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autonomic nervous system cardiovascular risk chronic obstruction pulmonary disease heart rate variability lung physiology pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement no pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY Introduction The Global Burden of Disease Study 2017 reported an increasing trend in the prevalence of non-communicable diseases (NCDs), including ischemic heart disease (IHD), chronic obstructive pulmonary disease (COPD), and stroke.