Barely Significant

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highly significantqualifiedgold
PNI+ tumors were strongly enriched in subcluster B2 ( Supplemental Table S4 ), and differences in gene set variation analysis scores for up- (ANOVA p < 2.2 × 10 −16 ) or downregulated (ANOVA p < 2.2 × 10 −16 ) genes of the PNI-related 44-gene set were highly significant between subcluster B2 and cluster A or subcluster B1 ( Figure 1 B).
Analyzing Cyclin D1, an important regulator of cell cycle progression, we did not find significant variation in the expression levels among groups ( Figure 3 d); however, a decreasing trend in both treated groups is consistent with the lower proliferation index of PNLs MB ( Figure 1 d), suggesting that repeated administrations of the DOX-carrying NPs would be able to inhibit tumor cell proliferation also during the late stage of MB development.