Excerpts

These findings, although partially significant, may suggest that a clear and consistent association between UC recovery and preoperative MRI parameters is still elusive.

As shown in Supplementary Figure S1C,D , no significant differences were observed between groups in the prevalence of infections by HHV, HPV, and β-HPV, whereas low-risk individuals showed a trend toward a higher frequency of HPyV infections.

Importantly, patients who underwent surgery after CROSS showed a trend toward improved OS compared with those who did not (44.1 vs. 19.6 months), reaffirming the critical role of surgery in achieving durable outcomes in this complex disease setting.

Among lower-grade gliomas (WHO grades 2–3), IDH-mutant tumors showed a trend toward decreased fluorescence (48.6% vs. 80.0%), although this did not reach statistical significance ( p = 0.08).

As a result, only genes with highly significant and large differential changes in expression among all datasets were retained in the analysis.

Baseline PD1 + CD8 + T-cell levels also showed a favorable trend for PFS.

Specifically, patients with CRLF2 or JAK2/EPOR rearrangements showed a trend toward lower 5-year event-free and overall survival compared to patients with ABL-class alterations or other JAK-STAT pathway alterations [ 9 ].

The highly significant HR values (random-effects model HR = 5.49; fixed-effects model HR = 8.08) underscore their role as potential drivers of tumor progression ( Figure 6 E,F).

Primary Endpoint: Total Radiation Dose The primary analysis revealed highly significant differences in total radiation exposure among techniques ( Figure 4 ).

Importantly, the association between ICI treatment duration and OS and PFS only showed marginal significance in the univariate analysis.

We further stratified patients who received LRT and found that the survival advantage associated with grade 2 irLI was present in patients with and without LRT ( Supplementary Figure S5A,C ), and the difference was statistically significant in PFS for those with LRT ( Supplementary Figure S5B ) and marginally significant for those without LRT ( Supplementary Figure S5D ).

The estimated incidence of AC in the United States is approximately 6 cases per 1,000,000 individuals annually, with an increasing trend observed over the past two decades [ 3 , 4 , 5 , 6 ].

Thirdly, highly significant statistical heterogeneities were observed across the estimations.

The volcano plot summarizes effect sizes and statistical confidence, highlighting the dense cluster of highly significant, tumor-elevated genes ( Figure 1 ). 3.2.

In this dataset, the association between MTOR and CDK12 ( n = 2/13; p = 0.027) showed statistically significant co-occurrence, while the association between TP53 and CDK12 ( n = 1/10; p = 0.162) was close to significance.

Other comorbid conditions such as peripheral artery disease, high New York Heart Association (NYHA) functional class, and chronic renal and pulmonary disease are also highly significant, albeit with a lower odds ratio.

In the multivariable model, both post-CRT CEA ( p < 0.001) and post-CRT NLR ( p = 0.007) remained statistically significant, while comorbidity and AJCC stage III showed a trend toward significance ( Table 3 ). 3.3.2.

While the overall analysis showed stability in functional outcomes post-surgery across the different metastasis groups, the nearly significant p -values for changes in KPS in patients with oligometastatic and multiple metastases suggest a trend toward functional decline.

The NRI, which measures reclassification accuracy [ 25 ], also showed a trend toward improvement.

A clear trend emerges: multimodal and weakly supervised approaches, integration of peritumoral regions, and temporal modeling are showing promise across multiple clinical targets.

Baseline body weight and estimated glomerular filtration rate at cycle 1 (GFR_C1) demonstrated borderline associations with AKD ( p = 0.06 for both), implying a possible trend toward higher risk in patients with greater body mass or lower baseline kidney function reserve.

Three-year OS was 34%, 29%, and 41% in the three groups, respectively, with a nonsignificant trend towards better OS for patients with relapsed AML and a peak 3-year OS of 51% in patients transplanted with leukemic BM infiltration <20%.

As reported in the updated MACH-NC meta-analysis, age and Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) appeared as the only significant factors influencing CRT efficacy; in fact elderly patients showed a significant shorter Overall Survival (OS) ( p = 0.03) and a negative trend, although non-significant, in Event-Free Survival (EFS) ( p = 0.06) [ 14 ] if compared with younger patients (<65 years old).

No significant benefit in survival was found between smokers and non-smokers ( p = 0.916) ( Figure 2 A), although with a positive trend in non-smokers with a delta of 6 months.

However, only a subset of ADC features in our study showed a trend toward intergroup difference, none of which reached statistical significance.