Excerpts

Despite the small number of patients (n=23), highly significant and consistent changes were observed, with SAA (11.6 kDa) showing the biggest decrease in expression upon the treatment.

Here, we observed significant positive correlations for CD8 MAIT among T1D subjects with a positive trend in among controls ( Figure 3C ).

Of these, we observed significant negative correlation among MAIT cell frequency and CMV IgG abundance among controls, while T1D subjects approached significance for CD8 MAIT cells, yet were relatively weakly correlated for DN MAIT cells ( Figure 4A ).

However, as anticipated, there was a highly significant correlation between IFABP and LBP ( Supplementary Figure 2B ) associated with the increase in inflammaging phenotype during the chronic phase of treated SIV infection.

Similar to Nrf2, the mRNA levels of CAT and GPx-1 α showed an increasing trend as the graded lysine levels increased up to 2.44%, and the maximum value was observed in the 2.44% lysine diet.

Gram-negative septicemic patients showed a trend towards decreased TGF-β levels, but this was also not statistically significant ( 122 ).

Interestingly, we also noticed an increasing trend of such fold changes in most strains among adults vaccinated in 2016–2017.

The link between AE and tumor regression was highly significant ( 162 ).

Figure 3F shows a highly significant result for one of the CT types, by a blue data point appearing at the top left of the volcano plot, meaning that we identified an AA-triad that is depleted in clusters associated with CeD vs. healthy controls.

Repeated-measures ANOVA yielded highly significant results regarding calcium dependence for all venoms on plasma, which was however markedly less pronounced for fibrinogen.

Repeated CSF analyses showed a trend towards normalization of initial pathological CSF findings, while relapses were more likely to be associated with increased cell counts and total protein levels.

We observed an overall trend toward decreased HLA-DR expression on CD14 + monocytes meta-clusters in sepsis as compared to HC, which is one of the hallmarks for sepsis.

Whilst bulk sequencing techniques generate detailed readouts of gene expression, they potentially miss out on small differences on a cell-per-cell basis that may be significant when taken in context of the position in which they occur.

Moreover, the group of nBP patients showed a trend towards increased IL-17-producing T cell responses against BP180, which was not statistically significant in comparison to HC.

A phase II trial that combined MoDC vaccine with docetaxel showed a trend toward improvement in disease specific survival (DSS) ( 46 ), and results of the first phase III trial, NCT NCT02111577 that combines docetaxel and DC vaccine therapy are eagerly awaited.

p < 0.05 was considered to be significant and p < 0.01 was considered to be markedly significant.

Analysis by 2-way ANOVA indicated that the interaction of sex with the strain was extremely significant ( Figure 4C ).

While tocilizumab showed efficacy for GCA ( 49 ), it showed a trend of improvement but did not meet the study endpoint for Takayasu arteritis despite improvement in acute phase reactants ( 50 ).

The absolute numbers of B cells were also significantly reduced in the spleen of Bap1 fl/fl Cre mice and showed a trend toward reduction in the lymph nodes ( Figures 1C–E ).

Ly6C hi monocytes recruited into the brains of TKO mice showed a trend of increased TNF expression whereas significantly fewer microglia were producing TNF when compared to WT mice ( Figures 6D , D’ ).

Interestingly, we found that those with a mild/moderate radiological TB had an almost significant higher PMN-MDSC proportion than those with a more severe radiological TB ( Figure 4 ), indicating that PMN-MDSC may play a beneficial role during active TB.

The same observation can be done for surface IgM expression ( Figures 7A, C and Supplementary Figures 9A, C ) (n = 18), whose levels showed a trend toward an increase in 15 patients (7 uCLL and 8 mCLL) out of 18 cases analyzed (10 uCLL and 8 mCLL).

We noticed that only four pair dots might not provide meaningful correlations, but we indeed found a negative trend between the Y111-induced killing ability (EC50 values) and the PD-L1 positive percentages ( Supplementary Table 1 ).

In contrast, mIHC-F of hPD-L1-KLN205 tumor sections showed highly significant increases in CD8+ T cells and reductions in FoxP3+ Tregs and PD-L1 expression in PDI-1-treated mice compared with vehicle-treated mice ( Figures 5D, E ).

However, there was an increasing trend for changes in immune cell proportions during anti-PD-1 treatment; this indicated that these immune cells were associated with a favorable response to PD-1 inhibition ( Figure 5B ; Wilcoxon test).