Excerpts

There is, however, a trend towards significance with each follow-up visit, with the upper limit of the 95% confidence interval at 24 months being only 5.9 μm thicker than the baseline measurement is, while the lower limit is 119.7 μm thinner than the baseline measurement is.

Conclusions: A clear trend towards decreasing apelin concentrations as birthweight progressively increased was identified.

Nevertheless, due to the highly significant associations observed between CVD and OD as well as between pulmonary diseases and OD, it is reasonable to assume that there are specific pathophysiological processes connecting CVD, pulmonary diseases and OD.

Two recent studies using Cerament in DFO have reported using systemic antibiotics between 4 and 6 weeks, indicating a possible trend that clinicians are now becoming more confident limiting systemic antibiotic duration with antibiotic impregnated Cerament instillation.

We have seen a decreasing trend in both wound ooze and ‘Cerament burns’ (skin erythema from leakage of Cerament) amongst our patients, which we attribute to the learning curve associated with its use.

Furthermore, the minimum SpO 2 (%) at diagnosis was significantly correlated with the PSQ scores (%), social and school results (with a positive trend), and ADHD index (with a positive trend) at follow-up but was negatively correlated with physical abilities.

There was no correlation between %EBMIL and either positive answers ( r = 0.08) or negative answers ( r = −0.14), but there was a positive and a negative trend, respectively.

On the one hand, only a few patients are affected (1–4% after kidney transplantation) [ 10 ], so the additional costs are hardly significant due to the small number of patients.

Indeed, the presence of coronary artery disease (CAD) has been identified as having a highly significant and independent predictive role in the achievement of the recommended LDL-C goals [ 33 , 34 ], which may suggest more stringent monitoring and management of LLT to achieve the recommended therapeutic goals in patients with an established CVD.

Depression is a public health problem with an increasing trend in prevalence [ 4 ].

This showed a trend toward improved effectiveness with the higher dose, but given the number of patients in this analysis, it did not meet statistical significance. 3.1.6.

A multiple linear regression analysis showed that there was a moderately significant effect between women’s age, marital status, week of pregnancy, physical activity before pregnancy, physical activity during pregnancy, attending childbirth classes, STAI (X-1), STAI (X-2), and PSS-10.

Although not statistically significant, there was an observed trend for an increased prevalence of moderate–severe gingivitis with an increasing number of toothbrushes per day.

At the eight-month follow-up, the between-group difference remained significant (mean difference of 4.59 points) on the MCS, whereas that on the CBS was borderline significant (mean change of −0.14 points).

In consistency with our hypotheses, the results showed significant between-group differences, with the family intervention showing more benefits compared with psychoeducation on our primary outcome measures, including improvement in mental-health-related QoL at the two-month and eight-month follow-ups, and on reducing caregiver burden at the two-month follow-up, and borderline significance at the eight-month follow-up.

Despite some variation in the frequency of these modalities between single years, logistic regression did not show a significant trend over time for the frequency of CT, neurological examination, SSEP, or EEG (see Table 2 ).

Recently, a phase II RCT of Filgotinib (a Jak1-inhibitor) in pSS failed to reach its primary endpoint, consisting of a composite outcome measure; however, a sub-analysis of the trial showed a trend toward clinical efficacy in patients with severe disease [ 91 ].

This may have prevented us from analyzing the data in a different way, possibly leading to other factors that may be significant in SDM in this population.

In the multivariable model 1, TyG index showed a trend for a lower probability of ENI (categorical variable, vs. lowest tertile, medium tertile OR 1.00, 95%CI 0.63–1.58, highest tertile OR 0.59, 95%CI 0.38–0.92, overall p = 0.022; continuous variable [per unit increase], OR 0.73, 95% CI 0.56–0.94, p = 0.015).

Increasing Trend of Surgically Managed Proximal Humerus Fractures An increasing trend in shoulder arthroplasty and a subsequent decrease in other operative treatments were identified.

As TG levels increased, both controlled and uncontrolled diabetic subgroups showed a decreasing trend. Furthermore, Martin–Hopkins performed slightly better than Martin–Hopkins extended for any diabetic group with TG levels over 400 mg/dL. 3.5.

A higher SUVmax in tumor lesions at baseline showed a trend with improved OS.

In the present study, we found that in comparison with the healthy control group and topical treatment group, moderate-to-severe AD patients treated with dupilumab had the shortest COVID-19-associated disease course, although p -value (0.046) from the dupilumab treatment group compared with the topical treatment group was close to the limit of significance, which may be explained by the small sample size.

In this study, we could not draw the conclusion that dupilumab treatment remarkably improves COVID-19 symptom severity score because the p -value (0.059) was borderline significant, probably, also due to the small sample size.

However, in the present study, disease progression in FVC decreased with marginal significance after rituximab treatment, while disease progression in DLco did not change after rituximab treatment.