Barely Significant

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quite significantqualifiedgold
The unexpected finding of a quite significant proportion of ME/CFS cases showing increased levels of C1q and decreased C1 inhibitor (42.8% and 8.8%, respectively) ( Supplementary Table S1 ), together with the C1q deficiency being associated with autoimmune diseases such as systemic lupus erythematosus [ 24 ], motivated our interest to hypothesize C1q as a potential biomarker for ME/CFS subtyping. 3.4.2.
Additionally, a recently published analysis of this study group stratified by the modified version of the Charlson Comorbidity Index (mCCI) shows a similar trend towards a worse outcome of patients with high mCCI under medical rhythm control, which just failed to reach statistical significance due to being underpowered [ 24 ].
In Table 2 , we reported the results of cardiac and inflammatory markers in the four groups: we did not find any significant differences (including in routine blood biochemistry, data not shown) except for IL-6, which shows a significant trend for increasing levels from group A to D ( p for trend <0.05, by Jonckheere–Terpstra test, Table 2 ).