Excerpts

1h and 2c ) also have a significant trend in the average contribution of a heatwave day towards cumulative heat.

TF13 asks by what time two differently forced simulations of annual mean surface temperature differ by more than the internal variability, and quantify emergence as the time when a significant trend can be found in the difference between two simulations.

Besides, we observed a highly significant correlation and concordance between the identity of the rearranged IGHV gene sequences obtained by IgCaller and SSeq/NGS.

While there is no obvious change for V oc (~5.5 V, 269.9 V/cm 3 ) and Q sc (~1.6 nC, 78.5 nC/cm 3 ), the peak value of short-circuit current ( I sc ) reveals an increasing trend with the frequency, from ~90 nA (4.4 μA/cm 3 ) at 1 Hz to ~180 nA (8.8 μA/cm 3 ) at 4 Hz.

Antibody responses against oncogenic pathway proteins Due to the intense lymphodepleting chemotherapy administered prior to CAR T-cell infusions, we monitored the immunoglobulin (IgG) levels in this child which paradoxically showed an increasing trend during induction (Fig. 6a ).

Each test yielded a p value which allowed us to sort features from smallest (most likely to be significant) to largest (least likely).

We also performed a gene-annotation enrichment analysis using g:Profiler 17 , 18 , and found highly significant enrichments in several gene-annotations associated with the cell surface, including the terms plasma membrane and cell periphery (Fig. 1d, e ).

Since Model 1 is a submodel of Model 2, we also compared both models by using Akaike’s Information Criterion (AIC) 32 , which penalizes more complex models, resulting in a highly significant preference for Model 2 (Supplementary Note 1 ).

However, these putative elusive cancer genes did often displayed a tendency towards significance in the MutSig2CV analysis, likely reflecting a limitation of the cohort size (Supplementary Fig. 16 ).

NDVI max has been found to have a highly significant correlation with NPP in a large range of different dryland ecosystem 31 – 33 .

We also assessed whether variants within 23 genetic loci that been previously identified in other studies with marginal significance as associated with classic KS, KSHV seropositivity, KSHV viral load, antibody response or primary effusion lymphoma 21 , 23 – 25 , 34 – 36 were present in this study and had plausible signals.

We observed a decreasing trend of branching ratios for the set of standards, uraninite for U(IV), UMoO 5 for U(V) and UO 3 for U(VI), from 0.6956, 0.6887 to 0.6640 (median values from 10–13 measurements), providing a reliable reference set to resolve U valence states (Fig. 7 ; Supplementary Table 3 ).

We observed a highly significant increase in erythroid colony-forming cells (Fig. 3d ), and a corresponding decrease in myeloid colony-forming cells (Fig. 3e ).

The evolution of stacked seismic power early in the slip cycle is characterized by a decreasing trend in both Cascadia and the laboratory.

A positive trend in the Southern Annular Mode (SAM) is associated with a strengthening and poleward shift of the Southern Ocean westerly winds 39 , which is projected to persist due to continued anthropogenic forcing 40 , 41 .

Patients carrying both ELF3 and TP53 mutations had a worse overall survival that showed a trend towards significance ( p value 0.0547; Fig. 2f ) as opposed to no difference in survival in individuals with mutations in just either one of the genes (Supplementary Fig. 8d ).

Although traditionally associated with the response to osmotic stress 29 , we observed an increase in TonEBP/NFAT5 expression in skin, lungs and (borderline significant) liver in SHRSP -HS, as well as in myocardium of aged SHRSP , despite the lack of hypertonicity (Fig. 2b and Supplementary Fig. 5 ).

Tumor size, which correlates positively with MO3 (OR = 8.9, p = 0.05), appeared as marginally significant (Supplementary Fig. 2 ).

The precipitation seasonality has a negative trend, while that of evapotranspiration has weakly increased, neither of which can account for the observed robust increasing trend in the APR ocean salinity seasonality.

Our findings demonstrate a pervasive pattern of encroachment into areas that are increasingly marginal for production, but highly significant for wildlife, and suggest that such tradeoffs may be further amplified by future cropland expansion.

From the output voltages in both cycles, a clear trend can be observed in the voltage magnitudes on both electrodes.

For AD-related pathologies of amyloid plaques and Braak stage, e2 had large and highly significant protective effects contrasted with e3/e3 and e4 carriers with odds ratios of about 0.50 for e3 contrasts and 0.10 for e4 contrasts.

Subject terms: Atmospheric science, Atmospheric dynamics, Palaeoclimate Proxy reconstructions show a decreasing trend from the Middle to Late Holocene, which conflicts with model results showing an increasing trend.

2a , bottom) indeed nicely resolved a decreasing trend from melanocytic M262 cells toward mesenchymal M381 cells, implying that the more differentiated cells are relatively richer in lipids.

As the p value of BMP7 is close to significance in the multivariate model, we searched in The Gene Expression Omnibus (GEO) database for a second cohort of lung adenocarcinoma patients to have at least 100 patients.