Excerpts

Although the incidence of non-cardia GC has declined in many regions—attributed to reduced Helicobacter pylori prevalence, improved food preservation, and dietary changes—an increasing trend in adenocarcinomas of the gastric cardia and esophagogastric junction has been observed, particularly in high-income countries [ 4 ].

The mortality rates for TCC at all four tract sites, however, have shown an increasing trend over the same time period.

Conclusions: There is an increasing trend in pediatric cancer incidence; while white children have the highest incidence, black children and males indicated a survival disadvantage, indicative of racial and sex variability in overall pediatric cancer in the United States. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2025 Jul 11; Revised 2025 Aug 18; Accepted 2025 Aug 26; Collection date 2025 Sep. 1.

An increasing trend is identified if both the APC and the lower bound of its 95% CI are positive, while a declining trend is indicated when both the APC and the upper bound of its 95% CI are negative.

Compared with the Huh7-LR-NC control group, the Huh7-LR-Sh group showed a trend toward a significantly decreased positive rate of Ki67 and a significantly increased positive rate of Caspase-3 ( Figure 4 H).

Both groups showed comparable survival patterns, with a slight trend toward reduced survival in WNT-altered patients at later follow-up, though this was not statistically significant.

However, odds ratios were generally <1, indicating a possible trend toward lower response rates in frailer individuals, although these findings were not statistically significant ( p > 0.05).

On UVA, GTV ≥ 30 cm 3 ( p = 0.038), and PTV ≥ 150 cm 3 ( p = 0.010) were associated with an absolute drop in platelet count by ≥50,000/mm 3 within six weeks of SBRT, while prior focal liver treatment ( p = 0.097) showed a trend toward significance.

Underlying viral cirrhosis ( p = 0.033), A6 or higher pre-SBRT Child–Pugh score ( p = 0.010), and pre-SBRT platelet count <100,000/mm 3 ( p = 0.017) were significant for a rise in Child–Pugh score of 2 points or more, and the volume of liver-GTV <1000 cm 3 ( p = 0.093) approached significance.

H&E staining of tumor sections and computational image analyses of tiles containing muscle, adipose cells, and blood vessels surrounded by cancer cells showed a clear trend of increased cancer cell invasion into the mesenchyme and muscle tissue in TSK mice, although it did not achieve statistical significance ( Figure 3 e,f).

>3 cm) had a trend towards significance.

Only the variant chr22:g.29695793:A>C, proximal to CHEK2, showed a numerical trend toward HRD enrichment.

Included studies showed a trend of increased reporting since the turn of the last decade, with 77% of included studies published after 2011 ( Table 1 ).

Primary Endpoint: Total Radiation Dose The primary analysis revealed highly significant differences in total radiation exposure among techniques ( Figure 4 ).

The volcano plot summarizes effect sizes and statistical confidence, highlighting the dense cluster of highly significant, tumor-elevated genes ( Figure 1 ). 3.2.

While the overall analysis showed stability in functional outcomes post-surgery across the different metastasis groups, the nearly significant p -values for changes in KPS in patients with oligometastatic and multiple metastases suggest a trend toward functional decline.

Baseline body weight and estimated glomerular filtration rate at cycle 1 (GFR_C1) demonstrated borderline associations with AKD ( p = 0.06 for both), implying a possible trend toward higher risk in patients with greater body mass or lower baseline kidney function reserve.

Three-year OS was 34%, 29%, and 41% in the three groups, respectively, with a nonsignificant trend towards better OS for patients with relapsed AML and a peak 3-year OS of 51% in patients transplanted with leukemic BM infiltration <20%.

As shown in Figure 2 B, average intracellular ROS levels in each cell line exhibited an increasing trend with longer NIPP treatment durations, suggesting that ROS likely plays a significant role in mediating subsequent cellular responses. 3.4.

Both primary tumors and liver METs showed a trend toward a higher frequency of NETs compared with normal samples; however, these differences were not statistically significant.

Finally, a study using data from the U.S.–Canada Children’s Oncology Group (COG) showed a marginally significant association between residential exposure to parental insecticide use and the use of professional lawn/landscape services and unilateral retinoblastoma (99 cases, OR 2.8; 1.1–6.7 and OR 2.8; 1.0–8.2, respectively) [ 64 ].

However, in the recently reported TRUST trial [ 29 ], upfront surgery showed significantly improved median PFS (22.2 months) and showed a trend toward longer overall survival (OS) (54 months), compared to neoadjuvant chemotherapy, followed by interval cytoreductive surgery (19.7 months and 48.3 months, respectively.

Nevertheless, multifocality is often perceived as a useful parameter for guiding intensified TC management, particularly in light of reports indicating an increasing trend in the number of tumor foci in recent years [ 14 , 15 , 41 , 48 ]. 4.4.

Third, although patients under 60 years of age showed a trend toward higher rates of stage IV disease and distant metastasis at diagnosis, these differences did not reach statistical significance.

Since glycerol has been implicated in promoting cancer progression in murine models [ 118 ], this pathway may be significant.