoints had a positive trend towards favoring the experimental arm, though no statistically significant differences were observed, except for the OR rate which was superior in the experimental arm, due to a proportionally larger number of patients with CR.

PFS HR for arm B was 0.65 (95% CI: 0.41–1.03), therefore not significantly worse than arm A and with a strong trend to superiority towards arm A.

2.4 months; hazard ratio 0.63; 95% CI 0.47‒0.84; p = 0.0016) and a nonsignificant trend toward improved OS (28.5 vs. 23.9 months), in spite of a 70% crossover to a trastuzumab-containing regimen on progression in the anastrozole arm.

The low Tid1 gene-expressing gastric cancers showed a trend of lower disease-free survival (DFS) rate than high Tid1 gene-expressing gastric cancer patients, although this difference was not statistically significant difference ( Figure 1 C).

In fact, there has been a clear trend in recent years towards an increase in the percentage of patients diagnosed with localized NSCLC, from 16.6% in 1988 to 23.6% in 2015 (SEER database) [ 3 ].

Moreover, in a systematic literature search on the co-occurrence of NETs, and adenocarcinomas in the same segment of the gastrointestinal tract, a highly significant association was found [ 79 ].

PC3-KLK4 tumors showed a trend towards being smaller than PC3-Vec tumors, although considerable variation was noted ( Figure S4A ).

However, although the incidence of colorectal cancer has been on a steady decline in recent decades, the proportion of early-onset CRC defined by diagnosis before 50 years old appears to be on an increasing trend in the US and Europe [ 4 , 5 ].

At 24 months, however, the increase in IPSS was only marginally significant compared to the 32.5-Gy group but not others.

The interaction test between BC subtype and BRCA status was nearly significant ( P interaction = 0.056).

This statistically significant relationship between OS and combined marker intensity provides an intriguing model for functional outcomes as this was also highly significant in our stage III study [ 10 ]. 2.3.

Patients with a highly significant increase in CD4 + , but not CD8 + , TCR diversity after 6 weeks of PD-1 inhibition were more likely to achieve a CR.

The two-sided paired, unpaired or the one-sample t -test were used for statistical analysis and a p -value ≤ 0.05 was deemed statistically significant, while a p -value < 0.01 was considered highly significant.

The authors demonstrated that in patients with cervical cancer, α-diversity had an increasing trend, and a clear separation was found between each group for β-diversity.

They did note a trend towards significance in the post-operative setting benefitting HSRT compared to SRS for 1-year local control in tumors >3 cm (HSRT: 85.7% vs.

Biomarkers who presented with significant or closely significant p -values were then tested in a second step with regards to clinical benefit.

The interaction between BC subtype, post-NAC nodal involvement and survival was highly significant (P interaction = 0.005). 3.

However, MSI demonstrated a complete absence of CD8 + and FOXP3 + T cells within a radius of 10 μm and a highly significant lower frequency of MUM1p + CD3 − B/plasma cells within a radius of <50 μm to CD34 + HSPC in control samples, while in MDS/sAML BMB, these cells were regularly detected in these localizations.

Furthermore, GSEA performed on the expression data shows a highly significant enrichment of Rb1 regulated genes that were overexpressed in tNSC3 cells in comparison to the control NSCs ( Figure S2D, Table S10 ).

Before FF treatment, an increasing trend of baseline AKT phosphorylation was observed under serum-free culture conditions in the tested cell panel.

In particular, Ca15.3 concentrations were higher in the IPF than in the non-IPF group at t3 and t4, and showed an increasing trend.

A post-hoc analysis of the data obtained from this clinical trial showed a favorable trend for patients with p53 and EGFR mutations [ 146 ].