Excerpts

For high effectiveness, the eliminated effect is very close to zero while for low effectiveness, it is positive at about 6 percentage points and close to being significant at the 5%-level.

When screening different macrolactamization sites, the ratio of isomer yields did not follow a clear trend.

The ECE generally shows a decreasing trend with increasing trajectory length, although very short trajectories of T = 10 also achieved a low ECE, likely due to a high number of trajectories predicted with very low confidences.

Eight downregulated and five upregulated proteins (pN+ vs pN0) had a highly significant differential abundance according to the status of locoregional metastasis ( q = 3.25E-03 to 4.91E-02 for nine proteins; two proteins were exclusively detected in 50% of pN0 samples: CD209 and TGFB1I1) (Fig. 4d ; Supplementary Data 2-8 ).

The correlation of PARP1 copy number with PARP1 expression approached significance, suggesting that with a larger sample set we might find an association, as has been previously observed 76 .

1H ′) showed a clear trend, with the highest rates immediately dorsal to the VF and steadily decreasing along the DV axis.

When investigating the GM volume changes across sessions, we observed a symmetrical pattern of highly significant group differences (Fig. 1 , Supplementary Table 1 ), and post hoc analyses revealed that each of these clusters reflected reductions in regional GM in the women who were pregnant between the time points (Supplementary Table 2 ).

A nonsignificant trend was seen toward lower prevalence of diabetes (0.96 [0.90, 1.01]).

In addition, when censoring deaths at 85+ years, the association of i.FCS with CMD-specific mortality became marginally significant (0.92 [0.85, 1.00]).

The presence of these traits suggests an increase in carbohydrate intake within the LN/CA periods, and fits with the data recorded by isotopic analyses, reporting a decreasing trend in animal protein intake and an increase in vegetal protein consumption from EN to LN and CA, along with an intensification of the agricultural practices in South-Italian farming communities at the end of the Neolithic period 25 , 53 .

The only other TTLL enzyme for which we found a clear trend was TTLL13 which is significantly overexpressed in the majority of tumors (Supplementary Fig. 6f ).

By comparing the relative abundance of these cell types across conditions, we found that silencing of circCsnk1g3 was associated with a decreasing trend for regulatory T cells (Treg) and exhausted CD8+ T cells; conversely, cytotoxic CD8+ T cells showed the opposite trend (Fig. 4e ).

As a result of greenhouse warming, the observed OTEC power potential in the EEZ exhibits a positive trend during 1955–2021 with a slope of 0.80 ± 0.09 TW century −1 (Fig. 1e ).

High incidence rates of EV-A71 infection were observed before 5 years of age, which showed an increasing trend before 6 months of age and then declined, but remained very high in children aged 3–5 years old (Fig. 2b ).

In arctic Siberia, time-series δ 13 C values show a decreasing trend from near +6‰ in the Maastakh and basal Khatyspyt formations, and then an oscillation between −5 and +4‰ through the overlying reaches of the interval 25 , 26 , 35 before stabilizing near 0‰ in dolostones of the lower Turkut Formation.

Although activation was highly significant on RGD-12pN surfaces, the density of activated integrin β1 molecules was greater on RGD-23pN and still greater on RGD-33pN surfaces.

E i shows a decreasing trend over 74.2% of tropical lands and 57.5% of extratropical lands, with the few increasing areas identified over the eastern U.S., Middle East and northern high latitudes.

MTAG 15 drops SNPs with extremely significant associations with any input trait, which resulted in a number of previously reported pigmentation-associated SNPs being dropped from the model.

The mean empirical backward SI showed an increasing trend over time (Supplementary Fig. 1a ), as well as the backward IP of infectee, while IP of infector referenced by infectee onset was increasing during the early phase and later became stable till the end of the study period (Supplementary Fig. 1b ).

3 ; significant and marginally significant GCF number × Community interactions in Supplementary Table 5 ).

Although the decrease in δ 2 H OH at the PETM onset is the largest observed change, both the measured δ 2 H OH and the calculated δ 2 H OH-SW show a clear trend towards more negative values in the period leading up to the PETM onset.

Marginally significant peaks on Chr 07 and 11 are related to mild pan-chromosomal LD with these three regions and disappear when multi-locus mixed models are used.

A highly significant correlation between sites of hypermethylation and increased METTL3 binding upon EIF4A3 knockdown was observed (Supplementary Fig. 5h ).

We observed a clearly significant reduction (~50%) in the transcript levels of COX1 in both KO cell lines.

33 who documented an increasing trend of SSH in the eastern Nordic Seas from 1993 to 2017, dominated by the heat content change from the inflowing AW water.