Barely Significant

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Globally, an increasing trend of community-acquired infections caused by hospital-associated resistant UPEC clones has been observed, with studies suggesting that 10-30% of community isolates may now harbor resistance traits traditionally associated with hospital strains, emphasizing the need for effective infection control measures and antimicrobial stewardship programs [ 87 ].
In another observational study of postmenopausal women using HRT, oral CEE use was associated with a significantly higher risk of VTE (OR 2.08, P = .045) than E2, with a nonsignificant trend toward increased myocardial infarction and no difference in ischemic stroke risk [ 22 ].